The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
The end of AIDS: HIV infection as a chronic disease
Open accessAbstract
Antiretroviral therapy has been a spectacular success. People are now asking if the end of AIDS is possible. For those who are motivated to take therapy and who have access to lifelong treatment, AIDS-related illnesses are no longer the primary threat, but a new set of HIV-associated complications have emerged, resulting in a novel chronic disease that for many will span several decades of life. Treatment does not fully restore immune health; as a consequence, a number of inflammation-associated and/or immunodeficiency complications such as cardiovascular disease and cancer are increasing in importance. Cumulative toxicities from exposure to antiretroviral drugs for decades cause clinically-relevant metabolic disturbances and end-organ damage. There are growing concerns that the multi-morbidity associated with HIV disease may impact healthy aging and could overwhelm some health care systems, particularly those in resource-limited regions that have yet to fully develop a chronic care model. Given the problems inherent in treating and caring for a chronic disease that might persist for several decades, a global effort to identify a cure is now underway.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
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Cited by
Schnall, R., Cho, H., & Liu, J. (2018) · JMIR mHealth and uHealth · doi:10.2196/mhealth.8851 · Cited by 239
The Syndemic Illness of HIV and Trauma: Implications for a Trauma-Informed Model of Care
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Jaeger, H., Overton, E. T., Richmond, G., Rizzardini, G., Andrade-Villanueva, J. F., Mngqibisa, R., Hermida, A. O., Thalme, A., Belonosova, E., Ajana, F., et al. (2021) · The Lancet HIV · doi:10.1016/s2352-3018(21)00185-5 · Cited by 142
Frailty in People Aging With Human Immunodeficiency Virus (HIV) Infection
Brothers, T. D., Kirkland, S., Guaraldi, G., Falutz, J., Theou, O., Johnston, B. L., & Rockwood, K. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu258 · Cited by 136
Lv, L., Wang, Q., Xu, Y., Tsao, L.-C., Nakagawa, T., Guo, H., Su, L., & Xiong, Y. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.05.007 · Cited by 100
Metadata
- Authors
- Deeks, S. G., Lewin, S. R., & Havlir, D. V.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 382
- Issue
- 9903
- Pages
- 1525-1533
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2125377515
- Cited by
- 2,063
- References
- 91
- FWCI
- 127.98
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
