Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science
Open accessAbstract
The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.
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The paper says there is an urgent need for the discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic.
“There is an urgent need for the discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of this pandemic.”
Quote in the paperNot yet classified - Finding
The paper states that repeated media exposure to infectious-disease information can exacerbate stress responses, amplify worry, and impair functioning.
“Repeated media exposure to information about an infectious disease particularly can exacerbate stress responses, amplify worry, and impair functioning.”
Quote in the paperNot yet classified0 of 1 sources checked- cites [82] Thompson, 2017, Distress, worry, and functioning following a global health crisis: a national study of Americans' responses to Ebola, Clin Psychol Sci source
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- Finding
The paper says the immediate research priority is to better understand repeated media consumption around COVID-19 in amplifying distress and mental ill-health and the optimal patterns of consumption to promote wellbeing.
“The immediate research priority is to better understand the role of repeated media consumption around COVID-19 in amplifying distress and mental ill-health in various groups, and the optimal patterns of consumption to promote wellbeing.”
Quote in the paperNot yet classified - Finding
Increasing people's confidence and clarity about what they need to do fosters adherence to health behaviours and can help them manage psychological distress.
“Increasing people's confidence and clarity in what they need to do fosters adherence to health behaviours,90 and can help people to manage psychological distress.”
Quote in the paperNot yet classified0 of 1 sources checked- cites [90] Peters, 2013, Threatening communication: a critical re-analysis and a revised meta-analytic test of fear appeal theory, Health Psychol Rev source
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- Finding
The authors say there is an urgent need to study how mental health consequences for vulnerable groups can be mitigated under pandemic conditions.
“There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions,”
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- Finding
The paper says immediate research should include collecting high-quality data on the mental health and psychological effects of the pandemic across the whole population and in vulnerable groups, and on brain function, cognition, and mental health in patients with COVID-19.
“The immediate priority is the collection of high-quality data on the mental health and psychological effects of the COVID-19 pandemic across the whole population and in specific vulnerable groups, and on brain function, cognition, and mental health for patients with COVID-19 at all clinical stages of infection and illness.”
Quote in the paperNot yet classified - Finding
Repeated media consumption and health messaging about COVID-19 are identified as important research targets.
“and on the impact of repeated media consumption and health messaging around COVID-19.”
Quote in the paperNot yet classified - Finding
The paper argues for discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic.
“Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required.”
Quote in the paperNot yet classified - Finding
The authors argue that multidisciplinary mental health science research must be central to the international response to the COVID-19 pandemic.
“Multidisciplinary mental health science research must be central to the international response to the COVID-19 pandemic, given the potential effects on individual and population mental health, and its potential effect on the brain function of some of those affected by the disease.”
Quote in the paperNot yet classified - Finding
The paper says immediate research on COVID-19 health messaging is urgently required to optimise behaviour change and reduce unintended mental health issues.
“Immediate research on COVID-19 health messaging is urgently required to both optimise health behaviour change and to reduce unintended mental health issues, which will be required in the event of a second wave of infection.”
Quote in the paperNot yet classified - Finding
The immediate research priorities include reducing mental health issues and supporting wellbeing in vulnerable groups.
“The immediate research priorities are to reduce mental health issues and support wellbeing in vulnerable groups in particular.”
Quote in the paperNot yet classified - Finding
During extraordinary circumstances, symptoms of anxiety and stress coping responses are expected to rise, and clinically relevant anxiety, depression, harmful behaviours, self-harm, and suicide may increase.
“Although a rise in symptoms of anxiety and coping responses to stress are expected during these extraordinary circumstances, there is a risk that prevalence of clinically relevant numbers of people with anxiety, depression, and engaging in harmful behaviours (such as suicide and self-harm) will increase.”
Quote in the paperNot yet classified - Finding
The paper identifies collecting high-quality data on mental health effects across the whole population and vulnerable groups, and on brain function, cognition, and mental health in patients with COVID-19, as an immediate priority.
“An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19.”
