Association between plasma free haem and incidence of vaso‐occlusive episodes and acute chest syndrome in children with sickle cell disease
Open accessAbstract
Summary: We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso‐occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08–3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The role of hemolysis in acute chest syndrome is underscored by clinical observations linking severe hemolysis to increased risk.
“The role of hemolysis in ACS is underscored by clinical observations linking severe hemolysis to increased risk (216, 217)”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [216]
The Abstract reports that higher plasma free haem was associated with increased odds of acute chest syndrome in children with sickle cell disease. Results and Discussion also links higher bilirubin, a marker of haemolysis, to ACS, but cautions that haemolysis itself may not be a major discriminator. The evidence supports an association with specific markers, not the broader claim that severe haemolysis increases risk. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pain in Sickle Cell Disease: Rates and Risk Factors
Platt, O. S., Thorington, B. D., Brambilla, D. J., Milner, P. F., Rosse, W. F., Vichinsky, E., & Kinney, T. R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107043250103 · Cited by 1,546 · see citing works
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330 · see citing works
Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease
Gladwin, M. T., Sachdev, V., Jison, M. L., Shizukuda, Y., Plehn, J. F., Minter, K., Brown, B., Coles, W. A., Nichols, J. S., Ernst, I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035477 · Cited by 1,325 · see citing works
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., et al. (2002) · Nature Medicine · doi:10.1038/nm799 · Cited by 1,097 · see citing works
Castro, O. L., Brambilla, D. J., Thorington, B. D., Reindorf, C. A., Scott, R., GILLETTE, P. N., Vera, J., & Levy, P. S. (1994) · Blood · doi:10.1182/blood.v84.2.643.643 · Cited by 805 · see citing works
Pro-oxidant and cytotoxic effects of circulating heme
Jeney, V., Balla, J., Yachie, A., Varga, Z., Vercellotti, G. M., Eaton, J. W., & Balla, G. (2002) · Blood · doi:10.1182/blood.v100.3.879 · Cited by 633 · see citing works
Castro, O. L., Brambilla, D. J., Thorington, B. D., et al. (1994) · Blood · doi:10.1182/blood.v84.2.643.bloodjournal842643 · Cited by 615 · see citing works
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, Â., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1586 · Cited by 560 · see citing works
Kinney, T. R., Helms, R. W., O’Branski, E. E., Ohene‐Frempong, K., Wang, W. C., Daeschner, C., Vichinsky, E. P., Redding‐Lallinger, R., Gee, B. E., Platt, O. S., et al. (1999) · PubMed · Cited by 417 · see citing works
Exchange of Heme among Hemoglobins and between Hemoglobin and Albumin
Bunn, H. F., & Jandl, J. H. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93628-8 · Cited by 415 · see citing works
Müller‐Eberhard, U., Javid, J., Liem, H. H., von Hanstein, A. S., & Hanna, M. (1968) · Blood · doi:10.1182/blood.v32.5.811.811 · Cited by 329 · see citing works
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
Seixas, E., Gozzelino, R., Chora, Â., Ferreira, A., Silva, G., Larsen, R., Rebelo, S., Penido, C., Smith, N. R., Coutinho, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903419106 · Cited by 275 · see citing works
Nouraie, M. S., Lee, J. S., Zhang, Y., Kanias, T., Zhao, X., Xiong, Z., Oriss, T. B., Zeng, Q., Kato, G. J., Gibbs, J. S. R., et al. (2012) · Haematologica · doi:10.3324/haematol.2012.068965 · Cited by 227 · see citing works
Pulmonary hypertension and nitric oxide depletion in sickle cell disease
Bunn, H. F., Nathan, D. G., Dover, G. J., Hebbel, R. P., Platt, O. S., Rosse, W. F., & Ware, R. E. (2010) · Blood · doi:10.1182/blood-2010-02-268193 · Cited by 200 · see citing works
Bean, C. J., Boulet, S. L., Ellingsen, D., Pyle, M., Barron‐Casella, E. A., Casella, J. F., Payne, A. B., Driggers, J., Trau, H. A., Yang, G., et al. (2012) · Blood · doi:10.1182/blood-2011-06-361642 · Cited by 83 · see citing works
Self-citationAcute Chest Syndrome In Transgenic Mouse Models of Sickle Cell Disease Triggered by Free Heme
Ghosh, S., & Ofori-Acquah, S. F. (2010) · Blood · doi:10.1182/blood.v116.21.944.944 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Pathophysiology of Sickle Cell Disease
Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813 · see citing works
Extracellular hemin crisis triggers acute chest syndrome in sickle mice
Ghosh, S., Adisa, O. A., Chappa, P., Tan, F., Jackson, K. A., Archer, D. R., & Ofori-Acquah, S. F. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64578 · Cited by 282 · see citing works
Self-citationThe intersection between asthma and acute chest syndrome in children with sickle-cell anaemia
DeBaun, M. R., & Strunk, R. C. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00145-8 · Cited by 82 · see citing works
- Authors
- Adisa, O. A., Hu, Y., Ghosh, S., Aryee, D., Osunkwo, I., & Ofori‐Acquah, S. F.
- Affiliations
- Emory University (US)
- Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University Atlanta GA USA
- Division of Hematology, Oncology and Bone Marrow Transplantation Department of Pediatrics Emory University School of Medicine Emory University Atlanta GA USA
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2013-06-27
- Volume
- 162
- Issue
- 5
- Pages
- 702-705
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- PMC
- PMC3745813
- OpenAlex
- W2031998621
- Cited by
- 88
- References
- 16
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 9 · 2016: 12 · 2015: 7 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- British Journal of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Aflac
- National Heart, Lung, and Blood Institute (R01HL106192, K02HL088026, U01HL117721)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- sickle cell disease, vaso-occlusive crisis, acute chest syndrome, children, disease complications, risk factors
- MeSH terms
- Adolescent, Anemia, Sickle Cell, Arterial Occlusive Diseases, Child, Child, Preschool, Female, Heme, Humans, Male, Biomarkers, Acute Chest Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
