The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people
Open accessAbstract
BACKGROUND: The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared. In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease. METHODS: We used linked electronic health records from 1997 to 2010 in the CALIBER (CArdiovascular research using LInked Bespoke studies and Electronic health Records) programme to assemble a cohort of 1·25 million patients, 30 years of age or older and initially free from cardiovascular disease, a fifth of whom received blood pressure-lowering treatments. We studied the heterogeneity in the age-specific associations of clinically measured blood pressure with 12 acute and chronic cardiovascular diseases, and estimated the lifetime risks (up to 95 years of age) and cardiovascular disease-free life-years lost adjusted for other risk factors at index ages 30, 60, and 80 years. This study is registered at ClinicalTrials.gov, number NCT01164371. FINDINGS: During 5·2 years median follow-up, we recorded 83,098 initial cardiovascular disease presentations. In each age group, the lowest risk for cardiovascular disease was in people with systolic blood pressure of 90-114 mm Hg and diastolic blood pressure of 60-74 mm Hg, with no evidence of a J-shaped increased risk at lower blood pressures. The effect of high blood pressure varied by cardiovascular disease endpoint, from strongly positive to no effect. Associations with high systolic blood pressure were strongest for intracerebral haemorrhage (hazard ratio 1·44 [95% CI 1·32-1·58]), subarachnoid haemorrhage (1·43 [1·25-1·63]), and stable angina (1·41 [1·36-1·46]), and weakest for abdominal aortic aneurysm (1·08 [1·00-1·17]). Compared with diastolic blood pressure, raised systolic blood pressure had a greater effect on angina, myocardial infarction, and peripheral arterial disease, whereas raised diastolic blood pressure had a greater effect on abdominal aortic aneurysm than did raised systolic pressure. Pulse pressure associations were inverse for abdominal aortic aneurysm (HR per 10 mm Hg 0·91 [95% CI 0·86-0·98]) and strongest for peripheral arterial disease (1·23 [1·20-1·27]). People with hypertension (blood pressure ≥140/90 mm Hg or those receiving blood pressure-lowering drugs) had a lifetime risk of overall cardiovascular disease at 30 years of age of 63·3% (95% CI 62·9-63·8) compared with 46·1% (45·5-46·8) for those with normal blood pressure, and developed cardiovascular disease 5·0 years earlier (95% CI 4·8-5·2). Stable and unstable angina accounted for most (43%) of the cardiovascular disease-free years of life lost associated with hypertension from index age 30 years, whereas heart failure and stable angina accounted for the largest proportion (19% each) of years of life lost from index age 80 years. INTERPRETATION: The widely held assumptions that blood pressure has strong associations with the occurrence of all cardiovascular diseases across a wide age range, and that diastolic and systolic associations are concordant, are not supported by the findings of this high-resolution study. Despite modern treatments, the lifetime burden of hypertension is substantial. These findings emphasise the need for new blood pressure-lowering strategies, and will help to inform the design of randomised trials to assess them. FUNDING: Medical Research Council, National Institute for Health Research, and Wellcome Trust.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“High blood pressure (BP) is the single leading risk factor for cardiovascular disease worldwide,1–4”
From International Consensus on Standardized Clinic Blood Pressure Measurement – A Call to Action (2023) · cites this paper as [4]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292
2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.005 · Cited by 4,945
Law, M. R., Morris, J. K., & Wald, N. J. (2009) · BMJ · doi:10.1136/bmj.b1665 · Cited by 2,775
Heart disease and stroke statistics--2013 update: a report from the American Heart Association.