Quote in the paperNot yet classified - Method
The authors call for research to foster positive social resources, resilience, and altruism.
“We need research to foster positive social resources, resilience, and altruism.”
Quote in the paperNot yet classified - Method
The paper recommends collecting high-quality data rapidly to ascertain the effects of lockdown and social isolation over time.
“We need to gather high-quality data rapidly to ascertain the effects of lockdown and social isolation over time.”
Quote in the paperNot yet classified - Background
The paper says that changes in sleep and lifestyle behaviours influence mental health and stress response.
“Changes in sleep and lifestyle behaviours influence our mental health and stress response.”
Quote in the paperNot yet classified - Background
Population-level factors such as social distancing measures affect mental health within a syndemics approach.
“Population-level factors, such as the effect of social distancing measures (more recently being redescribed as physical distancing)57 and other necessary public health measures, affect mental health within a syndemics approach”
Quote in the paperNot yet classified0 of 1 sources checked- cites [57] Wasserman, 2020, Terms ‘physical distancing’ and ‘emotional closeness’ should be used and not ‘social distancing’ when defeating the Covid-19 pandemic, Science
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- Method
The paper says innovative research is needed to mitigate and manage mental health risks and inform interventions under pandemic conditions.
“Innovative research is needed to establish ways to mitigate and manage mental health risks and inform interventions under pandemic conditions.”
Quote in the paperNot yet classified - Background
The pandemic is having pervasive direct and indirect psychological and social effects that could affect mental health now and in the future.
“the direct and indirect psychological and social effects of the coronavirus disease 2019 (COVID-19) pandemic are pervasive and could affect mental health now and in the future.”
Quote in the paperNot yet classified - Method
The paper proposes immediate priorities and longer-term strategies for mental health science research on COVID-19.
“We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research.”
Quote in the paperNot yet classified - Background
Behavioural change for COVID-19 control requires that people know what to do, are motivated to do it, and have the skills and opportunity to enact the behaviours.
“Behavioural change—such as the three personal protective behaviours of handwashing, not touching the T-zone of the face, and tissue use, and social or physical distancing required to control the pandemic—necessitates ensuring people know what to do, are motivated to do it, and have the skills and opportunity to enact the changed behaviours.”
Quote in the paperNot yet classified - Method
The authors urge UK research funding agencies to establish a high-level coordination group to ensure the research priorities are addressed and new ones identified over time.
“We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time.”
Quote in the paperNot yet classified - Method
The structure of a mentally healthy life for individuals in the wake of COVID-19 needs to be mapped out.
“The optimal structure of a mentally healthy life for individuals in the wake of COVID-19 needs to be mapped out.”
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Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The threat to health and the economic downturn associated with the COVID-19 pandemic incur a tremendous burden on the population's mental health.
“The threat to health and the economic downturn associated with the COVID-19 pandemic incur a tremendous burden on the population’s mental health19.”
From A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest (2023) · cites this paper as [19]
The Introduction says the pandemic’s psychological and social effects are pervasive and could affect mental health. The section on anxiety and depression says an economic downturn is likely to have a profound mental-health impact, but specifies those directly affected and their caregivers; it does not establish the claimed tremendous burden across the population as a fact. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPublic health officials have raised concerns about the potential for massive mental health impact based on increased stress associated with fear of contracting/transmitting the virus and substantial changes to routine, financial ramifications, and social isolation.
“Alongside physical health concerns, public health officials have raised concerns about the potential for massive mental health impact based on increased stress associated with fear of contracting/transmitting the virus and substantial changes to routine, financial ramifications, and social isolation (Holmes et al., 2020; Pfefferbaum and North, 2020; Yao et al., 2020).”
From Ahead of the Curve: Responses From Patients in Treatment for Obsessive-Compulsive Disorder to Coronavirus Disease 2019 (2020) · cites this paper as Holmes et al., 2020
The Introduction and the sections on anxiety and social isolation describe potentially pervasive mental-health effects, including stress linked to infection fears, disrupted routines, financial strain, and isolation. However, the paper presents these as concerns raised by survey respondents and mental-health researchers; the cited passages do not establish that public health officials raised them. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn the absence or ambiguity of information, people contribute to the spread of misinformation or disinformation.
