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Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people
Open accessAbstract
BACKGROUND: The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared. In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease. METHODS: We used linked electronic health records from 1997 to 2010 in the CALIBER (CArdiovascular research using LInked Bespoke studies and Electronic health Records) programme to assemble a cohort of 1·25 million patients, 30 years of age or older and initially free from cardiovascular disease, a fifth of whom received blood pressure-lowering treatments. We studied the heterogeneity in the age-specific associations of clinically measured blood pressure with 12 acute and chronic cardiovascular diseases, and estimated the lifetime risks (up to 95 years of age) and cardiovascular disease-free life-years lost adjusted for other risk factors at index ages 30, 60, and 80 years. This study is registered at ClinicalTrials.gov, number NCT01164371. FINDINGS: During 5·2 years median follow-up, we recorded 83,098 initial cardiovascular disease presentations. In each age group, the lowest risk for cardiovascular disease was in people with systolic blood pressure of 90-114 mm Hg and diastolic blood pressure of 60-74 mm Hg, with no evidence of a J-shaped increased risk at lower blood pressures. The effect of high blood pressure varied by cardiovascular disease endpoint, from strongly positive to no effect. Associations with high systolic blood pressure were strongest for intracerebral haemorrhage (hazard ratio 1·44 [95% CI 1·32-1·58]), subarachnoid haemorrhage (1·43 [1·25-1·63]), and stable angina (1·41 [1·36-1·46]), and weakest for abdominal aortic aneurysm (1·08 [1·00-1·17]). Compared with diastolic blood pressure, raised systolic blood pressure had a greater effect on angina, myocardial infarction, and peripheral arterial disease, whereas raised diastolic blood pressure had a greater effect on abdominal aortic aneurysm than did raised systolic pressure. Pulse pressure associations were inverse for abdominal aortic aneurysm (HR per 10 mm Hg 0·91 [95% CI 0·86-0·98]) and strongest for peripheral arterial disease (1·23 [1·20-1·27]). People with hypertension (blood pressure ≥140/90 mm Hg or those receiving blood pressure-lowering drugs) had a lifetime risk of overall cardiovascular disease at 30 years of age of 63·3% (95% CI 62·9-63·8) compared with 46·1% (45·5-46·8) for those with normal blood pressure, and developed cardiovascular disease 5·0 years earlier (95% CI 4·8-5·2). Stable and unstable angina accounted for most (43%) of the cardiovascular disease-free years of life lost associated with hypertension from index age 30 years, whereas heart failure and stable angina accounted for the largest proportion (19% each) of years of life lost from index age 80 years. INTERPRETATION: The widely held assumptions that blood pressure has strong associations with the occurrence of all cardiovascular diseases across a wide age range, and that diastolic and systolic associations are concordant, are not supported by the findings of this high-resolution study. Despite modern treatments, the lifetime burden of hypertension is substantial. These findings emphasise the need for new blood pressure-lowering strategies, and will help to inform the design of randomised trials to assess them. FUNDING: Medical Research Council, National Institute for Health Research, and Wellcome Trust.
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“High blood pressure (BP) is the single leading risk factor for cardiovascular disease worldwide,1–4”
From International Consensus on Standardized Clinic Blood Pressure Measurement – A Call to Action (2023) · cites this paper as [4]
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Citations
Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292
2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.005 · Cited by 4,945
Law, M. R., Morris, J. K., & Wald, N. J. (2009) · BMJ · doi:10.1136/bmj.b1665 · Cited by 2,775
Heart disease and stroke statistics--2013 update: a report from the American Heart Association.