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · eScholarship (California Digital Library) · Cited by 2,601
Research works printed but not linked: 1
- Gallagher, 2011, Linkage of the General Practice Research Database (GPRD) with other data sources, Pharmacoepidemiol Drug Saf, 20, S230
Cited by
Sorted by citations
Items 401–500 of 1,000
Groenewegen, A., Milinković, I., Hoes, A. W., Mosterd, A., & Rutten, F. H. (2023) · Oxford University Press eBooks · doi:10.1093/med/9780198891628.003.0002 · Cited by 37
Pasea, L., Chung, S., Pujades‐Rodríguez, M., Shah, A. D., Alvarez‐Madrazo, S., Allan, V., Teo, J., Bean, D. M., Sofat, R., Dobson, R., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1438-y · Cited by 32
Self-citationWang, J., Yang, M., Wu, Q., Chen, J., Deng, S.-F., Chen, L., Wei, D., & Liang, F. (2021) · Chinese Medicine · doi:10.1186/s13020-020-00417-8 · Cited by 34
“Participants were enrolled if they fulfilled the following criteria: [1] aged between 45 and 75 years; [2] were diagnosed as stage 1 hypertension in the first visit, or used to be diagnosed as stage 1 hypertension in recent 1 year, but without any medication history; [3] without neurological, other cardiovascular, hep…”
BackgroundMethodWang, X., Carcel, C., Woodward, M., & Schutte, A. E. (2022) · Stroke · doi:10.1161/strokeaha.121.035852 · Cited by 37
Celastrol: The new dawn in the treatment of vascular remodeling diseases
Tan, J.-L., Yi, J., Cao, X.-Y., Wang, F., Xie, S.-L., Zhou, L., Li, Q., & Dai, A. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114177 · Cited by 31
Sanders, P., Svennberg, E., Diederichsen, S. Z., Crijns, H. J. G. M., Lambiase, P. D., Boriani, G., & Gelder, I. C. V. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae365 · Cited by 35
Birudaraju, D., Cherukuri, L., Kinninger, A., Chaganti, B. T., Shaikh, K. A., Hamal, S. A., Flores, F. R., Roy, S. K., & Budoff, M. J. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.09.011 · Cited by 32
Arslan, G., Ceyhan, Ö., & Mollaoğlu, M. (2020) · Journal of Human Hypertension · doi:10.1038/s41371-020-0371-z · Cited by 31
Shnayder, N. A., Петрова, М. М., Викторовна, М. П., Shesternya, P. A., Пожиленкова, Е. А., & Nasyrova, R. F. (2021) · Molecules · doi:10.3390/molecules26061556 · Cited by 31
“Arterial hypertension (AH) is a prevalent condition worldwide and is the key risk factor for non-fatal and fatal cardiovascular complications [1].”
BackgroundWu, S., Xu, Y., Zheng, R., Lu, J., Li, M., Chen, L., Huo, Y., Xu, M., Wang, T., Zhao, Z., et al. (2022) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2021.100350 · Cited by 31
He, L., Ma, T., Li, J., Luo, Y., Zhang, G., Cheng, X., & Bai, Y. (2022) · SLEEP · doi:10.1093/sleep/zsac141 · Cited by 33
Long-term follow-up of patients undergoing renal sympathetic denervation
Zeijen, V. J. M., Feyz, L., Panday, R. N., Veen, K. M., Versmissen, J., Kardys, I., Mieghem, N. M. V., & Daemen, J. (2022) · Clinical Research in Cardiology · doi:10.1007/s00392-022-02056-5 · Cited by 31
Night Shift Work, Genetic Risk, and Hypertension
Xiao, Z., Xu, C. Y., Liu, Q., Yan, Q., Liang, J., Weng, Z., Zhang, X., Xu, J., Hang, D., & Gu, A. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.04.007 · Cited by 33
Blood pressure in heart failure management and prevention
Maeda, D., Dotare, T., Matsue, Y., TERAMOTO, K., Sunayama, T., Tromp, J., & Minamino, T. (2023) · Hypertension Research · doi:10.1038/s41440-022-01158-x · Cited by 33
Global burden of atrial fibrillation/flutter: Trends from 1990 to 2019 and projections until 2044
Ma, Q., Zhu, J., Zheng, P., Zhang, J., Xia, X., Zhao, Y., Cheng, Q., & Zhang, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24052 · Cited by 30
“It is well known that high systolic blood pressure is a major modifiable risk factor for cardiovascular morbidity and mortality across different age categories [35 – 37].”
