Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
Abstract
Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.
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After entering a controlled, chronic phase of HIV-1 infection, the main viral reservoir of intact proviral genomes is expected to reside in memory T cell subsets that persist for years.
“after entering a controlled, chronic phase of HIV-1 infection, the main viral reservoir of intact proviral genomes is expected to reside in memory T cell subsets that persist for years. 10-12”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [12]
HAART does not offer a permanent cure because interruption of therapy leads to rapid rebound of viremia from latent reservoirs.
“Moreover, although HARRT extends the lives of HIV-1 infected patients, it does not offer a permanent cure, since interruption of therapy leads to rapid rebound of viremia from latent reservoirs [3,4].”
From Newer Gene Editing Technologies toward HIV Gene Therapy (2013) · cites this paper as [4]
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Towards an HIV-1 cure: measuring the latent reservoir
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- Authors
- Siliciano, J. D., Kajdas, J., Finzi, D., Quinn, T. C., Chadwick, K., Margolick, J. B., Kovacs, C., Gange, S. J., & Siliciano, R. F.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- University of Toronto (CA)
- Corresponding author
- Siliciano, Robert F
- Venue
- Nature Medicine
- Published
- 2003-05-18
- Volume
- 9
- Issue
- 6
- Pages
- 727-728
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2101516953
- Semantic Scholar
- a37afd54ec5acffbc4e6fa57f2b2dfa1b0ad92b3
- Cited by
- 1,703
- References
- 15
- Citations by year
- 2026: 57 · 2025: 73 · 2024: 94 · 2023: 82 · 2022: 91 · 2021: 111 · 2020: 125 · 2019: 114 · 2018: 114 · 2017: 96 · 2016: 90 · 2015: 90 · 2014: 76 · 2013: 79 · 2012: 60
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Doris Duke Charitable Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI 43222, R01AI043222)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- HIV-1 latent reservoir, resting memory CD4+ T cells, highly active antiretroviral therapy, low-level viremia, HIV cure, long-term follow-up
- MeSH terms
- Follow-Up Studies, Humans, RNA, Viral, Time Factors, Viremia, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Antiretroviral Therapy, Highly Active
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