The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia
Open accessAbstract
Opioids are a mainstay of acute pain management but can have many adverse effects, contributing to problematic long-term use. Opioid tolerance (increased dose needed for analgesia) and opioid-induced hyperalgesia (paradoxical increase in pain with opioid administration) can contribute to both poorly controlled pain and dose escalation. Hyperalgesia is particularly problematic as further opioid prescribing is largely futile. The mechanisms of opioid tolerance and hyperalgesia are complex, involving μ opioid receptor signalling pathways that offer opportunities for novel analgesic alternatives. The intracellular scaffold protein β-arrestin-2 is implicated in tolerance, hyperalgesia, and other opioid side-effects. Development of agonists biased against recruitment of β-arrestin-2 could provide analgesic efficacy with fewer side-effects. Alternative approaches include inhibition of peripheral μ opioid receptors and blockade of downstream signalling mechanisms, such as the non-receptor tyrosine kinase Src or N-methyl-D-aspartate receptors. Furthermore, it is prudent to use multimodal analgesic regimens to reduce reliance on opioids during the perioperative period. In the third paper in this Series we focus on clinical and mechanism-based understanding of tolerance and opioid-induced hyperalgesia, and discuss current and future strategies for pain management.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vos, T., Allen, C., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, A., Carter, A., Casey, D. C., Charlson, F. J., Chen, A. Z., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31678-6 · Cited by 7,253
Enhanced Recovery After Surgery: A Review
Ljungqvist, O., Scott, M., & Fearon, K. C. (2017) · JAMA Surgery · doi:10.1001/jamasurg.2016.4952 · Cited by 3,564
Chou, R., Turner, J. A., Devine, E. B., Hansen, R. N., Sullivan, S. D., Blazina, I., Dana, T., Bougatsos, C., & Deyo, R. A. (2015) · Annals of Internal Medicine · doi:10.7326/m14-2559 · Cited by 1,606
The Clinical Opiate Withdrawal Scale (COWS)
Wesson, D. R., & Ling, W. (2003) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2003.10400007 · Cited by 1,120
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
Bohn, L. M., Lefkowitz, R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., & Lin, F.-T. (1999) · Science · doi:10.1126/science.286.5449.2495 · Cited by 1,077
NeuPSIG guidelines on neuropathic pain assessment
Haanpää, M., Attal, N., Backonja, M., Baron, R., Bennett, M., Bouhassira, D., Cruccu, G., Hansson, P., Haythornthwaite, J. A., Iannetti, G. D., et al. (2011) · Pain · doi:10.1016/j.pain.2010.07.031 · Cited by 1,060
Krebs, E. E., Gravely, A., Nugent, S., Jensen, A. C., DeRonne, B., Goldsmith, E. S., Kroenke, K., Bair, M. J., & Noorbaloochi, S. (2018) · JAMA · doi:10.1001/jama.2018.0899 · Cited by 983
Structure-based discovery of opioid analgesics with reduced side effects
Manglik, A., Lin, H., Aryal, D. K., McCorvy, J. D., Dengler, D., Corder, G., Levit, A., Kling, R. C., Bernat, V., Hübner, H., et al. (2016) · Nature · doi:10.1038/nature19112 · Cited by 944
Rates and risk factors for prolonged opioid use after major surgery: population based cohort study
Clarke, H., Soneji, N., Ko, D. T., Yun, L., & Wijeysundera, D. N. (2014) · BMJ · doi:10.1136/bmj.g1251 · Cited by 940
Transition from acute to chronic pain after surgery
Glare, P., Aubrey, K. R., & Myles, P. S. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30352-6 · Cited by 914
Cited by
Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain
Hersh, E. V., Moore, P. A., Grosser, T., Polomano, R. C., Farrar, J. T., Saraghi, M., Juska, S. A., Mitchell, C. H., & Theken, K. N. (2020) · Journal of Dental Research · doi:10.1177/0022034520914254 · Cited by 106
Ketamine; history and role in anesthetic pharmacology
Hirota, K., & Lambert, D. G. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109171 · Cited by 73
Unveil the pain of endometriosis: from the perspective of the nervous system
Fan, P., & Li, T. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.26 · Cited by 20
Metadata
- Authors
- Colvin, L. A., Bull, F., & Hales, T. G.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 393
- Issue
- 10180
- Pages
- 1558-1568
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2940404939
- Cited by
- 559
- References
- 117
- FWCI
- 71.00
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia. https://app.cochat.ai/papers/10.1016/s0140-6736(19)30430-1
- The paper
- Colvin, L. A., Bull, F., & Hales, T. G. (2019). Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia. The Lancet. https://doi.org/10.1016/s0140-6736(19)30430-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