“Moreover, in the absence or ambiguity of information, people contribute to the spread of misinformation [169] or disinformation, a subject of much recent attention [170-172].”
From Impact of Media-Induced Uncertainty on Mental Health: Narrative-Based Perspective. (2025) · cites this paper as [171]
In the section on COVID-19 media consumption (page unavailable), the paper describes rapidly disseminated misinformation on social media and calls for strategies to minimise people’s sharing of it. It says uncertainty can drive additional media consumption, but does not say that absent or ambiguous information causes people to spread misinformation. Citation [169] is attached to the misinformation portion of the sentence, not the separately cited disinformation portion. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe COVID-19 pandemic, through combined health risk, mass disruption, and isolation, has the potential to cause substantial negative mental health outcomes.
“The combined health-risk, mass disruption and isolation caused by the COVID-19 pandemic has the potential for substantial negative mental health outcomes (Holmes et al., 2020; Kelly, 2020; Mucci et al., 2020).”
From Behind the masks: A cross-sectional study on intolerance of uncertainty, perceived vulnerability to disease and psychological flexibility in relation to state anxiety and wellbeing during the COVID-19 pandemic (2021) · cites this paper as Holmes et al., 2020
Telemental health services may effectively provide relief and combat the psychological impact of restrictive measures.
“Telemental health services may be an effective way to provide relief to those affected and to combat the psychological impact of the restrictive measures (Holmes et al., 2020; Roncero et al., 2020; Zhou et al., 2020).”
From Therapeutic Factors and Member Satisfaction in an Online Group Intervention During the COVID-19 Pandemic (2021) · cites this paper as Holmes et al., 2020
Many researchers have reported an increase in anxiety and depression owing to the ongoing pandemic.
“Many researchers have also reported an increase in anxiety and depression owing to the ongoing pandemic (Alkwiese Sr et al., 2020; Holmes et al., 2020; Liang et al., 2020; Liu X. et al., 2020; Rajkumar, 2020; Roy et al., 2020; Sood, 2020; Varshney et al., 2020).”
From Knowledge of COVID-19 and Its Influence on Mindfulness, Cognitive Emotion Regulation and Psychological Flexibility in the Indian Community (2020) · cites this paper as Holmes et al., 2020
The study included respondents from more than 60 countries, which addresses underrepresentation in recent research.
“The strength of this study is that it included respondents from more than 60 countries. It has been noted that several countries and communities have been underrepresented in recent research,(Holmes et al., 2020) and the current study was able to overcome this issue by surveying participants from a range of different countries.”
From Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: a global cross-sectional survey (2021) · cites this paper as Holmes et al., 2020
The current findings suggest that the COVID-19 pandemic causes negative mental health consequences, especially in vulnerable groups.
“The current findings suggest that the COVID-19 pandemic causes negative consequences for mental health especially in vulnerable groups (e.g. young adults, individuals with a mental disorder) which may need special attention and support by implementing interventions or prevention programs to mitigate long-term consequences for mental health (Holmes et al., 2020).”
From Lockdown, quarantine measures, and social distancing: Associations with depression, anxiety and distress at the beginning of the COVID-19 pandemic among adults from Germany (2020) · cites this paper as Holmes et al., 2020
The review found negative psychological impacts of mass quarantine, such as low life satisfaction, emotional isolation and fear of infection.
“Consistent with previous studies,10,36,37 our review presents a range of negative psychological impacts of mass quarantine, such as low life satisfaction, emotional isolation and fear of infection.23–25,30,32,34,35”
From Social consequences of mass quarantine during epidemics: a systematic review with implications for the COVID-19 response (2020) · cites this paper as [36]
The practical impact of the COVID-19 crisis is far greater than the actual number of infection cases or fatalities.
“Therefore, the practical impact of the crisis is far greater than the actual number of infection cases or fatalities [8,9].”