BackgroundRobson, J. C., Kiran, A., Maskell, J., Hutchings, A., Arden, N. K., Dasgupta, B., Hamilton, W. T., Emin, A., Culliford, D. J., & Luqmani, R. A. (2016) · The Journal of Rheumatology · doi:10.3899/jrheum.151024 · Cited by 31
Hypertension Treatment Rates and Health Care Worker Density
Vedanthan, R., Ray, M., Fuster, V., & Magenheim, E. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11995 · Cited by 33
Banerjee, A., Allan, V., Denaxas, S., Shah, A. D., Kotecha, D., Lambiase, P. D., Joseph, J., Lund, L. H., & Hemingway, H. (2019) · EP Europace · doi:10.1093/europace/euz220 · Cited by 30
Self-citationPacemaker‐Based Cardiac Neuromodulation Therapy in Patients With Hypertension: A Pilot Study
Kalarus, Z. F., Merkely, B. P., Neužil, P., Grabowski, M., Mitkowski, P. P., Marinskis, G., Ērglis, A., Kaźmierczak, J., Sturmberger, T., Sokal, A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020492 · Cited by 33
“5) Subject has ejection fraction 50% 6) Subject has symptoms of heart failure, NYHA Class II or greater 7) Subject has hypertrophic cardiomyopathy, restrictive cardiomyopathy or interventricular septal thickness ≥15 mm 8) Subject is on dialysis 9) Subject has estimated Glomerular Filtration Rate…”
Associations Between Blood Pressure and Accelerated DNA Methylation Aging
Xiao, L., Zan, G., Liu, C., Xu, X., Li, L., Chen, X., Zhang, Z., & Yang, X. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.022257 · Cited by 28
Peripheral Immune Cell Composition is Altered in Women Before and After a Hypertension Diagnosis
Kresovich, J. K., Xu, Z., O’Brien, K. M., Parks, C. G., Weinberg, C. R., Sandler, D. P., & Taylor, J. A. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.20001 · Cited by 30
Aspirin for Stroke Prevention in Elderly Patients With Vascular Risk Factors
Uchiyama, S., Ishizuka, N., Shimada, K., Teramoto, T., Yamazaki, T., Oikawa, S., Sugawara, M., Ando, K., Murata, M., Yokoyama, K., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.012461 · Cited by 30
Life's essential 8 and cardiovascular diseases progression among adults in the United Kingdom
Guo, H., Wang, S., Peng, H., Wang, W., Hou, T., Li, Y., Zhang, H., Jin, J., Ma, B., Qin, Y., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156031 · Cited by 29
Marinier, K., Macouillard, P., Champvallins, M. D., Deltour, N., Poulter, N. R., & Mancia, G. (2019) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4884 · Cited by 31
“The association between BP and the occurrence of cardiovascular diseases, such as myocardial infarction, stroke, and heart failure, was also confirmed when using linked data of CPRD, HES, and mortality statistics.(8) Nevertheless, several limitations should be acknowledged.”
Lee, H., Cho, S. M. J., Park, J. H., Park, S., & Kim, H. C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111832 · Cited by 29
Shao, B., Zhang, X.-T., Vernooij, R. W. M., Lv, Q., Hou, Y.-Y., Bao, Q. D., Lao, L., Liu, J., Zhang, Y., & Guyatt, G. H. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-03098-w · Cited by 29
Husain, M. J., Haider, M. S., Tarannum, R., Jubayer, S., Bhuiyan, M. R., Kostova, D., Moran, A. E., & Choudhury, S. R. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-061467 · Cited by 29
Martín‐Fernández, J., Alonso‐Safont, T., Polentinos-Castro, E., Esteban-Vasallo, M. D., Ariza-Cardiel, G., Anglada, M. I. G., Perruca, L. S., Rodríguez-Martínez, G., del Campo, R. R., & Bilbao‐González, A. (2023) · BMC Family Practice · doi:10.1186/s12875-023-02036-2 · Cited by 29
Tay, S. Y., Chang, P.-Y., Lao, W. T., Lin, Y., Chung, Y.-H., & Chan, W. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-17655-w · Cited by 29
Wellman, R. J., Sylvestre, M., Nader, P. A., Chioléro, A., Mésidor, M., Dugas, E. N., Tougri, G., & O’Loughlin, J. L. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13806 · Cited by 33
Usual blood pressure, atrial fibrillation and vascular risk: evidence from 4.3 million adults
Emdin, C. A., Anderson, S. G., Salimi-Khorshidi, G., Woodward, M., MacMahon, S., Dwyer, T., & Rahimi, K. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw053 · Cited by 73
“We used the Clinical Practice Research Datalink (CPRD), a primary care database previously validated for epidemiological research.(9,10) CPRD has been demonstrated to be nationally representative of the UK population in terms of age, sex and ethnicity;(11,12) 87% of participants in CPRD are White, 6% are South Asian,…”
MethodResultBlood Pressure Level in Late Adolescence and Risk for Cardiovascular Events
Rietz, H., Pennlert, J., Nordström, P., & Brunström, M. (2023) · Annals of Internal Medicine · doi:10.7326/m23-0112 · Cited by 28
“The association between blood pressure (BP) level and cardiovascular outcomes has been extensively studied in middle-aged and older persons (2), and some evidence exists for younger adults (3).”
