NEONATAL DIAGNOSIS OF FAMILIAL TYPE-II HYPERLIPOPROTEINÆMIA

Kwiterovich, PeterO.; Levy, RobertI.; Fredrickson, DonaldS.

doi:10.1016/s0140-6736(73)90194-3

Cited by 155Lipoproteins and Cardiovascular HealthLipid metabolism and disordersMetabolism and Genetic Disorders

NEONATAL DIAGNOSIS OF FAMILIAL TYPE-II HYPERLIPOPROTEINÆMIA

Kwiterovich, PeterO., Levy, RobertI., Fredrickson, DonaldS.·1973·The Lancet

DOI 10.1016/s0140-6736(73)90194-3

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Plasma low-density lipoprotein cholesterol concentration in monkeys and newborn humans are typically lower than 60 mg/dL, and LDL-cholesterol levels higher than 100 mg/dL are common only in people consuming Western diets rich in saturated fat from animal origin.
“Plasma low-density lipoprotein (LDL) cholesterol concentration in monkeys and newborn humans are typically lower than 60 mg/dL, and LDL-cholesterol levels higher than 100 mg/dL are common only in people consuming Western diets rich in saturated fat from animal origin (32).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [32]

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“Plasma low-density lipoprotein (LDL) cholesterol concentration in monkeys and newborn humans are typically lower than 60 mg/dL, and LDL-cholesterol levels higher than 100 mg/dL are common only in people consuming Western diets rich in saturated fat from animal origin (32).”
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Background
Familial Hypercholesterolemia (One Form of Familial Type II Hyperlipoproteinemia) A STUDY OF ITS BIOCHEMICAL, GENETIC, AND CLINICAL PRESENTATION IN CHILDHOOD
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“Height SDS* 0.2 (1.1) 0.2 (0.9) �0.01 (0.38) �0.01 (0.46) .87 BMI* 20 ( 3 ) 20 (4) 1.3 (1.6) 1.2 (1.3) .58”
Influential
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“Ethnicity* White 28 (80%) 15 (79%) Nonwhite 7 (20%) 4 (21%) Age, y 15 (2) 15 (2) Range† 11–18 11–18 Height, cm 164 (7) 163 (5) Weight, kg 61 (11) 58 (8) BMI, kg/m2 23 (4) 22 (3) Systolic BP, mm Hg 109 (1) 110 (11) Diastolic BP, mm Hg 67 (9) 66 (8) Heart rate, beats/min 72 (12) 71 (11) ALT, mIU/mL‡ 8 (3) 8 (4) AST, mIU…”
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Background
Special Supplemental Nutrition Program For Women, Infants, and Children
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“The further differentiation of cholesterol by ultracentrifugation showed a low HDL-fraction of 19 mg/dl (normal 24-57) [ 12 ] and a high LDL-fraction of 159 mg/dl (normal 18-46) [12] and VLDL-fraction of 45 rng/dl (normal 0-18) [12].”
BackgroundInfluential
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Authors: Kwiterovich, P., Levy, R., & Fredrickson, D.
Affiliations: National Institutes of Health (US)
Venue: The Lancet
Publisher: Elsevier BV
Published: 1973-01
Volume: 301
Issue: 7795
Pages: 118-122
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(73)90194-3
OpenAlex: W1990139485
Cited by: 154
References: 20
Citations by year: 2026: 1 · 2024: 3 · 2023: 2 · 2020: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 2
FWCI: 25.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords: familial hypercholesterolemia, type II hyperlipoproteinemia, neonatal diagnosis, umbilical cord blood, LDL cholesterol, hyperbetalipoproteinemia, family screening
MeSH terms: Child, Preschool, Cholesterol, Diet Therapy, Electrophoresis, Paper, Follow-Up Studies, Humans, Hyperlipidemias, Infant, Infant, Newborn, Infant, Newborn, Diseases, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Pedigree, Ultracentrifugation, Umbilical Arteries, Umbilical Veins

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NEONATAL DIAGNOSIS OF FAMILIAL TYPE-II HYPERLIPOPROTEINÆMIA

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