Frailty in People Aging With Human Immunodeficiency Virus (HIV) Infection
Open accessAbstract
The increasing life spans of people infected with human immunodeficiency virus (HIV) reflect enormous treatment successes and present new challenges related to aging. Even with suppression of viral loads and immune reconstitution, HIV-positive individuals exhibit excess vulnerability to multiple health problems that are not AIDS-defining. With the accumulation of multiple health problems, it is likely that many people aging with treated HIV infection may be identified as frail. Studies of frailty in people with HIV are currently limited but suggest that frailty might be feasible and useful as an integrative marker of multisystem vulnerability, for organizing care and for comprehensively measuring the impact of illness and treatment on overall health status. This review explains how frailty has been conceptualized and measured in the general population, critically reviews emerging data on frailty in people with HIV infection, and explores how the concept of frailty might inform HIV research and care.
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HAART does not protect patients from persistent immune activation, chronic inflammation, and excess risk of developing CVD and frailty.
“However, this therapy does not protect patients from the persistent immune activation, chronic inflammation, and excess risk of developing CVD and frailty131–135.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [134]
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Self-citation
- Authors
- Brothers, T. D., Kirkland, S., Guaraldi, G., Falutz, J., Theou, O., Johnston, B. L., & Rockwood, K.
- Affiliations
- Dalhousie University (CA)
- University of Modena and Reggio Emilia (IT)
- McGill University Health Centre (CA)
- Corresponding author
- Rockwood, K.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-06-05
- Volume
- 210
- Issue
- 8
- Pages
- 1170-1179
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2162308739
- Cited by
- 136
- References
- 49
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 15 · 2021: 7 · 2020: 14 · 2019: 23 · 2018: 16 · 2017: 15 · 2016: 18 · 2015: 9 · 2014: 2
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- Dalhousie Medical Research Foundation
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- frailty, HIV infection, aging with HIV, multimorbidity, frailty assessment, HIV care, health assessment, immune reconstitution
- MeSH terms
- Aging, Humans, Risk Factors, HIV Infections, Anti-HIV Agents, Antiretroviral Therapy, Highly Active
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