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · eScholarship (California Digital Library) · Cited by 2,601
Research works printed but not linked: 1
- Gallagher, 2011, Linkage of the General Practice Research Database (GPRD) with other data sources, Pharmacoepidemiol Drug Saf, 20, S230
Cited by
Sorted by citations
Items 701–800 of 1,000
Evaluation of a hypertension-based patient education program in a stroke center
Nasr, N. B., Rouault, A., Cornillet, N., Bruandet, M., Beaussier, H., Tersen, I., Bézie, Y., & Zuber, M. (2018) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-018-0745-2 · Cited by 13
The association between high-sensitivity C-reactive protein and blood pressure in Yi people
Pan, L., Li, G., Wan, S., Yihuo, W.-L., Yang, F., Li, Z., & Shan, G. (2019) · BMC Public Health · doi:10.1186/s12889-019-7324-x · Cited by 13
Chou, C., Kung, P., Chou, W., & Tsai, W. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026626 · Cited by 14
Keeley, E. C., Villanueva, M., Chen, Y. E., Gong, Y., Handberg, E. M., Smith, S. M., Pepine, C. J., & Cooper‐DeHoff, R. M. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.14037 · Cited by 13
“Patients were randomly assigned in a 1:1 ratio to (1) unattended BP measurement, followed by attended BP measurement, or (2) attended BP measurement followed by unattended BP measurement.”
BackgroundMethodBlood Pressure and Brain Lesions in Patients With Atrial Fibrillation
Aeschbacher, S., Blum, S., Meyre, P. B., Coslovsky, M., Vischer, A. S., Sinnecker, T., Rodondi, N., Beer, J. H., Moschovitis, G., Moutzouri, E., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.16025 · Cited by 14
Firibastat: A Novel Brain Aminopeptidase Inhibitor – A New Era of Antihypertensive therapy
Gupta, R., Alcantara, R., Popli, T., Tariq, U., Sood, A., Mahajan, S., Ayele, H., Rajeswaran, Y., & Vyas, A. V. (2021) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2021.100859 · Cited by 12
Sun, X., Yao, S., Hu, S., Liu, Z.-Y., Yang, Y., Yuan, Z., Ye, W., Li, J., & Wang, X. (2016) · Sleep And Breathing · doi:10.1007/s11325-016-1392-2 · Cited by 13
“Hypertension is a clinical symptom increasing the risk for cardiovascular events, renal disease, and other adverse outcomes [1, 2].”
BackgroundLong-term predictors of stroke in healthy middle-aged men
Prestgaard, E., Hodnesdal, C., Engeseth, K., Erikssen, J., Bodegård, J., Liestøl, K., Gjesdal, K., Kjeldsen, S. E., Grundvold, I., & Berge, E. (2017) · International Journal of Stroke · doi:10.1177/1747493017730760 · Cited by 13
Optimum waveform envelopes and amplitude ratios in oscillometric blood pressure estimation
Alvarado Alvarez, M., Padwal, R., Ringrose, J., Jalali, A., & Hiebert, W. (2021) · Blood Pressure Monitoring · doi:10.1097/mbp.0000000000000485 · Cited by 12
Lopez‐Cepero, A. A., McClain, A. C., Rosal, M. C., Tucker, K. L., & Mattei, J. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001013 · Cited by 13
Online continuous measurement of arterial pulse pressure and pressure waveform using ultrasound
Xu, L., Wu, P., Xia, P., Geng, F., Lu, S., Wang, P., Chen, X., Li, Z., Du, L., Liu, S., et al. (2023) · Measurement · doi:10.1016/j.measurement.2023.113379 · Cited by 13
Todorova, Y., Wellings, I., Thompson, H., Barutcu, A., James, L. J., BISHOP, N. C., O’Donnell, E., Shaw, C. N., & Longman, D. P. (2023) · Urban Science · doi:10.3390/urbansci7030085 · Cited by 13
“Stress can also lead to poorer cardiovascular [4], cardiometabolic [5], and musculoskeletal [6] health.”
