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Low back pain
Open accessAbstract
Low back pain covers a spectrum of different types of pain (eg, nociceptive, neuropathic and nociplastic, or non-specific) that frequently overlap. The elements comprising the lumbar spine (eg, soft tissue, vertebrae, zygapophyseal and sacroiliac joints, intervertebral discs, and neurovascular structures) are prone to different stressors, and each of these, alone or in combination, can contribute to low back pain. Due to numerous factors related to low back pain, and the low specificity of imaging and diagnostic injections, diagnostic methods for this condition continue to be a subject of controversy. The biopsychosocial model posits low back pain to be a dynamic interaction between social, psychological, and biological factors that can both predispose to and result from injury, and should be considered when devising interdisciplinary treatment plans. Prevention of low back pain is recognised as a pivotal challenge in high-risk populations to help tackle high health-care costs related to therapy and rehabilitation. To a large extent, therapy depends on pain classification, and usually starts with self-care and pharmacotherapy in combination with non-pharmacological methods, such as physical therapies and psychological treatments in appropriate patients. For refractory low back pain, a wide range of non-surgical (eg, epidural steroid injections and spinal cord stimulation for neuropathic pain, and radiofrequency ablation and intra-articular steroid injections for mechanical pain) and surgical (eg, decompression for neuropathic pain, disc replacement, and fusion for mechanical causes) treatment options are available in carefully selected patients. Most treatment options address only single, solitary causes and given the complex nature of low back pain, a multimodal interdisciplinary approach is necessary. Although globally recognised as an important health and socioeconomic challenge with an expected increase in prevalence, low back pain continues to have tremendous potential for improvement in both diagnostic and therapeutic aspects. Future research on low back pain should focus on improving the accuracy and objectivity of diagnostic assessments, and devising treatment algorithms that consider unique biological, psychological, and social factors. High-quality comparative-effectiveness and randomised controlled trials with longer follow-up periods that aim to establish the efficacy and cost-effectiveness of low back pain management are warranted.
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“Multiple biological, psychological, and social risk factors contribute to the persistence of somatic symptoms”
From Persistent physical symptoms: definition, genesis, and management (2024) · cites this paper as [49]
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“Currently, the biopsychosocial model is the most recommended paradigm for the treatment and prevention of NBP [54].”
From Prevention of non-specific back pain through exercise and education: A systematic review and meta-analysis (2024) · cites this paper as [54]
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James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32279-7 · Cited by 13,867
Raja, S. N., Carr, D. B., Cohen, M., Finnerup, N. B., Flor, H., Gibson, S., Keefe, F. J., Mogil, J. S., Ringkamp, M., Sluka, K. A., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000001939 · Cited by 5,223
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931
Self-citationPharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70251-0 · Cited by 3,980
Qaseem, A., Wilt, T. J., McLean, R. M., Forciea, M. A., & for the Clinical Guidelines Committee of the American College of Physicians* (2017) · Annals of Internal Medicine · doi:10.7326/m16-2367 · Cited by 3,234
A systematic review of the global prevalence of low back pain
Hoy, D. G., Bain, C. J., Williams, G. M., MARCH, L. M., Brooks, P., Blyth, F., Woolf, A. D., Vos, T., & Buchbinder, R. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34347 · Cited by 3,025
