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Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study
Open accessAbstract
Background There is a need to increase access to surgical treatments in African countries, but perioperative complications represent a major global health-care burden. There are few studies describing surgical outcomes in Africa.Methods We did a 7-day, international, prospective, observational cohort study of patients aged 18 years and older undergoing any inpatient surgery in 25 countries in Africa (the African Surgical Outcomes Study). We aimed to recruit as many hospitals as possible using a convenience sampling survey, and required data from at least ten hospitals per country (or half the surgical centres if there were fewer than ten hospitals) and data for at least 90% of eligible patients from each site. Each country selected one recruitment week between February and May, 2016. The primary outcome was in-hospital postoperative complications, assessed according to predefined criteria and graded as mild, moderate, or severe. Data were presented as median (IQR), mean (SD), or n (%), and compared using t tests. This study is registered on the South African National Health Research Database (KZ_2015RP7_22) and ClinicalTrials.gov (NCT03044899).Findings We recruited 11 422 patients (median 29 [IQR 10-70]) from 247 hospitals during the national cohort weeks. Hospitals served a median population of 810 000 people (IQR 200 000-2 000 000), with a combined number of specialist surgeons, obstetricians, and anaesthetists totalling 0·7 (0·2-1·9) per 100 000 population. Hospitals did a median of 212 (IQR 65-578) surgical procedures per 100 000 population each year. Patients were younger (mean age 38·5 years [SD 16·1]), with a lower risk profile (American Society of Anesthesiologists median score 1 [IQR 1-2]) than reported in high-income countries. 1253 (11%) patients were infected with HIV, 6504 procedures (57%) were urgent or emergent, and the most common procedure was caesarean delivery (3792 patients, 33%). Postoperative complications occurred in 1977 (18·2%, 95% CI 17·4-18·9]) of 10 885 patients. 239 (2·1%) of 11 193 patients died, 225 (94·1%) after the day of surgery. Infection was the most common complication (1156 [10·2%] of 10 970 patients), of whom 112 (9·7%) died.Interpretation Despite a low-risk profile and few postoperative complications, patients in Africa were twice as likely to die after surgery when compared with the global average for postoperative deaths. Initiatives to increase access to surgical treatments in Africa therefore should be coupled with improved surveillance for deteriorating physiology in patients who develop postoperative complications, and the resources necessary to achieve this objective.Funding Medical Research Council of South Africa.
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“The study was done according to STROBE guidelines for observational studies.17”
From Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study (2020) · cites this paper as [17]