Liang, W., Liu, C., Yan, X., Hou, Y., Yang, G., Dai, J., & Wang, S. (2024) · PeerJ · doi:10.7717/peerj.17064 · Cited by 12
Eleftheriadou, V., Ahmed, A., Nesnas, J., & Nagra, R. (2024) · British Journal of Dermatology · doi:10.1093/bjd/ljae282 · Cited by 12
Rupakheti, B., Badri, K. C., Bista, D., Kc, S., & Pandey, K. R. (2024) · Patient Preference and Adherence · doi:10.2147/ppa.s476104 · Cited by 12
Karakasis, P., Lefkou, E. E., Pamporis, K., Farmakis, D. T., Patoulias, D., Antoniadis, A. P., Heymans, S. R. B., Filippatos, G. S., & Fragakis, N. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3637 · Cited by 13
Population-based approaches for reducing stroke risk
Gorelick, P. B., Farooq, M. U., & Min, J. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.987128 · Cited by 12
Rowan, C. G., Flory, J., Stempniewicz, N., Cuddeback, J. K., & Brunelli, S. M. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3849 · Cited by 12
Sera, F., Jin, Z., Russo, C. A., Lee, E. S., Schwartz, J. E., Rundek, T., Elkind, M. S. V., Homma, S., Sacco, R. L., & Tullio, M. R. D. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv188 · Cited by 12
A comparison of four stress reduction modalities on measures of stress among university students
Bennion, E., Olpin, M., & DeBeliso, M. (2018) · International Journal of Workplace Health Management · doi:10.1108/ijwhm-11-2017-0090 · Cited by 12
“Reducing SBP and DBP to ranges of 90-114 mmHg and 60-74 mmHg have been shown to have the lowest risk of cardiovascular disease (Rapsomaniki et al., 2014).”
BackgroundHypertensive urgencies and emergencies: Misconceptions and pitfalls
Angeli, F., Reboldi, G., & Verdecchia, P. (2019) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2019.10.031 · Cited by 12
Campbell, P. J., Axon, D. R., Taylor, A. M., Pickering, M. K., Black, H. L., Warholak, T. L., & Chinthammit, C. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.016094 · Cited by 13
Surrati, A. M. Q., Mohammedsaeed, W. M., & Shikieri, A. B. E. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.658243 · Cited by 12
Beyond the Skin Plaques: Psoriasis and Its Cardiovascular Comorbidities
Kakarala, C. L., Hassan, M., Belavadi, R., Gudigopuram, S. V. R., Raguthu, C. C., Gajjela, H., Kela, I., & Sange, I. (2021) · Cureus · doi:10.7759/cureus.19679 · Cited by 12
“at 30 years have a 40% increased risk of developing a cardiovascular event compared to controls of similar age and sex [38].”
BackgroundHossain, A., Ahsan, G. U., Hossain, M. Z., Hossain, M. A., Sultana, Z. Z., Arefin, A., Jahan, S. M. S., & Sutradhar, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269240 · Cited by 12
Zhou, J., Lin, J., & Zheng, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.925874 · Cited by 12
“Genetic instruments in MR should satisfy three assumptions: (Quintana and Taylor, 2019) the SNP was associated with the exposure; (Rapsomaniki et al., 2014) the SNP was not associated with confounders that can affect the causal effect of exposure on the outcome, and (Kobeissi et al.”
BackgroundMethodInfluentialHan, K., Kim, D. W., & Kim, W. (2022) · Yonsei Medical Journal · doi:10.3349/ymj.2022.0273 · Cited by 12
Health of female prisoners in Brazil
Leal, M., Kerr, L. R. F. S., Mota, R. M. S., Neto, R. D. J. P., Seal, D. W., & Kendall, C. (2022) · Ciência & Saúde Coletiva · doi:10.1590/1413-812320222712.10222022 · Cited by 12
Yang, M., Wu, K., Wu, Q., Huang, C., Xu, Z., Ho, H. C., Tao, J., Zheng, H., Hossain, M. Z., Zhang, W., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-25658-6 · Cited by 12
The Polypill: A New Alternative in the Prevention and Treatment of Cardiovascular Disease
Espinosa, E. V. P., Mato, E., Guzmán, D. M. S., & Khasawneh, F. T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113179 · Cited by 14
“…Pressure) [31], and CALIBER (CArdiovascular research using LInked Bespoke studies and Electronic health Records) studies, as well as systematic reviews and meta-analyses of RCTs [32,33], provide suitable evidence that antihypertensive treatments reduce cardiovascular events and all-cause mortality.”