Maher, C., Underwood, M., & Buchbinder, R. (2017) · The Lancet · doi:10.1016/s0140-6736(16)30970-9 · Cited by 2,535
Prevention and treatment of low back pain: evidence, challenges, and promising directions
Foster, N. E., Anema, J. R., Cherkin, D., Chou, R., Cohen, S. P., Gross, D. P., Ferreira, P. H., Fritz, J. M., Koes, B. W., Peul, W., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30489-6 · Cited by 2,398
Self-citationThe Stabilizing System of the Spine. Part I. Function, Dysfunction, Adaptation, and Enhancement
Panjabi, M. M. (1992) · Journal of Spinal Disorders · doi:10.1097/00002517-199212000-00001 · Cited by 2,180
Lumbar Disc Disorders and Low-Back Pain: Socioeconomic Factors and Consequences
Katz, J. N. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.e.01273 · Cited by 1,655
Research works printed but not linked: 2
- Jordan, 2011, Herniated lumbar disc, BMJ Clin Evid, 2011
- Huang, 2016, Risk factors for recurrent lumbar disc herniation: a systematic review and meta-analysis, Medicine, 95
Cited by
Sorted by citations
Items 101–200 of 1,000
Smoking, alcohol and coffee consumption and risk of low back pain: a Mendelian randomization study
Lv, Z., Cui, J., & Zhang, J. (2022) · European Spine Journal · doi:10.1007/s00586-022-07389-3 · Cited by 33
Zhang, W., Chen, Z., Su, Z., Wang, Z., Hai, J., Huang, C., Wang, Y., Yan, B., & Lü, H. (2023) · JOR Spine · doi:10.1002/jsp2.1276 · Cited by 29
Huang, Z., Wang, Z.-Y., Cheng, X., Huang, Z.-Z., Han, Y., Cui, Y., Liu, B., & Tian, W. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.10.002 · Cited by 30
Li, H., Tian, L., Li, J., Li, Y., Du, L., Huo, Z., & Xu, B. (2022) · Analytical Cellular Pathology · doi:10.1155/2022/9550499 · Cited by 30
Lan, T., Hu, Z., Guo, W., Yan, B., & Zhang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2481071 · Cited by 30
Zhou, X., Kong, L., Ren, J. P., Song, P., Wu, Z., He, T., Lv, Z., Zhang, S., Sun, W., Zhang, J., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.952346 · Cited by 33
Yang, S., Zhang, Y., Peng, Q., Meng, B., Wang, J., Sun, H., Chen, L., Dai, R., & Zhang, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116001 · Cited by 33
Russo, F., Ambrosio, L., Giannarelli, E., Vorini, F., Mallio, C. A., Quattrocchi, C. C., Vadalà, G., Papalia, R., & Denaro, V. (2023) · The Spine Journal · doi:10.1016/j.spinee.2023.05.011 · Cited by 32
Hu, X., Tian, X., Yang, C., Ling, F., Liu, H., Zhu, X., Pei, M., Yang, H., Liu, T., Xu, Y. X., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100811 · Cited by 29
Zhao, J., Zheng, L., Dai, G., Sun, Y. E., He, R., Liu, Z., Jin, Y., Wu, T., Hu, J., Cao, Y. B., et al. (2024) · The Spine Journal · doi:10.1016/j.spinee.2024.09.017 · Cited by 34
Wang, J., Zhu, L., Shi, P., Wang, P.-C., Dai, Y., Wang, Y., Lu, X., Cheng, X., Feng, X., & Zhang, L. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1427110 · Cited by 29
Yang, J., Ou, Z., Mao, Z., Wang, Y., Zhong, Y., Dong, W., Shen, Z. Z., & Chen, Z. (2022) · Scientific Reports · doi:10.1038/s41598-022-22220-1 · Cited by 33
Zheng, F., Zheng, Y., Liu, S., Yang, J., Xiao, W., Xiao, W., Chen, L., Yang, W., Zhang, S., Yu, Q., et al. (2022) · Pain and Therapy · doi:10.1007/s40122-022-00358-0 · Cited by 27
Yoshimoto, Y., & Oishi, Y. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108357 · Cited by 28
Hu, S., Zhu, M., Xing, H., Xue, Y., Li, J., Wang, Z., Zhu, Z., Fang, M., Li, Z., Xu, J., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.03.006 · Cited by 29
Wu, J., Han, W., Zhang, Y., Li, S., Qin, T., Huang, Z., Zhang, C., Shi, M., Wu, Y., Zheng, W., et al. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0384 · Cited by 28
Stimuli-Responsive Delivery Systems for Intervertebral Disc Degeneration
Tang, J., Luo, Y., Wang, Q., Wu, J., & Wei, Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s463939 · Cited by 28
Wang, J., Huang, Y., Luan, T., Shi, P., Guo, L., Zhang, Q., Shi, G., Hao, Z., Chen, T., Zhang, L., et al. (2024) · Small · doi:10.1002/smll.202404732 · Cited by 28
