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LIPODYSTROPHY AND HEPATOMEGALY WITH DIABETES, LIPÆMIA, AND OTHER METABOLIC DISTURBANCES
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“The metabolic phenotype is characterized by extreme dyslipidemia, insulin resistance, and diabetes (4).”
From Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy (2005) · cites this paper as [4]
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Leptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247
Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13
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Garg, A. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00414-3 · Cited by 375
Generalized lipodystrophy, congenital and acquired (lipoatrophy)
Seip, M., & Trygstad, O. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14262.x · Cited by 293
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The Complement Abnormalities of Lipodystrophy
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Clinical Features and Metabolic Derangements in Acquired Generalized Lipodystrophy
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Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy
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Congenital Lipodystrophic Diabetes With Acanthosis Nigricans
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The metabolism of isolated fat cells
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“An analogy is proposed with various lipodystrophies, demonstrating metabolic abnormalities such as insulin resistance (45) and dyslipidemia (22, 34), considered to be “paradoxically” similar to abnormalities found in obesity or adipose tissue excess.”
BackgroundCardiomyopathy in Congenital and Acquired Generalized Lipodystrophy
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Prevalence of Mutations in AGPAT2 Among Human Lipodystrophies
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Congenital Generalized Lipodystrophy Accompanied by Cystic Angiomatosis
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Steatohepatitis associated with limb lipodystrophy
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The premature ageing syndromes.
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Lack of AKT in adipocytes causes severe lipodystrophy
Shearin, A. L., Monks, B. R., Seale, P., & Birnbaum, M. J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.006 · Cited by 76
Familial Partial Lipodystrophy: A Monogenic Form of the Insulin Resistance Syndrome
Hegele, R. A. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3092 · Cited by 70
Radiological features in generalized lipodystrophy
Westvik, J. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14265.x · Cited by 68
Dunnigan-Kobberling syndrome: an autosomal dominant form of partial lipodystrophy
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The physiological role of brown adipose tissue1
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Fatty acid patterns in human adipose tissue
Hirsch, J. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050117 · Cited by 76
Nail changes associated with diabetes mellitus
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Some physiological and clinical implications of lipid mobilization from adipose tissue 1
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PPARγ: A Critical Determinant of Body Fat Distribution in Humans and Mice
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Serum Lipids and Their Value in Diagnosis
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Inherited disorders of pigmentation
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Autonomic nervous system and adipose tissue
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Hormonal control of adipose tissue metabolism, with special reference to the effects of insulin
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Obesity: an evolutionary context
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Comparative anatomy of adipose tissue1
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Association of Partial Lipodystrophy and Sjögren's Syndrome
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Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy
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The fine structure of adipose tissues
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Sicca Syndrome and Total Lipodystrophy
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Relative importance of different tissues in the synthesis of fatty acids
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Comparative physiology of adipose tissue in different sites and in different species
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Lipoatrophy, Lipodystrophy, and Insulin Resistance
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Adipose tissue in migratory birds
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The clearing factor lipase activity of adipose tissue
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Leptin treatment has vasculo-protective effects in lipodystrophic mice
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A multicenter validation of an active contour-based left ventricular analysis technique
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“Generalized lipodystrophy, first described by Lawrence in 1946, occurs less frequently, and involves the complete absence of subcutaneous adipose tissue (3).”
BackgroundPerfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat body
Scow, R. O. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050145 · Cited by 22
Morphology of adipose tissue: a microscopic anatomy of fat
Sheldon, H. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050113 · Cited by 21
Aslam, A. M., Savage, D. B., & Coulson, I. H. (2013) · International Journal of Dermatology · doi:10.1111/ijd.12185 · Cited by 19
Insulin Resistance and Acanthosis Nigricans
Pulini, M., Raff, S. B., Chase, R. M., & GORDON, E. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-85-6-749 · Cited by 18
Winegrad, A. I. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050132 · Cited by 17
Vaughan, M. M., & Steinberg, D. H. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050124 · Cited by 19
Effects of aging on the composition and metabolism of adipose tissue in the rat
Gellhorn, A., & Benjamin, W. B. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050141 · Cited by 19
Metadata
- Authors
- Lawrence, R. D.
- Corresponding author
- Lawrence, R.D.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1946-05
- Volume
- 247
- Issue
- 6403
- Pages
- 724-731
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1994670777
- Cited by
- 287
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2022: 3 · 2021: 5 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- lipodystrophy, hepatomegaly, diabetes mellitus, lipemia, metabolic disorders, hepatic steatosis
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