BackgroundCoronary heart disease and risk factors in elderly population
Имаева, А. Э., Михайловна, Т. Е., Shalnova, S. A., & Киселева, Н. В. (2016) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2016-2-93-99 · Cited by 12
“Согласно мета-анализу [29], выполненному в 2014г, повышенное систолическое АД у лиц >60 лет ассоциировалось со стабильной стенокардией и ИМ [29].”
Namasivayam, M. J., Adji, A. I., & O’Rourke, M. F. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv080 · Cited by 12
Lisauskienė, I., Garuolienè, K., & Gulbinovič, J. (2017) · Medicina · doi:10.1016/j.medici.2017.07.004 · Cited by 12
“1136/jech-2014-204319 [24] Rapsomaniki E, Timis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, et al.”
BackgroundCombination therapies for hypertension – why we need to look beyond RAS blockers
Gorostidi, M., & de la Sierra, A. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1509705 · Cited by 12
“age above 80 years, BP above optimal levels (115/75 mmHg) is strongly related to cardiovascular disease (CVD) and overall mortality [4,5].”
BackgroundArterial stiffness mediates the effect of salt intake on systolic blood pressure
Siriopol, D. C., Covic, A. C., Iliescu, R., Kanbay, M., Tautu, O., Radulescu, L., Mitu, O., Șalaru, D. L., & Dorobanţu, M. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13399 · Cited by 12
Mehanna, M., Wang, Z., Gong, Y., McDonough, C. W., Beitelshees, A. L., Gums, J. G., Chapman, A. B., Schwartz, G. L., Bailey, K. R., Johnson, J. A., et al. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz022 · Cited by 12
Levels of Systolic and Diastolic Blood Pressure and Their Relation to Incident Metabolic Syndrome
Jung, J. Y., Oh, C., Choi, J., Ryoo, J., Chung, P., Hong, H. P., & Park, S. K. (2019) · Cardiology · doi:10.1159/000499867 · Cited by 12
Majnarić, L. T., Martinović, I., Šabanović, Š., Rudan, S., Babič, F., & Wittlinger, T. (2019) · International Journal of Hypertension · doi:10.1155/2019/9848125 · Cited by 12
Jun, M., & Kim, Y.-M. (2020) · IEEE Transactions on Instrumentation and Measurement · doi:10.1109/tim.2020.2981107 · Cited by 12
Scaling a Community-Wide Campaign Intervention to Manage Hypertension and Weight Loss
Reininger, B. M., Mitchell-Bennett, L. A., Lee, M., Yeh, P. G., Davé, A. C., Park, S. K., Xu, T., & Toro, A. G. O.-D. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.661353 · Cited by 13
Xing, L. Y., Diederichsen, S. Z., Højberg, S., Krieger, D. W., Graff, C., OLESEN, M. S., Brandes, A., Køber, L., Haugan, K., & Svendsen, J. H. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19333 · Cited by 12
Park, B. E., Lee, J. H., Jang, S. Y., Lee, H., Lee, J., Shin, H. G., Park, K., Lee, S., Lee, H., Kim, K., et al. (2022) · Journal of Clinical Hypertension · doi:10.1111/jch.14583 · Cited by 12
Time course of blood pressure control prior to lacunar TIA and stroke
Li, L., Welch, S. J. V., Gutnikov, S. A., Mehta, Z., Rothwell, P. M., & Study, O. B. O. T. O. V. (2018) · Neurology · doi:10.1212/wnl.0000000000005526 · Cited by 12
“also showed decreased associations of BP and stroke with age.(24) There are several potential explanations.”
