The DOI matches its Crossref record; 135 of the 137 references it cites were found in a registry or an index.
Anxiety disorders
Open accessAbstract
Anxiety disorders form the most common group of mental disorders and generally start before or in early adulthood. Core features include excessive fear and anxiety or avoidance of perceived threats that are persistent and impairing. Anxiety disorders involve dysfunction in brain circuits that respond to danger. Risk for anxiety disorders is influenced by genetic factors, environmental factors, and their epigenetic relations. Anxiety disorders are often comorbid with one another and with other mental disorders, especially depression, as well as with somatic disorders. Such comorbidity generally signifies more severe symptoms, greater clinical burden, and greater treatment difficulty. Reducing the large burden of disease from anxiety disorders in individuals and worldwide can be best achieved by timely, accurate disease detection and adequate treatment administration, scaling up of treatments when needed. Evidence-based psychotherapy (particularly cognitive behavioural therapy) and psychoactive medications (particularly serotonergic compounds) are both effective, facilitating patients' choices in therapeutic decisions. Although promising, no enduring preventive measures are available, and, along with frequent therapy resistance, clinical needs remain unaddressed. Ongoing research efforts tackle these problems, and future efforts should seek individualised, more effective approaches for treatment with precision medicine.
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“In an effort to cope with the discomfort of intense anxiety and panic, individuals with anxiety disorders often rely on maladaptive coping behaviors, such as anxious avoidance, substance use, and maladaptive emotion regulation strategies [11].”
From Correlates of Quality of Life in Anxiety Disorders: Review of Recent Research (2021) · cites this paper as [11]
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“Comorbidity in anxiety disorders is associated with more severe symptoms, a more chronic course, and greater functional impairment [11, 26, 28].”
From Correlates of Quality of Life in Anxiety Disorders: Review of Recent Research (2021) · cites this paper as [11]
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“Epidemiological research indicates that anxiety disorders have a high ratio of 1-year lifetime prevalence, suggesting a chronic recurrent course [11].”
From Correlates of Quality of Life in Anxiety Disorders: Review of Recent Research (2021) · cites this paper as [11]
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Citations
Cites
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Self-citationDevelopment and validation of the Penn State Worry Questionnaire
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Sleep and anxiety: From mechanisms to interventions
Chellappa, S. L., & Aeschbach, D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101583 · Cited by 509
How COVID-19 shaped mental health: from infection to pandemic effects
Penninx, B. W. J. H., Benros, M. E., Klein, R. S., & Vinkers, C. H. (2022) · Nature Medicine · doi:10.1038/s41591-022-02028-2 · Cited by 480
Self-citationCandidate biomarkers in psychiatric disorders: state of the field
Abi‐Dargham, A., Moeller, S. J., Ali, F., DeLorenzo, C., Domschke, K., Horga, G., Jutla, A., Kotov, R., Paulus, M. P., Rubio, J. M., et al. (2023) · World Psychiatry · doi:10.1002/wps.21078 · Cited by 421
Xiong, R.-G., Li, J., Jin, C. S., Zhou, D.-D., Wu, S.-X., Huang, S., Saimaiti, A., Yang, Z.-J., Gan, R., & Li, H. (2023) · Nutrients · doi:10.3390/nu15143258 · Cited by 304
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases
Chen, L., Shen, Q., Liu, Y., Zhang, Y., Sun, L., Ma, X., Song, N., & Xie, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02071-0 · Cited by 279
Metadata
- Authors
- Penninx, B. W., Pine, D. S., Holmes, E. A., & Reif, A.
- Affiliations
- GGZ inGeest (NL)
- National Institute of Mental Health (US)
- Uppsala University (SE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Penninx, Brenda WJH
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 397
- Issue
- 10277
- Pages
- 914-927
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC9248771
- OpenAlex
- W4211110355
- Cited by
- 740
- References
- 137
- Citations by year
- 2026: 162 · 2025: 192 · 2024: 196 · 2023: 114 · 2022: 63 · 2021: 13
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Update notices
- erratum (2021-03-06)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (ZIAMH002781)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- anxiety disorders, avoidance, brain circuits, genetic risk factors, environmental risk factors, epigenetics, comorbidities, depression, somatic diseases, disease burden, early detection, cognitive behavioral therapy, serotonergic medications, treatment resistance, prevention, precision medicine
- MeSH terms
- Anxiety Disorders, Humans, Psychotherapy, Psychotropic Drugs, Comorbidity
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