Cited by 1,703HIV Research and TreatmentHIV/AIDS drug development and treatmentInfectious Diseases and Tuberculosis

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Siliciano, Janet D, Kajdas, Joleen, Finzi, Diana, Quinn, Thomas C, Chadwick, Karen, Margolick, Joseph B, Kovacs, Colin, Gange, Stephen J +1 more·2003·Nature Medicine

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.

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Crossref · 10.1038/nm880

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  • After entering a controlled, chronic phase of HIV-1 infection, the main viral reservoir of intact proviral genomes is expected to reside in memory T cell subsets that persist for years.

    “after entering a controlled, chronic phase of HIV-1 infection, the main viral reservoir of intact proviral genomes is expected to reside in memory T cell subsets that persist for years. 10-12”
  • HAART does not offer a permanent cure because interruption of therapy leads to rapid rebound of viremia from latent reservoirs.

    “Moreover, although HARRT extends the lives of HIV-1 infected patients, it does not offer a permanent cure, since interruption of therapy leads to rapid rebound of viremia from latent reservoirs [3,4].”

    From Newer Gene Editing Technologies toward HIV Gene Therapy (2013) · cites this paper as [4]

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Authors
Siliciano, J. D., Kajdas, J., Finzi, D., Quinn, T. C., Chadwick, K., Margolick, J. B., Kovacs, C., Gange, S. J., & Siliciano, R. F.
Affiliations
  • Johns Hopkins University (US)
  • National Institutes of Health (US)
  • University of Toronto (CA)
Corresponding author
Siliciano, Robert F
Venue
Nature Medicine
Published
2003-05-18
Volume
9
Issue
6
Pages
727-728
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2101516953
Cited by
1,703
References
15
Citations by year
2026: 57 · 2025: 73 · 2024: 94 · 2023: 82 · 2022: 91 · 2021: 111 · 2020: 125 · 2019: 114 · 2018: 114 · 2017: 96 · 2016: 90 · 2015: 90 · 2014: 76 · 2013: 79 · 2012: 60
FWCI
13.40
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Doris Duke Charitable Foundation
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI 43222, R01AI043222)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords
HIV-1 latent reservoir, resting memory CD4+ T cells, highly active antiretroviral therapy, low-level viremia, HIV cure, long-term follow-up
MeSH terms
Follow-Up Studies, Humans, RNA, Viral, Time Factors, Viremia, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Antiretroviral Therapy, Highly Active

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