BackgroundOse, D. J., Adediran, E., Owens, R., Gardner, E., Mervis, M., Turner, C., Carlson, E., Forbes, D., Jasumback, C. L., Stuligross, J., et al. (2023) · Journal of Medical Internet Research · doi:10.2196/42409 · Cited by 13
Personal versus therapist perioperative music intervention: a randomized controlled trial
Jiang, F., Wang, T., Hu, L., Chen, S., Chen, L., Liu, X., Lu, Y., Gu, E., & Ulloa, L. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001383 · Cited by 12
“Systolic blood pressure (SBP) normally presents a linear correlation with cardiovascular events and is consistently associated with cardiovascular disorders [40,41] .”
BackgroundResultLi, Z., He, H., Liu, J., Gu, H., Fu, C., Zeb, A., Che, T., & Shen, S. (2024) · Marine Drugs · doi:10.3390/md22090398 · Cited by 11
“Hypertension has emerged as a global health concern, affecting more than 1.13 billion people worldwide, according to a survey conducted by the World Health Organization [1].”
BackgroundInfluentialExercise and Blood Pressure Control in Hypertension
MacDonald, H. V., & Pescatello, L. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-04816-7_8 · Cited by 13
Wang, L., Chen, Z., Li, Y., Yang, J., & Li, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-42520-3 · Cited by 11
“(2), which contains blood flow location information (step 2 in Fig.”
Liu, X., Song, Q., Wu, S., Zhou, W., & Wang, X. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002607 · Cited by 11
Park, K., Kim, S., Ko, Y.-J., & Park, B. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113744 · Cited by 12
Wan, E. Y. F., Yu, E. Y. T., Chin, W. Y., Barrett, J., Wong, I. C. K., Chan, E. W., Chui, C. S. L., Chen, S., & Lam, C. L. K. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019026 · Cited by 11
“12 In addition, the association between SBP and cardiovascular diseases may vary in different age groups, 13– 15 but there is no available study evaluating the age-specific effects of usual SBP variability on CVD and mortality among patients with DM.”
ABO blood group system and occurrence of ischemic stroke
Rafaella Chiodini, L. O. T. Z., WELTER, C. D. S., RAMOS, S. A., Ferreira, L. E., CABRAL, N. L., & de FRANÇA, P. H. C. (2021) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2020-0219 · Cited by 11
Ghosh, T. K., Rehman, T., & Ahamed, F. (2021) · Cureus · doi:10.7759/cureus.19540 · Cited by 11
“Both the mechanisms result in increased BP [9,19,20].”
BackgroundMohammadi, M., Ayoobi, F., Khalili, P., Soltani, N. S., Vecchia, C. L., & Vakilian, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-03377-7 · Cited by 11
Chen, H., Zhuo, C., & Zheng, L. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.868850 · Cited by 12
Rim, D., Henderson, L. A., & Macefield, V. G. (2022) · Clinical Autonomic Research · doi:10.1007/s10286-022-00907-9 · Cited by 12
Machine learning models for predicting the risk factor of carotid plaque in cardiovascular disease
Bin, C., Li, Q., Tang, J. P., Dai, C., Jiang, T., Xie, X., Qiu, M., Chen, L., & Yang, S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1178782 · Cited by 12
Harbaoui, B., Courand, P., Milon, H., Fauvel, J., Khettab, F., Mechtouff, L., Cassar, E., Girerd, N., & Lantelme, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.011 · Cited by 11
Pharmacology in Peripheral Arterial Disease: What the Interventional Radiologist Needs to Know
Atturu, G., Homer‐Vanniasinkam, S., & Russell, D. (2014) · Seminars in Interventional Radiology · doi:10.1055/s-0034-1393969 · Cited by 11
Primary prevention of CVD: modification of diet in people with hypertension.