BackgroundEffects of Massage on Blood Pressure in Patients With Hypertension and Prehypertension
Liao, I., Chen, S.-L., Wang, M., & Tsai, P. (2014) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000217 · Cited by 28
“Compared with participants with normal blood pressure, those with blood pressure equal to or higher than 140/90 mm Hg exhibited increased overall cardiovascular disease at 30 years of age, and they developed cardiovascular disease 5 years earlier.(22) A 7Ymm Hg reduction in SBP and 5Ymm Hg reduction in DBP are thus po…”
BackgroundKiru, G., Bicknell, C. D., Falaschetti, E., Powell, J. T., Poulter, N. R., & collaborators, O. B. O. T. A. (2016) · Health Technology Assessment · doi:10.3310/hta20590 · Cited by 28
Chen, H.-Y., & Chauhan, S. P. (2019) · International Journal of Cardiology Hypertension · doi:10.1016/j.ijchy.2019.100007 · Cited by 28
Value of plasma homocysteine to predict stroke, cardiovascular diseases, and new-onset hypertension
Feng, Y., Kang, K., Xue, Q., Chen, Y., Wang, W., & Cao, J. (2020) · Medicine · doi:10.1097/md.0000000000021541 · Cited by 28
“The CVDs included angina, myocardial infarction, percutaneous coronary intervention, and coronary artery bypass graft.([7,13,27]) For patients without hypertension at baseline (n= 597), the incidence of new-onset hypertension was collected.”
BackgroundLi, X., Jiang, L., Guo, Y., Ren, Y., Han, P., Peng, L., Shi, R., Yan, W., & Yang, Z. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01138-w · Cited by 31
Zhang, Q., Zhao, W. H., Zhao, Y., Duan, S., Liu, W., Zhang, C., Sun, S., Wang, T., Wang, X., Hung, W., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.890316 · Cited by 30
Stem cell therapy in intracerebral hemorrhage rat model
Cordeiro, M. F. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i3.618 · Cited by 28
Kangas, P., Tahvanainen, A., Tikkakoski, A., Koskela, J., Uitto, M., Viik, J., Kähönen, M. A. P., Kööbi, T., Mustonen, J. T., & Pörsti, I. H. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002883 · Cited by 28
Elevated Wall Tension Initiates Interleukin-6 Expression and Abdominal Aortic Dilation
Akerman, A. W., Stroud, R. E., Bans, R. W., Grespin, R. T., McDonald, L., LaRue, R. A., Mukherjee, R., Ikonomidis, J., Jones, J. A., & Ruddy, J. (2017) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2017.10.001 · Cited by 27
Tofano, R. J. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/26595.10456 · Cited by 27
Wu, K., Zheng, H., Wu, W., Chen, G., Cai, Z., Cai, Z., Lan, Y., Wu, D., Wu, S., & Chen, Y. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02058-1 · Cited by 27
“In the CALIBER study of electronic health records, the relative risk associated with hypertension was found to decrease with age [39].”
BackgroundResultRisk stratification of sudden cardiac death in hypertension
Tereshchenko, L., Soliman, E., Davis, B., & Oparil, S. (2017) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2017.08.012 · Cited by 22
“The lifetime risk of SCA/SCD at 30 years of age is significantly (30%) higher in individuals with HTN [12].”