Guo, Z., Wang, X., Sun, J., Chen, Q., Chen, L., Wu, O., Jin, Y., Lyu, T., Morgan, J., Li, Y. M., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202403892 · Cited by 29
Intradiscal injection for the management of low back pain
Zhang, F., Wang, S., Li, B., Tian, W., Zhou, Z., & Liu, S. (2021) · JOR Spine · doi:10.1002/jsp2.1186 · Cited by 28
Pourahmadi, M., Delavari, S., Hayden, J. A., Keshtkar, A., Ahmadi, M., Aletaha, A., Nazemipour, M., Mansournia, M. A., & Rubinstein, S. M. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-104926 · Cited by 33
Yang, N., Di, J., Wang, W., & Feng, H. (2025) · BMC Public Health · doi:10.1186/s12889-025-23178-1 · Cited by 28
Schmid, S., Bangerter, C., Schweinhardt, P., & Meier, M. L. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.715219 · Cited by 29
Hernández-Lucas, P., Leirós‐Rodríguez, R., Lopez-Barreiro, J., & Soidán, J. L. G. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2140453 · Cited by 29
Su, M., Tang, Y., Kong, W., Zhang, S., & Zhu, T. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1157451 · Cited by 29
Zhang, K., Du, L., Li, Z., Huo, Z., Shen, L., Gao, S., Jia, Y., Zhu, M., & Xu, B. (2024) · Biomaterials Research · doi:10.34133/bmr.0047 · Cited by 26
Advancing skeletal health and disease research with single-cell RNA sequencing
Lin, P., Gan, Y., He, J., Lin, S., Xu, J., Chang, L., Zhao, L., Zhu, J. J., Zhang, L., Huang, S., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00538-3 · Cited by 26
Jia, S., Liu, H., Yang, T., Gao, S., Li, D., Zhang, Z., Zhang, Z., Gao, X., Liang, Y., Liang, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78675-x · Cited by 33
Zhou, X., Zhu, D., Wu, D., Li, G., Liang, H., Zhang, W., Wu, Y., Xu, H., Zhang, Z., Tong, B., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102079 · Cited by 27
Hu, Q., Li, H., Ye, Z., Wei, Z., & Ao, J. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100523 · Cited by 26
Diez-Buil, H., Hernandez-Lucas, P., Leirós-Rodríguez, R., & Echeverría-García, O. (2023) · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · doi:10.1002/ijgo.15000 · Cited by 27
Xu, H.-W., Fang, X., Liu, X., Zhang, S., Yi, Y., Chang, S.-J., Chen, H., & Wang, S. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00280.2023 · Cited by 25
Jiang, H., Qin, H., Yang, Q., Huang, L., Liang, X. Q., Wang, C., Moro, A., Xu, S., & Wei, Q. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02561-x · Cited by 25
Wu, Z., Wang, K.-P., Chen, Y., Song, W., Liu, Y., Zhou, K., Mao, P., Ma, Z., & Zhang, H.-H. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.015 · Cited by 25
New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain
Yan, M., Song, Z., Kou, H., Shang, G., Shang, C., Chen, X., Ji, Y., Bao, D., Cheng, T., Li, J., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.866857 · Cited by 25
Concerns about cell therapy for intervertebral disc degeneration
Peng, B., & Li, Y. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00245-4 · Cited by 25
Fish consumption, omega-3 fatty acid intake, and risk of pain: the Seniors-ENRICA-1 cohort
Carballo‐Casla, A., García‐Esquinas, E., Banegas, J. R., Rodríguez‐Artalejo, F., & Ortolá, R. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.09.007 · Cited by 25
Zhang, J., Zhang, W., Sun, T., Wang, J., Li, Y., Liu, J., & Li, Z. (2022) · Stem Cells International · doi:10.1155/2022/8671482 · Cited by 26
Application of platelet-rich plasma in spinal surgery
Wang, H., Zhu, J., Xia, Y., Li, Y., & Fu, C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1138255 · Cited by 25
Zhou, D., Liu, H., Zheng, Z., & Wu, D. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.08.012 · Cited by 25
Xue, B., Peng, Y., Zhang, Y., Yang, S., Zheng, Y., Hu, H.-L., Gao, X., Yu, B., Gao, X., Li, S., et al. (2024) · Advanced Science · doi:10.1002/advs.202408093 · Cited by 24
Taylor, W., & Erwin, W. M. (2024) · Cells · doi:10.3390/cells13242103 · Cited by 24
Mitochondrial quality control: the real dawn of intervertebral disc degeneration?