From Psychosocial Effects of the COVID-19 Pandemic: Large-scale Quasi-Experimental Study on Social Media (2020) · cites this paper as [9]
Scientists have warned that COVID-19 will have unprecedented effects on mental health.
“Scientists have warned that COVID-19 will have unprecedented effects on mental health [10,17]”
From “I Hate This”: A Qualitative Analysis of Adolescents' Self-Reported Challenges During the COVID-19 Pandemic (2021) · cites this paper as [10]
Researchers have called for incorporating youth perspectives of COVID-19 public health regulations.
“Researchers have called for incorporating and understanding youth perspectives of COVID-19 public health regulations when considering policy changes and understanding the pandemic’s effects [9,10].”
From “I Hate This”: A Qualitative Analysis of Adolescents' Self-Reported Challenges During the COVID-19 Pandemic (2021) · cites this paper as [10]
Quarantine influences people's daily behavior, causing anxiety, fear, depression, and panic.
“Studies show that this situation influences people's daily behavior, causing anxiety, fear, depression, and panic. 4 , 5”
From Social isolation and its impact on child and adolescent development: a systematic review (2022) · cites this paper as [4]
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Says who? The significance of sampling in mental health surveys during COVID-19.
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- Authors
- Holmes, E. A., O'Connor, R. C., Perry, V. H., Tracey, I., Wessely, S., Arseneault, L., Ballard, C., Christensen, H., Cohen Silver, R., Everall, I., Ford, T., John, A., Kabir, T., King, K., Madan, I., Michie, S., Przybylski, A. K., Shafran, R., Sweeney, A., Worthman, C. M., Yardley, L., Cowan, K., Cope, C., Hotopf, M., & Bullmore, E.
- Affiliations
- Uppsala University (SE)
- UK Dementia Research Institute (GB)
- University of Oxford (GB)
- King's College London (GB)
- University of Exeter (GB)
- Black Dog Institute (AU)
- University of Cambridge (GB)
- Swansea University (GB)
- McPin Foundation (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University College London (GB)
- St George's, University of London (GB)
- Emory University (US)
- University of Bristol (GB)
- Academy of Medical Sciences (GB)
- Corresponding author
- Cope, Claire
- ORCID
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 7
- Issue
- 6
- Pages
- 547-560
- ISSN
- 2215-0366 (ISSN-L)
- PMC
- PMC7159850
- OpenAlex
- W3015197879
- Cited by
- 5,715
- References
- 135
- Citations by year
- 2026: 103 · 2025: 218 · 2024: 468 · 2023: 795 · 2022: 1173 · 2021: 1807 · 2020: 1131 · 2019: 6 · 2018: 1 · 2014: 1 · 2013: 1
- FWCI
- 96.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion, cc-by-nc-nd)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Research Portal (King's College London) (acceptedVersion, other-oa)
- Open Research Exeter (University of Exeter) (acceptedVersion, cc-by-nc-nd)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- Minerva Access (University of Melbourne) (submittedVersion)
- Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion, public-domain)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- National Institute for Health and Care Research
- Leverhulme Trust
- National Science Foundation (SES-2026337)
- British Academy
- Oak Foundation
- Chief Scientist Office
- Huo Family Foundation
- Economic and Social Research Council
- National Institute for Health Research Southampton Biomedical Research Centre
- Department for Business, Energy and Industrial Strategy, UK Government
- John Fell Fund, University of Oxford
- Scottish Government
- Uppsala Universitet
- NIHR Maudsley Biomedical Research Centre
- Medical Research Foundation
- Medical Research Council
- University of Cambridge
- NHS Health Scotland
- Vetenskapsrådet
- Lupina Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Social Sciences › Safety Research › Social impacts of COVID-19
- Keywords
- COVID-19 pandemic, mental health research priorities, psychological effects of COVID-19, vulnerable populations, mental health interventions, research coordination, research funding, people with lived experience, multidisciplinary research, international cooperation
- MeSH terms
- COVID-19, Mental Disorders, Humans, Pneumonia, Viral, Research, Coronavirus Infections, Pandemics
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