Padwal, R. S., Hackam, D. G., Khan, N. A., & Tobe, S. W. (2016) · Europe PMC (PubMed Central) · Cited by 11
Isaura, E. R., Chen, Y., & Yang, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081567 · Cited by 11
Qi, Z., Zhao, Z., Xu, J., Zhu, L., Zhang, Y., Bao, Y., & Zhang, Z. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3926851 · Cited by 11
Zheng, L., Dai, Y., Fu, P., Yang, T., Xie, Y., Zheng, J., Gao, J., & Niu, T. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.14060 · Cited by 11
Synthesis and vasorelaxant evaluation of novel 7-methoxyl-2,3-disubstituted-quinoxaline derivatives
Zheng, C., Gao, W., Pang, P., Ma, X., Peng, L.-C., Yang, L. Y. O., & Li, X. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.127785 · Cited by 11
Nagakura, Y., Kato, H., Asano, S., Jinno, Y., & Tanei, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020836 · Cited by 12
“Hypertension is associated with a wide range of acute and chronic cardiovascular diseases, such as angina and heart failure [22].”
BackgroundAzegami, T., Uchida, K., Arima, F., Sato, Y., Awazu, M., Inokuchi, M., Murai‐Takeda, A., Itoh, H., Tokumura, M., & Mori, M. (2021) · Hypertension Research · doi:10.1038/s41440-021-00615-3 · Cited by 11
Falkovskaya, А. Y., Mordovin, V. F., Pekarskiy, S. E., Manukyan, M. A., Ripp, T. M., Zyubanova, I. V., Lichikaki, V. A., Sitkova, E. S., Гусакова, А. М., & Baev, A. E. (2021) · Kardiologiia · doi:10.18087/cardio.2021.2.n1102 · Cited by 11
Burkitt, K. H., Rodriguez, K. L., Mor, M. K., Fine, M. J., Clark, W. J., Macpherson, D. S., Mannozzi, C. M., Muldoon, M. F., Long, J. A., & Hausmann, L. R. M. (2021) · Healthcare · doi:10.1016/j.hjdsi.2020.100485 · Cited by 11
Sharma, S., Skog, J., Timpka, S., & Ignell, C. (2021) · Pregnancy Hypertension · doi:10.1016/j.preghy.2021.09.005 · Cited by 11
Petrović, D., Marcus, K., Sandoval, J. L., Cullati, S., Piumatti, G., Bodenmann, P., Jackson, Y., Durosier, C., Wolff, H. J., Guessous, I., et al. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101602 · Cited by 11
Peripheral arterial disease and hypertension
Gupta, A., & Patel, R. A. G. (2022) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000983 · Cited by 5
Li, S., Barywani, S. B., & Fu, M. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000403 · Cited by 11
“However, a weak U-shaped association for unheralded coronary death in octogenarian patients was demonstrated recently, those with SBP equal to or less than 114 mmHg or at least 180 mmHg were at higher risk for cardiac arrest or death [31].”
BackgroundDan, Y., Yu, Z., Wang, W., & Chen, Y. (2019) · International Journal of Biometeorology · doi:10.1007/s00484-019-01780-4 · Cited by 11
Prognostic Significance of Hyponatremia in ST-elevation Myocardial Infarction/Heart Failure Patients
Shah, V., & Jahan, N. (2019) · Cureus · doi:10.7759/cureus.5673 · Cited by 11
“3 million deaths worldwide annually [2-4].”
Cardiovascular implications in adolescent and young adult hypertension
Raina, R., Khooblall, A., Shah, R., Vijayvargiya, N., Khooblall, P., Sharma, B., Datla, N., Narang, A., Yerigeri, K., Melachuri, M. K., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305166 · Cited by 14
“Aging and increasing vascular stiffness also augment pulse pressure and escalate afterload on the left ventricle [65,66,70].”
BackgroundGJD Modulates Cardiac/Vascular Inflammation and Decreases Blood Pressure in Hypertensive Rats
Mohammed, S. A. D., Liu, H., Baldi, S., Chen, P., Lü, F., & Liu, S. (2022) · Mediators of Inflammation · doi:10.1155/2022/7345116 · Cited by 10
Reston, J., Caskey, F. J., Hole, B. D., Udayaraj, U. P., & Weinman, J. A. (2023) · JMIR Formative Research · doi:10.2196/33147 · Cited by 10
“People with CKD are at an increased risk for cardiac events, and good blood pressure control can reduce this risk in people with and without CKD [11].”