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Metadata
- Authors
- Biccard, B. M., Madiba, T. E., Kluyts, H.-L., Munlemvo, D. M., Madzimbamuto, F. D., Basenero, A., Gordon, C. S., Youssouf, C., Rakotoarison, S. R., Gobin, V., Samateh, A. L., Sani, C. M., Omigbodun, A. O., Amanor-Boadu, S. D., Tumukunde, J. T., Esterhuizen, T. M., Manach, Y. L., Forget, P., Elkhogia, A. M., Mehyaoui, R. M., Zoumeno, E., Ndayisaba, G., Ndasi, H., Ndonga, A. K. N., Ngumi, Z. W. W., Patel, U. P., Ashebir, D. Z., Antwi-Kusi, A. A. K., Mbwele, B., Sama, H. D., Elfiky, M., Fawzy, M. A., Pearse, R. M., Abadagan, H., Abbas, N., Abdelatif, A. I., Abdoulaye, T., Abd-rouf, A., Abduljalil, A., Abdulrahman, A., Abdurazig, S., Abokris, A., Abozaid, W., Abugassa, S., Abuhdema, F., Abujanah, S., Abusamra, R., Abushnaf, A., Abusnina, S., Abuzalout, T., Ackermann, H., Adamu, Y., Addanfour, A., Adeleke, D., Adigun, T., Adisa, A., Adjignon, S. V., Adu-Aryee, N., Afolabi, B., Agaba, A., Agaba, P., Aghadi, K., Agilla, H., Ahmed, B., Ahmed, E.-Z., Ahmed, A.-J., Ahmed, M., Ahossi, R., Aji, S., Akanyun, S., Akhideno, I., Akhter, M., Akinyemi, O., Akkari, M., Akodjenou, J., AL Samateh, A., al Shams, E., Alagbe-Briggs, O., Alakkari, E., Alalem, R., Alashhab, M., Alatise, O., Alatresh, A., Alayeb Alayeb, M., Albakosh, B., Albert, F., Alberts, A., Aldarrat, A., Alfari, A., Alfetore, A., Algbali, M., Algddar, A., Algedar, H., Alghafoud, I., Alghazali, A., Alhajj, M., Alhendery Alhendery, A., Alhoty, F., Ali, A., Ali, Y., Ali, A., Alioune, B. S., Alkassem, M., Alkchr, M., Alkesa, T., Alkilani, A., Alkobty Alkobty, F., Allaye, T., Alleesaib, S., Alli, A., Allopi, K., Allorto, N., Almajbery, A., Almesmary, R., Almisslati, S., Almoraid, F., Alobeidi, H., Alomami, M., Alphonsus, C. S., Alqawi, O., Alraheem, A., Alsabri, S., Alsayed, A., Alsellabi, B., Al-Serksi, M., Alshareef, M., Altagazi, A., Aluvale, J., Alwahedi, H., Alzahra, E., Alzarouk, M., Al-Zubaidy, K., Amadou, M., Amadou, M., Amanor-Boadu, S. D., Amer, A.-A., Amisi, B., Amuthenu, M., Anabah, T., Anani, F., Anderson, P., Andriamampionona, A., Andrianina, L., Anele, A., Angelin, R., Anjar, N., Antùnez, O., Antwi-Kusi, A., Anyanwu, L., Aribi, A., Arowolo, O., Arrey, O., Ashebir, D. Z., Assefa, S., Assoum, G., Athanse, V, Athombo, J., Atiku, M., Atito-Narh, E., Atomabe, A., Attia, A., Aungraheeta, M., Aurélia, D., Ayandipo, O., Ayebale, A., Azzaidey, H., Babajee, N., Badi, H., Badianga, E., Baghni, R., Bahta, M., Bai, M., Baitchu, Y., Baloyi, A., Bamuza, K., Bamuza, M., Bangure, L., Bankole, O., Barongo, M., Barow, M., Basenero, A., Bashiya, L., Basson, C., Bechan, S., Belhaj, S., Ben Mansour, M., Benali, D., Benamour, A., Berhe, A., Bertie, J., Bester, J., Bester, M., Bezuidenhout, J., Bhagwan, K., Bhagwandass, D., Bhat, K., Bhuiyan, M., Biccard, B. M., Bigirimana, F., Bikuelo, C., Bilby, B., Bingidimi, S., Bischof, K., Bishop, D. G., Bitta, C., Bittaye, M., Biyase, T., Blake, C., Blignaut, E., Blignaut, F., BN Tanjong, B., Bogoslovskiy, A., Boloko, P., Boodhun, S., Bori, I., Boufas, F., Brand, M., Brouckaert, N. T., Bruwer, J., Buccimazza, I., Bula