Qiu, B., Xie, X., & Xi, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05943-9 · Cited by 28
Penchev, R., Scheuring, R. A., Soto, A. T., Miletich, D. M., Kerstman, E. L., & Cohen, S. P. (2021) · Anesthesiology · doi:10.1097/aln.0000000000003812 · Cited by 24
Self-citation3. Pain originating from the lumbar facet joints
van den Heuvel, S. A. S., Cohen, S. P., Ares, J. D. A., Boxem, K. V., Kallewaard, J. W., & Zundert, J. H. M. V. (2023) · Pain Practice · doi:10.1111/papr.13287 · Cited by 24
Self-citationLópez-Marcos, J. J., Díaz‐Arribas, M. J., Valera‐Calero, J. A., Navarro‐Santana, M. J., Izquierdo-García, J., Ortiz-Gutiérrez, R. M., & Plaza‐Manzano, G. (2024) · Sensors · doi:10.3390/s24020567 · Cited by 23
Expandable Cages for Lumbar Interbody Fusion: A Narrative Review
Lee, S., Yoon, J., Park, S., & Chae, D. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102889 · Cited by 23
Qin, T., Shi, M., Zhang, C., Wu, J., Huang, Z., Zhang, X., Li, S., Wu, Y., Han, W., Gao, B., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01345-5 · Cited by 23
Petrucci, G., Papalia, G. F., Ambrosio, L., Russo, F., Marchetti, A., Marinis, M. G. D., Vadalà, G., Papalia, R., & Denaro, V. (2025) · European Spine Journal · doi:10.1007/s00586-025-08733-z · Cited by 29
Xiao, C., Zhao, Y., Li, G., Zhang, Z., Liu, S., Fan, W., Hu, J., Yao, Q., Yang, C., Zou, J., et al. (2025) · JMIR mhealth and uhealth · doi:10.2196/56176 · Cited by 27
Reyes‐Ferrada, W., Chirosa-Rios, L., García, D. M., Perea, Á. R., & Jerez‐Mayorga, D. (2022) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-210261 · Cited by 24
Biomechanical Phenotyping of Chronic Low Back Pain: Protocol for BACPAC
Quirk, D. A., Johnson, M. E., Anderson, D., Smuck, M. W., Sun, R., Matthew, R. P., Bailey, J. F., Marras, W. S., Bell, K. M., Darwin, J., et al. (2022) · Pain Medicine · doi:10.1093/pm/pnac163 · Cited by 23
Yuan, L., Huang, Z., Han, W., Chang, R., Sun, B., Zhu, M., Li, C., Yan, J., Liu, B., Yin, H., et al. (2023) · BMC Public Health · doi:10.1186/s12889-023-16224-3 · Cited by 23
Zheng, D., Kawchuk, G. N., Bussières, A., Zoubi, F. A., Hartvigsen, J., Fu, S. N., de Luca, K. E., Weiner, D. K., Karppinen, J. I., Samartzis, D., et al. (2023) · Journal of Pain Research · doi:10.2147/jpr.s425672 · Cited by 23
Zhang, T., Chen, W.-K., Huang, X., Zheng, B., Wu, P.-F., Zheng, B., Jiang, L., Escobar, D., Li, J., Lv, G., et al. (2024) · Translational research · doi:10.1016/j.trsl.2024.05.011 · Cited by 23
Bastiaens, F., van de Wijgert, I. H., Bronkhorst, E. M., van Roosendaal, B.-K. W. P., van Heteren, E. P. Z., Gilligan, C. J., Staats, P. S., Wegener, J. T., van Hooff, M. L., & Vissers, K. C. P. (2024) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2023.10.188 · Cited by 24
Acute low back pain: Epidemiology, etiology, and prevention: WFNS spine committee recommendations
Oertel, J., Sharif, S. Y., Zygourakis, C. C., & Sippl, C. (2024) · World Neurosurgery X · doi:10.1016/j.wnsx.2024.100313 · Cited by 22
Sima, S., & Diwan, A. D. (2025) · JOR Spine · doi:10.1002/jsp2.70021 · Cited by 22
Mangano, N., Torpey, A. P., Devitt, C., Wen, G. A., Doh, C., & Gupta, A. (2025) · Biomedicines · doi:10.3390/biomedicines13051091 · Cited by 22
Alcaraz-Clariana, S., García-Luque, L., Garrido-Castro, J. L., Aranda-Valera, I. C., Ladehesa-Pineda, L., Puche-Larrubia, M. Á., Carmona-Pérez, C., Rodrigues‐de‐Souza, D. P., & Alburquerque‐Sendín, F. (2021) · Diagnostics · doi:10.3390/diagnostics11101898 · Cited by 22
Postural Control of Patients with Low Back Pain Under Dual-Task Conditions
Xiao, W., Yang, H., Wang, Z., Mao, H., Wang, H.-J., Hao, Z., Zu, Y., & Wang, C. (2023) · Journal of Pain Research · doi:10.2147/jpr.s392868 · Cited by 22
Hartmann, R., Avermann, F., Zalpour, C., & Griefahn, A. (2023) · Health Science Reports · doi:10.1002/hsr2.1060 · Cited by 23
