Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders
Abstract
HyperlipoproteinemiaDefinitionsUp to this point we have concentrated on laying the support for 2 generalizations. The first is that, with the exception of free fatty acid concentrations, which have no lipoprotein equivalents, all abnormalities in plasma lipid concentrations or dyslipidemia can be translated into dyslipoproteinemia. The second is that the shift of emphasis to lipoproteins offers distinct advantages in the recognition and management of such disorders. We have already discussed the relatively few cases in which hypolipoproteinemia is a clinical problem, and the remainder of the review will be devoted to hyperlipoproteinemia.Hyperlipoproteinemia (hyperlipidemia) falls into 2 . . .
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APOE2 homozygosity can lead to Hyperlipoproteinemia type III (HLP), characterized by mixed hypercholesterolemia and hypertriglyceridemia.
“The critical role of APOE in lipid metabolism is underscored by evidence showing that APOE2 homozygosity can lead to Hyperlipoproteinemia type III (HLP), characterized by mixed hypercholesterolemia and hypertriglyceridemia [35–39].”
The serum of APOE2hAβ rats exhibited a turbid appearance reminiscent of human cases of type III HLP.
“the serum of APOE2hAβ rats exhibited a turbid appearance (Fig. 7g) reminiscent of human cases of type III HLP [35]”
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- Authors
- Fredrickson, D. S., Levy, R. I., & Lees, R. S.
- Affiliations
- National Heart Institute (IN)
- Rockefeller University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1967-01-19
- Volume
- 276
- Issue
- 3
- Pages
- 148-156
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4236703259
- Cited by
- 526
- References
- 29
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- fat transport, lipoproteins, hyperlipoproteinemia, dyslipoproteinemia, dyslipidemia, free fatty acids, hyperlipidemia management
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