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PREVENTION OF SPINAL OSTEOPOROSIS IN OOPHORECTOMISED WOMEN
Abstract
100 women who had taken part in a prospective controlled trial of oestrogen therapy for prevention of post-oophorectomy bone loss were reviewed after a median follow-up period of nine years. A significant reduction in height occurred among the placebo-treated group, but not in the group treated with mestranol (mean 23 x 3 micrograms/day). The placebo-treated group had a higher spine score, lower central vertebral height, and larger wedge-angle than the oestrogen group. Within each group none of these spinal morphometric changes correlated with changes in mineral content of metacarpal or radial bones as measured by photon absorptiometry or X-ray densitometry, although both peripheral and central measurements showed highly significant differences between groups. Oestrogen treatment, therefore, prevents against central, as well as peripheral, bone loss, and reduces the incidence of vertebral compression.
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“Primary ovarian failure is associated with reduced BMD and increased risk of fractures (154-156), and estrogen replacement protects against fractures (154,157,158).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
In the citing paper
“Nonetheless, the literature on primary ovarian failure supports the beneficial effects of estrogen on bone.”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
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Love, R. R. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90007-q · Cited by 16
Spector, T. D., Edwards, A., & Thompson, P. W. (1992) · Annals of the Rheumatic Diseases · doi:10.1136/ard.51.11.1252 · Cited by 16
5 Why do oestrogens prevent bone loss?
Lindsay, R. S. (1991) · Baillière s Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(05)80291-3 · Cited by 16
Self-citation
Metadata
- Authors
- Lindsay, R., Hart, D. M., Forrest, C., & Baird, C.
- Affiliations
- Helen Hayes Hospital (US)
- Western Infirmary (GB)
- ORCID
- Lindsay, R.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 316
- Issue
- 8205
- Pages
- 1151-1154
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2004236425
- Cited by
- 706
- References
- 16
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 29.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- spinal osteoporosis, oophorectomy, estrogen therapy, bone loss prevention, vertebral compression, vertebral body height, wedge angle, bone mineral density, metacarpal bones, radial bone, postmenopausal women
- MeSH terms
- Body Height, Body Weight, Castration, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Mestranol, Metacarpus, Osteoporosis, Radiography, Spinal Diseases, Spine
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