The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Management strategies and future directions for systemic lupus erythematosus in adults
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of self-tolerance and formation of nuclear autoantigens and immune complexes resulting in inflammation of multiple organs. The clinical presentation of SLE is heterogeneous, can involve one or more organs, including the skin, kidneys, joints, and nervous system, and take a chronic or relapsing and remitting disease course. SLE is most common in women and in those of non-white ethnicity. Because of the multitude of presentations, manifestations, and serological abnormalities in patients with SLE, diagnosis can be challenging. Therapeutic approaches predominantly involve immunomodulation and immunosuppression and are targeted to the specific organ manifestation, with the aim of achieving low disease activity. Despite many treatment advances and improved diagnostics, SLE continues to cause substantial morbidity and premature mortality. Current management strategies, although helpful, are limited by high failure rates and toxicity. An overreliance on corticosteroid therapy contributes to much of the long-term organ damage. In this Seminar, we outline the classification criteria for SLE, current treatment strategies and medications, the evidence supporting their use, and explore potential future therapies.
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Cites
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Self-citationDerivation of the sledai. A disease activity index for lupus patients
Bombardier, C., Gladman, D. D., Urowitz, M. B., Caron, D., Chang, C. H., Austin, A., Bell, A., Bloch, D. A., Corey, P. N., Decker, J. L., et al. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350606 · Cited by 4,570
Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus
Arbuckle, M. R., McClain, M. T., Rubertone, M. V., Scofield, R. H., Dennis, G. J., James, J. A., & Harley, J. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021933 · Cited by 2,578
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Self-citationThe Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Weening, J. J., D’Agati, V. D., Schwartz, M. M., Seshan, S. V., Alpers, C. E., Appel, G. B., Balow, J. E., Bruijn, J. A., Cook, T., Ferrario, F., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000108969.21691.5d · Cited by 2,008
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Self-citationHahn, B. H., McMahon, M. A., Wilkinson, A., Wallace, W. D., Daikh, D. I., FitzGerald, J. D., Karpouzas, G. A., Merrill, J. T., Wallace, D. J., Yazdany, J., et al. (2012) · Arthritis Care & Research · doi:10.1002/acr.21664 · Cited by 1,463
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Cited by
Tian, J., Zhang, D., Yao, X., Huang, Y., & Lu, Q. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223035 · Cited by 620
Autoimmunity and organ damage in systemic lupus erythematosus
Tsokos, G. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0677-6 · Cited by 580
Song, Y., Li, J., & Wu, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01952-8 · Cited by 259
Teng, Y., Yan, Z.-Y., Wang, L.-L., Wang, Y.-H., Zhang, T.-Y., Li, Z., Liu, S., Cai, J., Chen, Y.-F., Li, M., et al. (2022) · Rheumatology · doi:10.1093/rheumatology/keab806 · Cited by 5
Metadata
- Authors
- Durcan, L., O'Dwyer, T., & Petri, M.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 393
- Issue
- 10188
- Pages
- 2332-2343
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2948214599
- Cited by
- 648
- References
- 143
- FWCI
- 40.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Durcan, L., O'Dwyer, T., & Petri, M. (2019). Management strategies and future directions for systemic lupus erythematosus in adults. The Lancet. https://doi.org/10.1016/s0140-6736(19)30237-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