BackgroundHypertension after the Menopause: What Can We Learn from Experimental Studies?
Pitha, J. V., Vaněčková, I., & Zicha, J. (2023) · Physiological Research · doi:10.33549/physiolres.935151 · Cited by 10
Medical Profile Model: Scientific and Practical Applications in Healthcare
Blinov, P. D., & Kokh, V. (2023) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2023.3321132 · Cited by 14
Fan, L., Liu, L., Zhao, Y., Mo, Y., Li, J., & Cai, L. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076694 · Cited by 10
The incidence, predictors, and causes of cardiac arrest in United States emergency departments
Hsu, S.-H., Sung, C., Lu, T., Wang, C., Chou, E. H.-C., Ko, C., Huang, C., & Tsai, C. (2023) · Resuscitation Plus · doi:10.1016/j.resplu.2023.100514 · Cited by 10
Zhu, Y., Li, C., Gao, D., Huang, X., Zhang, Y., Ji, M., Zheng, F., & Xie, W. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.91 · Cited by 10
“Debate continues on the topic of diastolic J-shape phenomenon on cardiovascular events (29, 30), and findings linking DBP levels to dementia and death also remains controversial (11, 12, 31).”
Elkomy, S., & Jackson, T. P. (2024) · Socio-Economic Planning Sciences · doi:10.1016/j.seps.2024.102043 · Cited by 14
Therapieziele bei der Hypertoniebehandlung
Düsing, R. (2017) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0043-107269 · Cited by 10
Atzema, C. L., Wong, A., Masood, S., Zia, A., Al-bulushi, S., Sohail, Q. Z., Cherry, A., & Chan, F. (2018) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2018.06.002 · Cited by 10
Sun, X., Zeng, C. C., Zhang, S.-Z., Zhou, H.-M., Zhong, X.-B., Xiong, Z.-Y., Yang, D.-Y., Guo, Y., Zhuang, X., & Liao, X.-X. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000896 · Cited by 10
Fanelli, E., Enri, L. R., Pappaccogli, M., Fasano, C., Monaco, S. D., Pignata, I., Baratta, F., Eula, E., Masera, G., Mana, M., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.01.004 · Cited by 10
Mehanna, M., McDonough, C. W., Smith, S. M., Gong, Y., Gums, J. G., Chapman, A. B., Johnson, J. A., McIntyre, L. M., & Cooper‐DeHoff, R. M. (2021) · Metabolites · doi:10.3390/metabo11090645 · Cited by 10
“Three-quarters of European American hypertensive patients have uncontrolled blood pressure (BP) despite being prescribed antihypertensive medications [1,2].”
BackgroundElevated Brain Natriuretic Peptide and High Brachial Pulse Pressure in Patients With Diabetes
Dillinger, J., Patin, C., Bonnin, P., Vidal-Trécan, T., Paven, E., Gautier, J., Riveline, J., Amah, G., & Henry, P. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpab179 · Cited by 10
Guo, J., Shi, J., Qin, M., Wang, Y., Li, Z., Shoji, T., Ikezoe, T., Ge, Y., & Xu, B. (2023) · Biomolecules · doi:10.3390/biom13060899 · Cited by 12
“In epidemiological studies, hypertension or high blood pressure was associated with a mild increase in AAA risk in retrospective but not prospective studies [66,67].”
BackgroundKim, K., Nist, K. M., Puleo, F. J., McKenna, J., & Wainford, R. D. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00150.2023 · Cited by 10
Pharmacotherapy for hypertension-induced left ventricular hypertrophy
Finizola, R. M., Infante, E., Finizola, B., Pardo, J. P., Flores, Y., Granero, R., & Arai, K. J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012039 · Cited by 10
Ericsson, A., Holst, J., Gottsäter, A., Zarrouk, M., & Kumlien, C. (2017) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2017.06.001 · Cited by 10
Duman, H., Bahçeci, İ., Çinier, G., Duman, H., Bakırcı, E. M., & Çetın, M. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1510946 · Cited by 10
“Mortality rate is almost doubled with each 20 and 10 mmHg increase in systolic and diastolic blood pressure level, respectively (1,2).”