Sobański, D., Staszkiewicz, R., Stachura, M. K., Gadzieliński, M., & Grabarek, B. O. (2023) · Medical Science Monitor · doi:10.12659/msm.939237 · Cited by 22
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling
Meng, Q., Liu, K., Liu, Z., Liu, J., Tian, Z., Qin, S., Wei, J., & Cheng, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1251517 · Cited by 22
Li, X.-C., Wang, W., Jiang, C., Chen, Y.-L., Chen, J. F., Zhang, Z., Luo, S., Chen, R., Mo, P.-F., Zhong, M., et al. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.09.010 · Cited by 22
Causations between obesity, diabetes, lifestyle factors and the risk of low back pain
Liu, Y., Tang, G., & Li, J. (2023) · European Spine Journal · doi:10.1007/s00586-023-08069-6 · Cited by 25
Wu, J., Qin, T., Han, W., Zhang, C., Zhang, X., Huang, Z., Wu, Y., Xu, Y., Xu, K., & Ye, W. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.043 · Cited by 23
Chen, J., Gan, X., Su, S., Jiao, S., Gong, Z., Ziqiang, L., Wu, X., Jiang, J., Zhang, J., & Wan, J. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.02.052 · Cited by 21
Moal, B. L., Lepeltier, É., Rouleau, D., Visage, C. L., Benoît, J., Passirani, C., Guicheux, J., Fusellier, M., & Clouet, J. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121941 · Cited by 21
Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration
Huang, H., Liu, X., Wang, J., Suo, M., Zhang, J., Sun, T., Zhang, W., & Li, Z. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1215698 · Cited by 21
Karaduman, C., & Balcı, L. A. (2023) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2023.2263554 · Cited by 24
Liao, Z., Tong, B., Zhang, X., Zhang, W., Ke, W., Liang, H., Lei, M., Hua, W., Li, S., Song, Y., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1494 · Cited by 20
Qiu, Y., Wei, X., Tao, Y., Song, B., Wang, M., Yin, Z., Xie, M., Duan, A., Chen, Z., & Wang, Z. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1284594 · Cited by 22
Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration
Wang, X., Huang, Y., Yang, Y., Tian, X., Jin, Y., Jiang, W., He, H., Xu, Y. X., & Liu, Y. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101395 · Cited by 20
Wang, Y., Tan, L., Yang, Y., Duan, H., Liu, C., Zhao, J., Zhou, Y., Li, C., & Liu, M. (2025) · Nature Communications · doi:10.1038/s41467-025-66116-w · Cited by 20
Pan, H., Xi, Z., Yu, X., Sun, X., Wei, X., & Wang, K. (2021) · Journal of Pain Research · doi:10.2147/jpr.s340992 · Cited by 20
CRISPR-Cas9-mediated loss of function of β-catenin attenuates intervertebral disc degeneration
Fan, Y., Zhao, L., Lai, Y., Lü, K., & Huang, J. H. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.03.024 · Cited by 21
Du, Y., Li, J., Tang, X., Liu, Y., Bian, G., Shi, J., Zhang, Y., Zhao, B., Zhao, H., Sui, K., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.876157 · Cited by 20
Wang, Z., Zhang, P., Zhao, Y., Yu, F., Wang, S., Liu, K., Cheng, X., Shi, J., He, Q., Xia, Y., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.883118 · Cited by 21
Thomson, S., Williams, A. P., Vajramani, G., Sharma, M. L., Love‐Jones, S., Chawla, R., & Eldabe, S. S. (2023) · British Journal of Pain · doi:10.1177/20494637231181498 · Cited by 20
Hernández-Lucas, P., Leirós‐Rodríguez, R., Mota, J. A. P. S., & Soidán, J. L. G. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04061-1 · Cited by 21
Klapproth, C. P., Fischer, F. H., & Rose, M. (2023) · Health and Quality of Life Outcomes · doi:10.1186/s12955-023-02188-w · Cited by 21
Hu, Y., Yang, R., Liu, S., Song, Z., & Wang, H. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s448807 · Cited by 22
d’Errico, A., Falkstedt, D., Almroth, M., Badarin, K., Hemmingsson, T., & Kjellberg, K. (2022) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-022-01862-8 · Cited by 19
Tamagawa, S., Sakai, D., Schol, J., Sako, K., Nakamura, Y., Matsushita, E., Warita, T., Soma, H., Nojiri, H., Sato, M., et al. (2022) · JOR Spine · doi:10.1002/jsp2.1223 · Cited by 19
