The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
The scope of the antimicrobial resistance challenge
Open accessAbstract
Each year, an estimated 7·7 million deaths are attributed to bacterial infections, of which 4.95 million are associated with drug-resistant pathogens, and 1·27 million are caused by bacterial pathogens resistant to the antibiotics available. Access to effective antibiotics when indicated prolongs life, reduces disability, reduces health-care expenses, and enables access to other life-saving medical innovations. Antimicrobial resistance undoes these benefits and is a major barrier to attainment of the Sustainable Development Goals, including targets for newborn survival, progress on healthy ageing, and alleviation of poverty. Adverse consequences from antimicrobial resistance are seen across the human life course in both health-care-associated and community-associated infections, as well as in animals and the food chain. The small set of effective antibiotics has narrowed, especially in resource-poor settings, and people who are very young, very old, and severely ill are particularly susceptible to resistant infections. This paper, the first in a Series on the challenge of antimicrobial resistance, considers the global scope of the problem and how it should be measured. Robust and actionable data are needed to drive changes and inform effective interventions to contain resistance. Surveillance must cover all geographical regions, minimise biases towards hospital-derived data, and include non-human niches.
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Cites
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Murray, C. J. L., Ikuta, K. S., Sharara, F., Swetschinski, L., Robles Aguilar, G., Gray, A., Han, C., Bisignano, C., Rao, P., Wool, E., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02724-0 · Cited by 16,316
Self-citationMurray, C. J. L., Aravkin, A. Y., Zheng, P., Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30752-2 · Cited by 9,854
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Urinary tract infections: epidemiology, mechanisms of infection and treatment options
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Kumarasamy, K. K., Toleman, M. A., Walsh, T. R., Bagaria, J., Butt, F., Balakrishnan, R., Chaudhary, U., Doumith, M., Giske, C. G., Irfan, S., et al. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70143-2 · Cited by 2,922
Ikuta, K. S., Swetschinski, L. R., Robles Aguilar, G., Sharara, F., Mestrovic, T., Gray, A. P., Davis Weaver, N., Wool, E. E., Han, C., Gershberg Hayoon, A., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)02185-7 · Cited by 2,235
Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016
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Cited by
Lewnard, J. A., Charani, E., Gleason, A., Hsu, L. Y., Khan, W. A., Karkey, A., Chandler, C. I. R., Mashe, T., Khan, E. A., Bulabula, A. N. H., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00862-6 · Cited by 220
Self-citationLaxminarayan, R., Impalli, I., Rangarajan, R., Cohn, J., Ramjeet, K., Trainor, B. W., Strathdee, S., Sumpradit, N., Berman, D., Wertheim, H., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00878-x · Cited by 111
Self-citationBatheja, D., Goel, S., & Charani, E. (2025) · BMJ Global Health · doi:10.1136/bmjgh-2024-016711 · Cited by 31
Metadata
- Authors
- Okeke, I. N., de Kraker, M. E. A., Van Boeckel, T. P., Kumar, C. K., Schmitt, H., Gales, A. C., Bertagnolio, S., Sharland, M., & Laxminarayan, R.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 403
- Issue
- 10442
- Pages
- 2426-2438
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4398244712
- Cited by
- 474
- References
- 101
- FWCI
- 91.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Okeke, I. N., de Kraker, M. E. A., Van Boeckel, T. P., Kumar, C. K., Schmitt, H., Gales, A. C., Bertagnolio, S., Sharland, M., & Laxminarayan, R. (2024). The scope of the antimicrobial resistance challenge. The Lancet. https://doi.org/10.1016/s0140-6736(24)00876-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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