BackgroundArchangelidi, O., Pujades‐Rodríguez, M., Timmis, A., Jouven, X., Denaxas, S., & Hemingway, H. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318785228 · Cited by 27
Self-citationPopa, L. E., Boca, B., Cătană, C.-S., Moldovanu, C.-G., Feier, D. S., Lebovici, A., Schiau, C., Rancea, R., Molnar, A., & Buruian, M. M. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-031799 · Cited by 28
Dietary Salt-Related Determinants of Hypertension in Rural Northern Thailand
Rusmevichientong, P., Morales, C., Castorena, G., Sapbamrer, R., Seesen, M., & Siviroj, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020377 · Cited by 34
Time‐limited diets and the gut microbiota in cardiometabolic disease
Ratiner, K., Shapiro, H., Goldenberg, K., & Elinav, E. (2022) · Journal of Diabetes · doi:10.1111/1753-0407.13288 · Cited by 27
“Hypertension refers to persistently high arterial blood pressure that, if left untreated, can lead to a number of devastating consequences such as heart failure and peripheral vascular disease.(141) Although no cure for primary hypertension is currently available, hypertension is controllable by chronic antihypertensi…”
BackgroundSuseela, R. P. B., Ambika, R. B., Mohandas, S., Menon, J. C., Numpelil, M., Vasudevan, B. K., Ved, R. R., Danaei, G., & Spiegelman, D. L. (2022) · BMJ Global Health · doi:10.1136/bmjgh-2022-010296 · Cited by 27
Packard, C. J., Weintraub, W. S., & Laufs, U. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.03.008 · Cited by 28
“The concept of lifetime risk usefully moves the focus away from short term, age-dominated risk estimation and associated treatment strategies towards lifelong goals for intervention [2,10,11].”
BackgroundWhat Should Be the Target Blood Pressure in Elderly Patients With Diabetes?
Solini, A., & Grossman, E. (2016) · Diabetes Care · doi:10.2337/dcs15-3027 · Cited by 27
Intravital imaging of the kidney in a rat model of salt-sensitive hypertension
Endres, B. T., Sandoval, R. M., Rhodes, G. J., Campos, S. B., Kamocka, M. M., McDermott-Roe, C., Staruschenko, A., Molitoris, B. A., Geurts, A. M., & Palygin, O. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00466.2016 · Cited by 27
“This is coincident with a marked increase in cardiovascular disease risk, including stroke, coronary artery disease, heart failure, atrial fibrillation, and peripheral vascular disease (3, 45).”
BackgroundNielsen, P. M., Grimm, D. G., Wehland, M., Simonsen, U., & Krüger, M. (2017) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12912 · Cited by 27
Pinto, R. D., Pietropaoli, D., & Ferri, C. (2018) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2018.04.004 · Cited by 27
Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction
Pandey, K. N. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.22072 · Cited by 28
Wacal, C., Musinguzi, S. P., Ewaju, E., Atibo, C., Alowo, D., Jorem, A., & Basalirwa, D. (2024) · Cogent Food & Agriculture · doi:10.1080/23311932.2024.2360766 · Cited by 26
“Hypertension or high blood pressure is one of the leading causes of cardiovascular diseases (rapsomaniki et al., 2014).”
Niiranen, T., Schnabel, R. B., Schutte, A. E., Biton, Y., Boriani, G., Buckley, C. M., Cameron, A. C., Damasceno, A. A. M., Diederichsen, S. Z., Doehner, W., et al. (2025) · Circulation · doi:10.1161/circulationaha.124.071047 · Cited by 29
“36 Persistent midlife hypertension is also associated with a 1.4-to 1.6-fold risk of late-life dementia.”
InfluentialNaser, A. M., UNICOMB, L. E., Doza, S., Ahmed, K. M., Rahman, M. M., Uddin, M. N., Quraishi, S. B., Selim, S., Shamsudduha, M., Burgess, W. G., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015205 · Cited by 26
Hussin, F. S., Chay, S. Y., Zarei, M., Hussin, A. S. M., Ibadullah, W. Z. W., Zaharuddin, N. D., Wazir, H., & Saari, N. (2020) · Foods · doi:10.3390/foods9121826 · Cited by 26
“Hypertension is an underlying health complication that relates directly to the prevalence of cardiovascular diseases, including heart failure, coronary artery disease, stroke, atrial fibrillation, and peripheral vascular disease [1].”