Bula, I., Bulamba, F., Businge, B., Bwambale, Y., Cacala, S., Cadersa, M., Cairns, C., Carlos, F., Casey, M., Castro, A., Chabayanzara, N., Chaibou, M., Chaibva, T., Chakafa, N., Chalo, C., Changfoot, C., Chari, M., Chelbi, L., Chibanda, J., Chifamba, H., Chikh, N., Chikumba, E., Chimberengwa, P., Chirengwa, J., Chitungo, F., Chiwanga, M., Chokoe, M., Chokwe, T., Chrirangi, B., Christian, M., Church, B., Cisekedi, J., Clegg-Lamptey, J., Cloete, E., Coltman, M., Conradie, W., Constance, N., Coulibaly, Y., Cronje, L., Da Silva, M., Daddy, H., Dahim, L., Daliri, D., Dambaki, M., Dasrath, A., Davids, J., Davies, G. L., De Lange, J., de Wet, J., Dedekind, B., Degaulle, M., Dehal, V, Deka, P., Delinikaytis, S., Desalu, I., Dewanou, H., Deye, M. M., Dhege, C., Diale, B., Dibwe, D., Diedericks, B., Dippenaar, J., Dippenaar, L., Diyoyo, M., Djessouho, E., Dlamini, S., Dodiyi-Manuel, A., Dokolwana, B., Domoyyeri, D., Drummond, L. W., du Plessis, D., du Plessis, W., du Preez, L., Dube, K., Dube, N., Dullab, K., Duvenhage, R., Echem, R., Edaigbini, S., Egote, A., Ehouni, A., Ekwen, G., Ekwunife, N., El Hensheri, M., Elfaghi, I., Elfagieh, M., Elfallah, S., Elfiky, M., Elgelany, S., Elghallal, A., Elghandouri, M., Elghazal, Z., Elghobashy, A., Elharati, F., Elkhogia, A. M., Elkhwildi, R., Ellis, S., Elmadani, L., Elmadany, H., Elmehdawi, H., Elmgadmi, A., Eloi, H., Elrafifi, D., Elsaadi, G., Elsaity, R., Elshikhy, A., Eltaguri, M., Elwerfelli, A., Elyasir, I., Elzoway, A., Elzufri, A., Enendu, E., Enicker, B., Enwerem, E., Esayas, R., Eshtiwi, M., Eshwehdi, A., Esterhuizen, J., Esterhuizen, T. M., Etuk, E., Eurayet, O., Eyelade, O., Fanjandrainy, R., Fanou, L., Farina, Z., Fawzy, M., Feituri, A., Fernandes, N., Ford, L., Forget, P., François, T., Freeman, T., Freeman, Y., Gacii, V., Gadi, B., Gagara, M., Gakenia, A., Gallou, P., Gama, G., Gamal, M., Gandy, Y., Ganesh, A., Gangaly, D., Garcia, M., Gatheru, A., Gaya, S., Gbéhadé, O., Gerbel, G., Ghnain, A., Gigabhoy, R., Giles, D., Girmaye, G., Gitau, S., Githae, B., Gitta, S., Gobin, V., Goga, R., Gomati, A., Gonzalez, M., Gopall, J., Gordon, C. S., Gorelyk, O., Gova, M., Govender, K., Govender, P., Govender, S., Govindasamy, V, Green-Harris, J., Greenwood, M., Grey-Johnson, S., Grobbelaar, M., Groenewald, M., Grünewald, K., Guegni, A., Guenane, M., Gueye, S., Guezo, M., Gunguwo, T., Gweder, M., Gwila, M., Habimana, L., Hadecon, R., Hadia, E., Hamadi, L., Hammouda, M., Hampton, M., Hanta, R., Hardcastle, T. C., Hariniaina, J., Hariparsad, S., Harissou, A., Harrichandparsad, R., Hasan, S., Hashmi, H., Hayes, M., Hdud, A., Hebli, S., Heerah, H., Hersi, S., Hery, A., Hewitt-Smith, A., Hlako, T., Hodges, S., Hodgson, R. E., Hokoma, M., Holder, H., Holford, E., Horugavye, E., Houston, C., Hove, M., Hugo, D., Human, C., Hurri, H., Huwidi, O., Ibrahim, A., Ibrahim, T., Idowu, O., Igaga, I., Igenge, J., Ihezie, O., Ikandi, K., Ike, I., Ikuku, J., Ilbarasi, M., Ilunga, I., Ilunga, J., Imbangu, N., Imessaoudene, Z., Imposo, D., Iraya, A., Isaacs, M., Isiguzo, M., Issoufou, A., Izquirdo, P., Jaber, A., Jaganath, U., Jallow, C., Jamabo, S., Jamal, Z., Janneh, L., Jannetjies, M., Jasim, I., Jaworska, M. A., Jay