The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia
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Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell disease. Asthma is common in children with sickle-cell disease and is associated with increased incidence of vaso-occlusive pain events, acute chest syndrome episodes, and earlier death. Risk factors for asthma exacerbation and an acute chest syndrome episode are similar, and both can present with shortness of breath, chest pain, cough, and wheezing. Despite overlapping risk factors and symptoms, an acute exacerbation of asthma or an episode of acute chest syndrome are two distinct entities that need disease-specific management strategies. Although understanding has increased about asthma as a comorbidity in sickle-cell disease and its effects on morbidity, substantial gaps remain in knowledge about best management.
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Bronchial hyper-reactivity, asthma, and chronic airway inflammation are highly prevalent in children with sickle cell disease and may result in a proinflammatory milieu that amplifies cellular and humoral immunity to airway pathogens, leading to a paroxysmal, detrimental response.
“Bronchial hyper-reactivity, asthma, and chronic airway inflammation (209) are highly prevalent in children with SCD and may result in a proinflammatory milieu that amplifies cellular and humoral immunity to airway pathogens, thus leading to a paroxysmal, detrimental response (210, 211).”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [210]
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- Authors
- DeBaun, M. R., & Strunk, R. C.
- Affiliations
- Vanderbilt University (US)
- Washington University in St. Louis (US)
- Corresponding author
- DeBaun, Michael R
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 387
- Issue
- 10037
- Pages
- 2545-2553
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC5041533
- OpenAlex
- W2431053166
- Cited by
- 82
- References
- 62
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 4 · 2021: 3 · 2020: 14 · 2019: 5 · 2018: 10 · 2017: 11 · 2016: 2 · 2014: 1
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (5R01-HL079937-08, R01HL079937)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- asthma, acute chest syndrome, sickle cell disease, asthma exacerbations, comorbidities, vaso-occlusive pain, risk factors, disease management
- MeSH terms
- Adolescent, Anemia, Sickle Cell, Anti-Bacterial Agents, Asthma, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Risk Factors, Bronchial Hyperreactivity, Age Distribution, Young Adult, Acute Chest Syndrome
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