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Cited by 2,621Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

Miller, G.J, Miller, N.E·1975·The Lancet
DOI 10.1016/s0140-6736(75)92376-4
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Abstract

The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins. This finding supports existing evidence that H.D.L. facilitates the uptake of cholesterol from peripheral tissues and its transport to the liver for catabolism and excretion. Plasma-H.D.L., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease (I.H.D.), namely hypercholesterolaemia, hypertriglyceridaimia, male sex, obesity, and diabetes mellitus, while subjects with existing clinical I.H.D. have lower levels of H.D.L. than healthy subjects within the same community. It is proposed that a reduction of plasma-H.D.L. concentration may accelerate the development of atherosclerosis, and hence I.H.D., by impairing the clearance of cholesterol from the arterial wall.

Overview

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Crossref · 10.1016/s0140-6736(75)92376-4

Cites

59 of 59 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 59 references

Research works printed but not linked: 13

  1. Miller, 1973, J. Lab. clin. Med., 82, 876
  2. Goodman, 1973, J. Lipid Res., 52, 2646
  3. Insull, 1968, J. Lab. clin. Med., 72, 885
  4. Schreibman, 1973, Clin. Res., 21, 638
  5. P. Clifton-Bligh, N.E. Miller, P.J. Nestel, Clin. Sci. ((in the press)).
  6. Nikkilä, 1953, Scand. J. clin. Lab. Invest., 5
  7. Fredrickson, 1968, J. clin. Invest., 47, 2446, 10.1172/JCI105927 · DOI
  8. N.E. Miller, P.J. Nestel, Eur. J. clin. Invest. ((in the press)).
  9. Kannel, 1962, Geriatrics, 17, 675
  10. Murphy, 1962, J. Lab. clin. Med., 60, 86
  11. Kudchodkar, 1972, Clin. Res., 20, 944
  12. Jones, 1970, J. Lab. clin. Med., 75, 953
  13. Bondjers, 1974, Proc. Eur. Soc. clin. Invest., 8, 123

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Metadata

Authors
Miller, G. J., & Miller, N. E.
Affiliations
  • University Hospital Llandough (GB)
  • Edinburgh Royal Infirmary (GB)
ORCID
Miller, G.J
Venue
The Lancet
Publisher
Elsevier BV
Published
1975-01
Volume
305
Issue
7897
Pages
16-19
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(75)92376-4
OpenAlex
W1994967652
Cited by
2,621
References
59
Citations by year
2026: 5 · 2025: 11 · 2024: 9 · 2023: 7 · 2022: 15 · 2021: 17 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 29 · 2015: 29 · 2014: 22 · 2013: 32 · 2012: 26
FWCI
157.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
high-density lipoprotein, ischemic heart disease, atherosclerosis, cholesterol metabolism, hypercholesterolemia, hypertriglyceridemia, obesity, diabetes mellitus, sex differences, cardiovascular risk factors
MeSH terms
Arteries, Arteriosclerosis, Cholesterol, Coronary Disease, Denmark, Inuit, Female, Finland, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Liver, Male, Middle Aged, Sex Factors, Sweden, Triglycerides, United States

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