Narain, S., Jermi, K., Jimoh, R., Jithoo, S., Johnson, M., Joomye, S., Judicael, R., Judicaël, M., Juwid, A., Jwambi, L., Kabango, R., Kabangu, J., Kabatoro, D., Kabongo, A., Kabongo, K., Kabongo, L., Kabongo, M., Kady, N., Kafu, S., Kaggya, M., Kaholongo, B., Kairuki, P., Kakololo, S., Kakudji, K., Kalisa, A., Kalisa, R., Kalufwelu, M., Kalume, S., Kamanda, R., Kangili, M., Kanoun, H., Kapesa, Kapp, P., Karanja, J., Karar, M., Kariuki, K., Kaseke, K., Kashuupulwa, P., Kasongo, K., Kassa, S., Kateregga, G., Kathrada, M., Katompwa, P., Katsukunya, L., Kavuma, K., Khalfallah, Khamajeet, A., Khetrish, S., Kibandwa, Kibochi, W., Kilembe, A., Kintu, A., Kipng'etich, B., Kiprop, B., Kissoon, V., Kisten, T. K., Kiwanuka, J., Kluyts, H.-L., Knox, M., Koledale, A., Koller, V., Kolotsi, M., Kongolo, M., Konwuoh, N., Koperski, W., Koraz, M., Kornilov, A., Koto, M. Z., Kransingh, S., Krick, D., Kruger, S., Kruse, C., Kuhn, W., Kuhn, W., Kukembila, A., Kule, K., Kumar, M., Kusel, B. S., Kusweje, V., Kuteesa, K., Kutor, Y., Labib, M., Laksari, M., Lanos, F., Lawal, T., Le Manach, Y., Lee, C., Lekoloane, R., Lelo, S., Lerutla, B., Lerutla, M., Levin, A., Likongo, T., Limbajee, M., Linyama, D., Lionnet, C., Liwani, M., Loots, E., Lopez, A. G., Lubamba, C., Lumbala, K., Lumbamba, A., Lumona, J., Lushima, R., Luthuli, L., Luweesi, H., Lyimo, T., Maakamedi, H., Mabaso, B., Mabina, M., Maboya, M., Macharia, I., Macheka, A., Machowski, A., Madiba, T. E., Madsen, A., Madzimbamuto, F., Madzivhe, L., Mafafo, S., Maghrabi, M., Mahamane, D. D., Maharaj, A., Maharaj, A., Maharaj, A., Mahmud, M., Mahoko, M., Mahomedy, N., Mahomva, O., Mahureva, T., Maila, R., Maimane, D., Maimbo, M., Maina, S., Maiwald, D. A., Maiyalagan, M., Majola, N., Makgofa, N., Makhanya, V, Makhaye, W., Makhlouf, N., Makhoba, S., Makopa, E., Makori, O., Makupe, A. M., Makwela, M., Malefo, M., Malongwe, S., Maluleke, D., Maluleke, M., Mamadou, K. T., Mamaleka, M., Mampangula, Y., Mamy, R., Mananjara, M., Mandarry, M., Mangoo, D., Manirimbere, C., Manneh, A., Mansour, A., Mansour, I., Manvinder, M., Manyere, D., Manzini, V., Manzombi, J., Mapanda, P., Marais, L., Maranga, O., Maritz, J., Mariwa, F., Masela, R., Mashamba, M., Mashava, D. M., Mashile, M., Mashoko, E., Masia, O., Masipa, J., Masiyambiri, A., Matenchi, M., Mathangani, W., Mathe, R., Matola, C. Y., Matondo, P., Matos-Puig, R., Matoug, F., Matubatuba, J., Mavesere, H., Mavhungu, R., Maweni, S., Mawire, C., Mawisa, T., Mayeza, S., Mbadi, R., Mbayabu, M., Mbewe, N., Mbombo, W., Mbuyi, T., Mbuyi, W., Mbuyisa, M., Mbwele, B., Mehyaoui, R., Menkiti, I., Mesarieki, L., Metali, A., Mewanou, S., Mgonja, L., Mgoqo, N., Mhatu, S., Mhlari, T., Miima, S., Milod, I., Minani, P., Mitema, F., Mlotshwa, A., Mmasi, J., Mniki, T., Mofikoya, B., Mogale, J., Mohamed, A., Mohamed, A., Mohamed, A., Mohamed, S., Mohamed, S., Mohamed, T., Mohamed, A., Mohamed, A., Mohamed, A., Mohamed, P., Mohammed, I., Mohammed, F., Mohammed, M., Mohammed, N., Mohlala, M., Mokretar, R., Molokoane, F., Mongwe, K., Montenegro, L., Montwedi, O., Moodie, Q., Moopanar, M., Morapedi, M., Morulana, T., Moses, V., Mossy, P., Mostafa, H., Motilall, Sr., Motloutsi, S., Moussa, K., Moutari, M., Moyo, O., Mphephu, P., Mrara, B., Msadabwe, C., Mtongwe, V., Mubeya, F., Muchiri, K., Mugambi, J., Muguti, G., Muhammad, A., Mukama, I., Mukenga, M., Mukinda, F., Mukuna, P., Mungherera, A., Munlemvo, D. M., Munyaradzi, T., Munyika, A., Muriithi, J., Muroonga, M., Murray, R., Mushangwe, V., Mushaninga, M., Musiba, V., Musowoya, J., Mutahi, S., Mutasiigwa, M., Mutizira, G., Muturi, A., Muzenda, T., Mvwala, K., Mvwama, N., Mwale, A., Mwaluka, C., Mwamba, J., Mwanga, H., Mwangi, C., Mwansa, S., Mwenda, V, Mwepu, I., Mwiti, T., Mzezewa, S., Nabela, L., Nabukenya, M., Nabulindo, S., Naicker, K., Naidoo, D., Naidoo, L., Naidoo, L., Naidoo, N., Naidoo, R., Naidoo, R., Naidoo, S., Naidoo, T., Naidu, T., Najat, N., Najm, Y., Nakandungile, F., Nakangombe, P., Namata, C., Namegabe, E., Nansook, A., Nansubuga, N., Nantulu, C., Nascimento, R., Naude, G., Nchimunya, H., Ndaie, M., Ndarukwa, P., Ndasi, H., Ndayisaba, G., Ndegwa, D., Ndikumana, R., Ndonga, A. K., Ndung'u, C., Neil, M., Nel, M., Neluheni, E., Nesengani, D., Nesengani, N., Netshimboni, L., Ngalala, A., Ngari, B., Ngari, N., Ngatia, E., Ngcobo, G., Ngcobo, T., Ngorora, D., Ngouane, D., Ngugi, K., Ngumi, Z. 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F., Roura, H., Rousseau, F., Rousseau, N., Royas, L., Roytowski, D., Rungan, D., Rwehumbiza, S., Ryabchiy, B., Ryndine, V, Saaiman, C., Sabwa, H., Sadat, S., Saed, S., Salaheddin, E., Salaou, H., Saleh, M., Salisu-Kabara, H., Sama, H. D., Samateh, A. L., Sam-Awortwi (Jnr), W., Samuel, N., Sanduku, D., Sani, C. M., Sanyang, L., Sarah, H., Sarkin-Pawa, A., Sathiram, R., Saurombe, T., Schutte, H., Sebei, M., Sedekounou, M., Segooa, M., Semenya, E., Semo, B., Sendagire, C., Senoga, S., Senusi, F., Serdyn, T., Seshibe, M., Shah, G., Shamamba, R., Shambare, C., Shangase, T., Shanin, S., Shefren, I., Sheshe, A., Shittu, O., Shkirban, A., Sholadoye, T., Shubba, A., Sigcu, N., Sihope, S., Sikazwe, D., Sikombe, B., Simaga Abdoul, K., Simo, W., Singata, K., Singh, A., Singh, S., Singh, U., Sinoamadi, V, Sipuka, N., Sithole, N., Sitima, S., Skinner, D. 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- Affiliations
- University Teaching Hospital (ZM)
- Cairo University (EG)
- Centre Hospitalier Universitaire de Tokoin (TG)
- Sefako Makgatho Health Sciences University (ZA)
- Christian Social Services Commission (TZ)
- Addis Ababa University (ET)
- University College Hospital, Ibadan (NG)
- Queen Mary University of London (GB)
- Republic of Burundi (BI)
- National Hospital Niamey (NE)
- University of Nairobi (KE)
- Ministry of Health and Quality of Life (MU)
- University of Zimbabwe (ZW)
- University of Ibadan (NG)
- Ministry of Health and Social Services (NA)
- Kwame Nkrumah University of Science and Technology (GH)
- Population Health Research Institute (CA)
- Makerere University (UG)
- University of Cape Town (ZA)
