The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
mRNA-based therapeutics: looking beyond COVID-19 vaccines
Open accessAbstract
Recent advances in mRNA technology and its delivery have enabled mRNA-based therapeutics to enter a new era in medicine. The rapid, potent, and transient nature of mRNA-encoded proteins, without the need to enter the nucleus or the risk of genomic integration, makes them desirable tools for treatment of a range of diseases, from infectious diseases to cancer and monogenic disorders. The rapid pace and ease of mass-scale manufacturability of mRNA-based therapeutics supported the global response to the COVID-19 pandemic. Nonetheless, challenges remain with regards to mRNA stability, duration of expression, delivery efficiency, and targetability, to broaden the applicability of mRNA therapeutics beyond COVID-19 vaccines. By learning from the rapidly expanding preclinical and clinical studies, we can optimise the mRNA platform to meet the clinical needs of each disease. Here, we will summarise the recent advances in mRNA technology; its use in vaccines, immunotherapeutics, protein replacement therapy, and genomic editing; and its delivery to desired specific cell types and organs for development of a new generation of targeted mRNA-based therapeutics.
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Cites
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Cited by
Ye, L., Zhao, G., Ma, J., Gan, Q., Luo, N., Pan, D., Chen, C., Chen, X., & Ning, S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02769-3 · Cited by 10
HydraRNA: a hybrid architecture based full-length RNA language model
Li, G., Jiang, F., Zhu, J., Cui, H., Wang, Z., & Chen, W. (2025) · Genome Biology · doi:10.1186/s13059-025-03853-7 · Cited by 10
Metadata
- Authors
- Parhiz, H., Atochina-Vasserman, E. N., & Weissman, D.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 403
- Issue
- 10432
- Pages
- 1192-1204
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4392564463
- Cited by
- 279
- References
- 137
- FWCI
- 32.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Parhiz, H., Atochina-Vasserman, E. N., & Weissman, D. (2024). mRNA-based therapeutics: looking beyond COVID-19 vaccines. The Lancet. https://doi.org/10.1016/s0140-6736(23)02444-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