BackgroundPng, C. Y. M., Wu, J., Tang, T. Y., Png, I., Tay, J. S., & Choke, E. T. C. (2021) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2021.02.013 · Cited by 26
Yau, P. L., Kim, M., Tirsi, A., & Convit, A. J. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2014.2815 · Cited by 26
Parsons, C. E., Murad, M. H., Andersen, S., Mookadam, F., & Labonte, H. R. (2016) · Future Cardiology · doi:10.2217/fca.15.90 · Cited by 27
Age at First Childbirth and Hypertension in Postmenopausal Women
Park, S. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09182 · Cited by 26
Wilkins, J. T., Gidding, S. S., & Robinson, J. G. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000644 · Cited by 28
Cho, S. M. J., Lee, H., & Kim, H. C. (2019) · Clinical Hypertension · doi:10.1186/s40885-019-0129-5 · Cited by 26
Effect of welding fumes on the cardiovascular system: a six-year longitudinal study
Taj, T., Gliga, A. R., Hedmer, M., Wahlberg, K. E., Assarsson, E., Lundh, T., Tinnerberg, H., Albin, M. C., & Bröberg, K. (2020) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3908 · Cited by 26
“Admittedly, the differences of 5.11 and 3.12 mm Hg respectively for systolic and diastolic BP between the welders and controls in the longitudinal study are rather subtle in relation to known risks of CVD ( 10, 23 ).”
InfluentialChowdhury, M. A. B., Islam, M., Rahman, J., Uddin, M. T., Haque, M. R., & Uddin, M. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259507 · Cited by 25
Puberty Timing and Sex-Specific Trajectories of Systolic Blood Pressure: a Prospective Cohort Study
O’Neill, K., Bell, J. A., Smith, G. D., Tilling, K. M., Kearney, P. M., & O’Keeffe, L. M. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18531 · Cited by 25
Sharp, A. S. P., Cao, K. N., Esler, M., Kandzari, D. E., Lobo, M. D., Schmieder, R. E., & Pietzsch, J. B. (2024) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcae001 · Cited by 27
Hemingway, H., Feder, G. S., Fitzpatrick, N. K., Denaxas, S., Shah, A. D., & Timmis, A. (2017) · Programme Grants for Applied Research · doi:10.3310/pgfar05040 · Cited by 27
Self-citationPredictors of Undiagnosed and Uncontrolled Hypertension in the Local Community of Byblos, Lebanon
Kanj, H., Khalil, A., Kossaify, M., & Kossaify, A. (2018) · Health Services Insights · doi:10.1177/1178632918791576 · Cited by 25
Omboni, S., & Volpe, M. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0859-x · Cited by 25
“The rise in systolic blood pressure (SBP) has a greater effect on angina, myocardial infarction and peripheral artery disease, whereas increased diastolic blood pressure (DBP) is mainly associated with abdominal aortic aneurysm [3].”