- University of KwaZulu-Natal (ZA)
- Tripoli Central Hospital (LY)
- Stellenbosch University (ZA)
- University of Bamako (ML)
- Vrije Universiteit Brussel (BE)
- ORCID
- Abusamra, R
- Abushnaf, A
- Ahmed, M
- Alli, A
- Alphonsus, Christella S
- Anele, A
- Attia, A
- Bai, M
- Bhuiyan, MMZU
- Bishop, David G
- Bittaye, M
- Blignaut, E
- Buccimazza, I
- Bulamba, Fred
- Carlos, F
- Changfoot, C
- Chimberengwa, P
- Chokwe, TM
- Cloete, Estie
- Conradie, W
- Davies, Gareth L
- Drummond, Leanne W
- Ekwen, G
- Elmehdawi, H
- Fanou, Lionelle
- Farina, Z
- Ganesh, A
- Govender, K
- Govender, P
- Govindasamy, V
- Gwila, M
- Harrichandparsad, R
- Hodgson, Richard Eric
- Jaber, A
- Jaganath, UV
- Jasim, I
- Jaworska, Megan AJ
- Kabongo, K
- Kalisa, R
- Kapp, P
- Karar, M
- Kariuki, K
- Kathrada, MIS
- Khamajeet, A
- Kisten, Theroshnie K
- Kolotsi, MA
- Kruse, C
- Kumar, M
- Mahoko, M
- Maimbo, M
- Mansour, I
- Marais, LC
- Mayeza, S
- Minani, P
- Mohammed, M
- Mongwe, KN
- Montwedi, OD
- Mwenda, V
- Naicker, K
- Naidoo, N
- Nnaji, C
- Ogunbode, O
- Ogutu, O
- Otokwala, J
- Peter, A Mallier
- Porrill, Owen S
- Rademeyer, M
- Ray, S
- Rocher, S
- Rodseth, Reitze N
- Roytowski, D
- Saleh, M
- Sathiram, R
- Sholadoye, T
- Sigcu, N
- Singh, S
- Singh, Usha
- Skinner, David Lee
- Spijkerman, Sandra
- Steyn, G
- Taiwo, NA
- Tarhuni, A
- Tchaou, Blaise
- Tun, M
- Umeh, KU
- Usenbo, AO
- Wise, Robert D
- Yousef, G
- Yunus, AA
- Zidan, A
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 391
- Issue
- 10130
- Pages
- 1589-1598
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2782431511
- Cited by
- 580
- References
- 38
- Citations by year
- 2026: 44 · 2025: 68 · 2024: 59 · 2023: 72 · 2022: 85 · 2021: 76 · 2020: 88 · 2019: 49 · 2018: 37
- FWCI
- 59.59
- Type
- journal article
- Language
- en
- Open access
- green
- qmro.qmul.ac.uk
- Licence
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by-nc-nd)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- National Institute for Health and Care Research (RP_2014-04-022)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Surgery
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
- Keywords
- perioperative complications, postoperative complications, surgical outcomes, Africa, inpatient surgery, cesarean section, surgical access, healthcare workers, HIV infection, emergency surgery, postoperative mortality, postoperative hospital stay, resource-limited settings
- MeSH terms
- Adult, Africa, Cesarean Section, Female, Cardiac Surgical Procedures, Hospitals, Humans, Male, Middle Aged, Mortality, Postoperative Complications, Postoperative Period, Pregnancy, Prospective Studies, Severity of Illness Index, Digestive System Surgical Procedures, Gynecologic Surgical Procedures, Surgical Procedures, Operative, Urologic Surgical Procedures, Surgical Wound Infection, Vascular Surgical Procedures, Global Health, Cohort Studies, Logistic Models, Outcome Assessment, Health Care, Thoracic Surgical Procedures, Neurosurgical Procedures, Orthopedic Procedures, Young Adult
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