Wang, Y.-H., Zhou, Y., Xie, Y., Fan, X., Liang, W.-Q., Wei, X., Zhao, M., Huo, Y.-X., Zhang, T., & Yin, Y. (2023) · Medicine · doi:10.1097/md.0000000000032622 · Cited by 19
Qin, T., Yan, J., Li, S., Lin, X., Wu, J., Huang, Z., Zhang, C., Zhang, Y., Deng, Z., Xiao, D., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110678 · Cited by 20
Wang, Z., Ma, J., Sun, Y., Jin, Z., Zheng, R., Li, Y., Yu, H., Ye, H., Wu, Y., Ge, X., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112717 · Cited by 19
Jia, J., Zhang, M., Cao, Z., Yang, Z., Hu, X., Lei, S., Zhang, Y., Leng, W., & Kang, X. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04999-z · Cited by 31
Wang, J., Zhang, Y., Huang, Y., Hao, Z., Shi, G., Guo, L., Chang, C., & Li, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101251 · Cited by 18
Gu, H., Li, Q., Liu, Z., Li, Y., Liu, K., Kong, X., Zhang, Y., Meng, Q., Song, K., Xie, Q., et al. (2024) · Advanced Science · doi:10.1002/advs.202411162 · Cited by 19
Li, Z., Cheng, P., Xi, H., Jiang, T., Zheng, X., Qiu, J., Gong, Y., Wu, X., Mi, S., Hong, Y., et al. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s481714 · Cited by 18
Zhu, D., Liang, H., Tong, B., Du, Z., Li, G., Zhang, W.-F., Wu, D., Zhou, X., Lei, J., Zhang, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61486-7 · Cited by 20
Wu, T., Wang, Y., Shen, B., Guo, K., Zhu, Z., Liang, Y., Zeng, J., & Wu, D. (2025) · Advanced Science · doi:10.1002/advs.202506150 · Cited by 20
Leach, M., Climstein, M., Fryer, G., Kumar, S., & Agnew, T. (2023) · Pain Practice · doi:10.1111/papr.13214 · Cited by 19
Zhang, J., Tian, Y., Li, Y., Wang, H., Yuan, L., Zeng, Y., & Li, W. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.02.006 · Cited by 18
Su, Z., Liu, Z., Wang, M., Li, S., Lin, L., Yuan, Z., Pang, S., Feng, Q., Chen, T., & Lü, H. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25303 · Cited by 18
Vitamin D/VDR in the pathogenesis of intervertebral disc degeneration: Does autophagy play a role?
Lan, T., Shen, Z., Hu, Z., & Yan, B. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112739 · Cited by 17
Wang, D., Gao, Q., Schaefer, I., Mörz, H., Hoheisel, U., Rohr, K., Greffrath, W., & Treede, R. (2022) · Pain · doi:10.1097/j.pain.0000000000002642 · Cited by 17
Epigenetic Factors Related to Low Back Pain: A Systematic Review of the Current Literature
Ruffilli, A., Neri, S., Manzetti, M., Barile, F., Viroli, G., Traversari, M., Assirelli, E., Vita, F., Geraci, G., & Faldini, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031854 · Cited by 18
Metadata
- Authors
- Knezevic, N. N., Candido, K. D., Vlaeyen, J. W. S., Van Zundert, J., & Cohen, S. P.
- Affiliations
- University of Illinois Chicago (US)
- Maastricht University (NL)
- Johns Hopkins University (US)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 398
- Issue
- 10294
- Pages
- 78-92
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4211136641
- Cited by
- 1,345
- References
- 145
- Citations by year
- 2026: 274 · 2025: 380 · 2024: 317 · 2023: 239 · 2022: 113 · 2021: 22
- FWCI
- 21.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Lancet (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion, public-domain)
- Lirias (submittedVersion, public-domain)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- low back pain, pain classification, biopsychosocial model, diagnostic imaging, diagnostic injection, epidural steroid injection, spinal cord stimulation, radiofrequency ablation, intervertebral disc degeneration, sacroiliac joint, facet joints, neuropathic pain, nociplastic pain, non-specific low back pain, pain prevention, interdisciplinary treatment, pharmacotherapy, physiotherapy, psychological intervention, spinal decompression, disc replacement, spinal fusion, treatment algorithm, comparative effectiveness
- MeSH terms
- Humans, Risk Factors, Low Back Pain
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