BackgroundJohnson, K., Oparil, S., Davis, B. R., & Tereshchenko, L. G. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.011961 · Cited by 25
Brunt, A., Albines, D., & Hopkins-Rosseel, D. H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030294 · Cited by 27
Cortese, F., Cecere, A., Cortese, A. M., Andriani, A., Truncellito, L., Valente, F., Giordano, P., & Ciccone, M. M. (2020) · Journal of Human Hypertension · doi:10.1038/s41371-020-0307-7 · Cited by 25
Socioeconomic Status Transition Throughout Life and Risk of Dementia
Sakaniwa, R., Shirai, K., Cadar, D., Saito, T., Kondo, K., Kawachi, I. I., Steptoe, A., & Iso, H. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.12303 · Cited by 24
Omboni, S., & Volpe, M. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12471 · Cited by 24
Blood Pressure and Risk of Subarachnoid Hemorrhage in China
McGurgan, I. J., Clarke, R., Lacey, B., Kong, X. L., Chen, Z., Chen, Y., Yu, C., Bian, Z., Li, L., & Lewington, S. (2018) · Stroke · doi:10.1161/strokeaha.118.022239 · Cited by 24
Rietsema, S., Eelderink, C., Joustra, M. L., van Vliet, I. M. Y., van Londen, M., Corpeleijn, E., Singh‐Povel, C. M., Geurts, J. M. W., Kootstra‐Ros, J. E., Westerhuis, R., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz116 · Cited by 24
Satoh, M., Ohkubo, T., Asayama, K., Murakami, Y., Sugiyama, D., Waki, T., Tanaka‐Mizuno, S., Yamada, M., Saitoh, S., Sakata, K., et al. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.52613 · Cited by 24
Wagata, M., Kogure, M., Nakaya, N., Tsuchiya, N., Nakamura, T., Hirata, T., Narita, A., Metoki, H., Ishikuro, M., Kikuya, M., et al. (2020) · Hypertension Research · doi:10.1038/s41440-020-0463-8 · Cited by 24
Piko, N., Bevc, S., Hojs, R., Naji, F. H., & Ekart, R. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-01859-0 · Cited by 24
“CVD is one of the leading causes of death in Western countries, contributing to over one-third of deaths in patients aged 35 years or more [4], with men more often affected than women [5].”
BackgroundStewart, S., Chan, Y., Playford, D. A., & Strange, G. A. (2021) · European Respiratory Journal · doi:10.1183/13993003.00832-2021 · Cited by 24
“Our data is consistent with similar studies in systemic hypertension [30], in which minor elevations in systemic blood pressure have profound implications on LYL when applied across an entire cohort.”
Racial Differences in Blood Pressure Control Following Stroke: The REGARDS Study
Akinyelure, O. P., Jaeger, B. C., Moore, T. L., Hubbard, D. M., Oparil, S., Howard, V. J., Howard, G., Buie, J. N., Magwood, G. S., Adams, R. J., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.033108 · Cited by 24
Identifying peripheral arterial disease in the elderly patients using machine-learning algorithms
Gao, J.-M., Ren, Z., Pan, X., Chen, Y., Zhu, W., Li, W., Yang, Y., & Fu, G.-X. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01985-x · Cited by 24
Yoon, M., You, S. C., Oh, J., Lee, C. J., Lee, S., Kang, S., & Park, S. (2022) · Hypertension Research · doi:10.1038/s41440-021-00845-5 · Cited by 24
Tomtheelnganbee, E., Sah, P., & Sharma, R. (2022) · Biogerontology · doi:10.1007/s10522-022-09978-7 · Cited by 26
Triposkiadis, F. K., Sarafidis, P. A., Briasoulis, Α., Magouliotis, D. E., Athanasiou, T., Skoularigis, J. S., & Xanthopoulos, A. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12155090 · Cited by 27
“HTN is the most important risk factor for heart failure (HF) development, with recent evidence indicating that HTN is present in 76% of incident HF cases [4], and the lifetime risk of HF is almost twice as high in people with HTN as in those with normal blood pressure (BP) [5,6].”
BackgroundHendriks, M. E., Rosendaal, N. T. A., Wit, F. W. N. M., Bolarinwa, O. A., Kramer, B., Brals, D., Gustafsson‐Wright, E., Adenusi, P., Brewster, L. M., Osagbemi, G. K., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.09.036 · Cited by 24
Ryder, J. R., O'Connell, M., Bosch, T. A., Chow, L. S., Rudser, K. D., Dengel, D. R., Fox, C. K., Steinberger, J., & Kelly, A. S. (2015) · Pediatric Research · doi:10.1038/pr.2015.188 · Cited by 26
Zhang, Y., Jiang, X., Bo, J., Yin, L., Chen, H., Wang, Y., Yu, H., Wang, X., & Li, W. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001528 · Cited by 24
“Prospective observational studies suggest that the risk of cardiovascular disease in the general population starts to increase when blood pressure (BP) level is beyond 114/74 mmHg [12,13].”