BackgroundDiagnosis and Prevention of Hypertensive Heart Failure
Kalogeropoulos, A. P., Goulbourne, C., & Butler, J. (2019) · Heart Failure Clinics · doi:10.1016/j.hfc.2019.05.001 · Cited by 10
Kattih, B., Elling, L. S., Weiß, C., Bea, M., Zwadlo, C., Bavendiek, U., Bauersachs, J. K., & Heineke, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-46640-8 · Cited by 10
Gabiola, J., Morales, D. D., Quizon, O., Cadiz, R. I., Feliciano, K. B., Ruiz, R. L., Aguatis, C. J., Mararac, T., Rojina, J., García, A., et al. (2019) · Journal of Community Health · doi:10.1007/s10900-019-00764-0 · Cited by 10
Wanghi, G. I., Mutombo, P. B., & Sumaili, E. K. (1970) · African Health Sciences · doi:10.4314/ahs.v19i4.7 · Cited by 10
Wang, K. M., Stedman, M. R., Chertow, G. M., & Chang, T. I. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.16155 · Cited by 10
Xiao, M., Tang, X., Zhang, F., Zhou, L., Bu, X., Liu, X., Ding, X., Shen, Z., Chen, L., Wu, Y., et al. (2020) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-020-00908-y · Cited by 10
Metadata
- Authors
- Rapsomaniki, E., Timmis, A., George, J., Pujades-Rodriguez, M., Shah, A. D., Denaxas, S., White, I. R., Caulfield, M. J., Deanfield, J. E., Smeeth, L., Williams, B., Hingorani, A., & Hemingway, H.
- Affiliations
- Farr Institute (GB)
- Queen Mary University of London (GB)
- MRC Biostatistics Unit (GB)
- London School of Hygiene & Tropical Medicine (GB)
- National Institute for Health and Care Research (GB)
- Corresponding author
- Rapsomaniki, Eleni
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 383
- Issue
- 9932
- Pages
- 1899-1911
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC4042017
- OpenAlex
- W2169428949
- Cited by
- 1,643
- References
- 41
- Citations by year
- 2026: 79 · 2025: 117 · 2024: 145 · 2023: 161 · 2022: 162 · 2021: 192 · 2020: 168 · 2019: 163 · 2018: 142 · 2017: 117 · 2016: 94 · 2015: 66 · 2014: 34
- FWCI
- 71.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Lancet (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health Research (NIHR) (RP-PG-0407–10314)
- Wellcome Trust (086091/Z/08/Z, 0938/30/Z/10/Z)
- Medical Research Council Prognosis Research Strategy (PROGRESS) Partnership (G0902393/99558)
- Medical Research Council, Arthritis Research UK, British Heart Foundation, Cancer Research UK, Chief Scientist Office, Economic and Social Research Council, Engineering and Physical Sciences Research Council, NIHR, National Institute for Social Care and Health Research, and Wellcome Trust (MR/K006584/1)
- NIHR Doctoral Fellowship (DRF-2009–02–50)
- Medical Research Council (U105260558)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- blood pressure, cardiovascular disease incidence, systolic blood pressure, diastolic blood pressure, pulse pressure, lifetime risk, healthy life years lost, intracerebral hemorrhage, subarachnoid hemorrhage, myocardial infarction, stable angina, peripheral arterial disease, abdominal aortic aneurysm, stroke, hypertension, age-specific associations, blood pressure-lowering treatment, J-curve
- MeSH terms
- Acute Disease, Adult, Aged, Aged, 80 and over, Angina Pectoris, Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Chronic Disease, England, Female, Follow-Up Studies, Humans, Hypertension, Male, Medical Record Linkage, Middle Aged, Subarachnoid Hemorrhage, Incidence, Aortic Aneurysm, Abdominal, Age Distribution, Risk Assessment, Intracranial Hemorrhage, Hypertensive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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