BackgroundBoos, C. J., Hein, A., & Khattab, A. (2024) · Journal of Clinical Hypertension · doi:10.1111/jch.14755 · Cited by 23
Li, J., Liu, W., Li, H., Ye, X., & Qin, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-86385-1 · Cited by 29
Eriksson, M., Carlberg, B., Pennlert, J., Söderberg, S., & Eliasson, M. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317722263 · Cited by 25
Therapeutic Approach to Hypertension Urgencies and Emergencies During Acute Coronary Syndrome
Tocci, G., Figliuzzi, I., Presta, V., Miceli, F., Citoni, B., Coluccia, R., Musumeci, B., Ferrucci, A., & Volpe, M. (2018) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-018-0275-y · Cited by 23
Drug-induced hypertension: Know the problem to know how to deal with it
Masi, S., Uliana, M., Gesi, M., Taddei, S., & Virdis, A. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.02.002 · Cited by 27
Yan, W., Gao, Y., Zhang, Y., Guo, Y., Wang, J., Jiang, L., Li, Y., & Yang, Z. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01262-1 · Cited by 23
Shimada, T., Mascha, E. J., Yang, D., Bravo, M., Rivas, E., Ince, I., Turan, A., & Sessler, D. I. (2022) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001656 · Cited by 23
Marazzato, J., Blasi, F., Golino, M., Verdecchia, P., Angeli, F., & Ponti, R. D. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9040110 · Cited by 23
Ma, T., He, L., Luo, Y., Li, J., Zhang, G., Cheng, X., & Bai, Y. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02889-w · Cited by 23
“Participants who reported other CMDs combined with hypertension (n = 40,514) at baseline, or had missing data on the use of fish oil and covariates (n = 1222 in fish oil use, n = 19 in the dates of outcome occurrences, n = 23,511 in physical activity, and n = 2303 in other covariates) were excluded.”
ResultInfluential
Metadata
- Authors
- Rapsomaniki, E., Timmis, A., George, J., Pujades-Rodriguez, M., Shah, A. D., Denaxas, S., White, I. R., Caulfield, M. J., Deanfield, J. E., Smeeth, L., Williams, B., Hingorani, A., & Hemingway, H.
- Affiliations
- Farr Institute (GB)
- Queen Mary University of London (GB)
- MRC Biostatistics Unit (GB)
- London School of Hygiene & Tropical Medicine (GB)
- National Institute for Health and Care Research (GB)
- Corresponding author
- Rapsomaniki, Eleni
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 383
- Issue
- 9932
- Pages
- 1899-1911
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC4042017
- OpenAlex
- W2169428949
- Cited by
- 1,643
- References
- 41
- Citations by year
- 2026: 79 · 2025: 117 · 2024: 145 · 2023: 161 · 2022: 162 · 2021: 192 · 2020: 168 · 2019: 163 · 2018: 142 · 2017: 117 · 2016: 94 · 2015: 66 · 2014: 34
- FWCI
- 71.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Lancet (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health Research (NIHR) (RP-PG-0407–10314)
- Wellcome Trust (086091/Z/08/Z, 0938/30/Z/10/Z)
- Medical Research Council Prognosis Research Strategy (PROGRESS) Partnership (G0902393/99558)
- Medical Research Council, Arthritis Research UK, British Heart Foundation, Cancer Research UK, Chief Scientist Office, Economic and Social Research Council, Engineering and Physical Sciences Research Council, NIHR, National Institute for Social Care and Health Research, and Wellcome Trust (MR/K006584/1)
- NIHR Doctoral Fellowship (DRF-2009–02–50)
- Medical Research Council (U105260558)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- blood pressure, cardiovascular disease incidence, systolic blood pressure, diastolic blood pressure, pulse pressure, lifetime risk, healthy life years lost, intracerebral hemorrhage, subarachnoid hemorrhage, myocardial infarction, stable angina, peripheral arterial disease, abdominal aortic aneurysm, stroke, hypertension, age-specific associations, blood pressure-lowering treatment, J-curve
- MeSH terms
- Acute Disease, Adult, Aged, Aged, 80 and over, Angina Pectoris, Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Chronic Disease, England, Female, Follow-Up Studies, Humans, Hypertension, Male, Medical Record Linkage, Middle Aged, Subarachnoid Hemorrhage, Incidence, Aortic Aneurysm, Abdominal, Age Distribution, Risk Assessment, Intracranial Hemorrhage, Hypertensive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
