The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
PREVENTION OF SPINAL OSTEOPOROSIS IN OOPHORECTOMISED WOMEN
Abstract
100 women who had taken part in a prospective controlled trial of oestrogen therapy for prevention of post-oophorectomy bone loss were reviewed after a median follow-up period of nine years. A significant reduction in height occurred among the placebo-treated group, but not in the group treated with mestranol (mean 23 x 3 micrograms/day). The placebo-treated group had a higher spine score, lower central vertebral height, and larger wedge-angle than the oestrogen group. Within each group none of these spinal morphometric changes correlated with changes in mineral content of metacarpal or radial bones as measured by photon absorptiometry or X-ray densitometry, although both peripheral and central measurements showed highly significant differences between groups. Oestrogen treatment, therefore, prevents against central, as well as peripheral, bone loss, and reduces the incidence of vertebral compression.
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“Primary ovarian failure is associated with reduced BMD and increased risk of fractures (154-156), and estrogen replacement protects against fractures (154,157,158).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
In the citing paper
“Nonetheless, the literature on primary ovarian failure supports the beneficial effects of estrogen on bone.”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
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Cites
LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ŒSTROGEN
Lindsay, R., Aitken, J. M., Anderson, L., Hart, D., Macdonald, E., & Clarke, A. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92217-0 · Cited by 875
Self-citationEffect of Estrogens and Calcium Carbonate on Bone Loss in Postmenopausal Women
Recker, R. R., Saville, P. D., & Heaney, R. P. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-649 · Cited by 563
HUTCHINSON, T. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90640-8 · Cited by 452
Prospective trial of oestrogen and calcium in postmenopausal women.
Horsman, A., Gallagher, J. C., Simpson, M., & Nordin, B. E. C. (1977) · BMJ · doi:10.1136/bmj.2.6090.789 · Cited by 374
BONE RESPONSE TO TERMINATION OF ŒSTROGEN TREATMENT
Lindsay, R., MacLean, A., Kraszewski, A., Hart, D. M., Clark, A. C., & Garwood, J. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92402-9 · Cited by 324
Self-citationTreatment of spinal osteoporosis in postmenopausal women.
Nordin, B. E. C., Horsman, A., Crilly, R. G., Marshall, D. H., & Simpson, M. (1980) · BMJ · doi:10.1136/bmj.280.6212.451 · Cited by 198
Comparative Effects of Oestrogen and a Progestogen on Bone Loss in Postmenopausal Women
Lindsay, R., Hart, D. M., Purdie, D. W., Ferguson, M. M., Clark, A. S., & Kraszewski, A. (1978) · Clinical Science · doi:10.1042/cs0540193 · Cited by 185
Self-citationHealing trabecular microfractures in the bodies of lumbar vertebrae.
Vernon-Roberts, B., & Pirie, C. J. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.406 · Cited by 183
SKELETAL UPTAKE OF DIPHOSPHONATE
Fogelman, I., COHEN, H. N., Bessent, R. G., Hart, D. M., & Lindsay, R. S. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92707-5 · Cited by 68
Self-citation5 Population Similarities in the Onset and Rate of Adult Endosteal Bone Loss
Garn, S. M., Rohmann, C. G., Wagner, B., Davila, G. H., & Ascoli, W. (1969) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196907000-00006 · Cited by 66
Research works printed but not linked: 2
- Hutchinson, 1979, Postmenopausal oestrogens protect against fractures of hip and distal radius, Lancet, ii, 706
- Gordan, 1973, Antifracture efficacy of long-term oestrogens for osteoporosis, Trans Ass Am Physicians, 86, 326
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Items 601–700 of 703
Osteoporosis—an opportunity to prevent being missed
Woolf, A. D. (1991) · Postgraduate Medical Journal · doi:10.1136/pgmj.67.789.601 · Cited by 1
Regional and total skeletal measurements in the early postmenopause
Stevenson, J., Banks, L., & Spinks, T. (1988) · Maturitas · doi:10.1016/0378-5122(88)90143-0 · Cited by 1
Bone turnover and trabecular plate survival after artificial menopause
REEVE, J. (1988) · Maturitas · doi:10.1016/0378-5122(88)90163-6 · Cited by 1
Nursing Management of the Woman with Osteoporosis
Handy, L. (1985) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.1985.tb02213.x · Cited by 1
Melis, G. B., Gambacciani, M., Spinetti, A., & FIORETTI, P. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb30372.x · Cited by 1
Stephenson, J., & Fuller, J. (1991) · BMJ · doi:10.1136/bmj.303.6815.1479 · Cited by 1
Bone turnover and trabecular plate survival after artificial menopause
Boo-Chai, K., & REEVE, J. (1988) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198808000-00104 · Cited by 1
The treatment of early ovarian failure
Cust, M. P. (1991) · Current Obstetrics and Gynaecology · doi:10.1016/0957-5847(91)90021-o · Cited by 1
ADFR therapy in the prevention of bone loss after menopause
Cano, R. P., Moruno, R., Montoya-García, M.-J., Vázquez, M. A., Galán, F., & Garrido, M. (1989) · Clinical Rheumatology · doi:10.1007/bf02207235 · Cited by 1
Non-invasive methods for quantitating bone loss of aging
Johnston, C. C., & Slemenda, C. W. (1990) · Experimental Gerontology · doi:10.1016/0531-5565(90)90065-a · Cited by 1
Anti-fracture efficacy of hormone replacement therapy
Reid, I. R. (2001) · BoneKEy-Osteovision · doi:10.1138/2001035 · Cited by 1
Ralston, S. H., & Grant, S. F. A. (1995) · Scottish Medical Journal · doi:10.1177/003693309504000101 · Cited by 1
AGE-RELATED CHANGES IN ELDERLY INDIVIDUALS
Espino, D. V., & Doty, S. (1993) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/s0891-8422(23)00580-3 · Cited by 1
Controversies in the use of hormone replacement therapy
GANGAR, K. F., Cust, M., & Whitehead, M. I. (1990) · Elsevier eBooks · doi:10.1016/b978-0-7236-0898-1.50019-8 · Cited by 1
Medical Oncologists and Risk Management in Breast Cancer
Hayes, D. F. (1994) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30540-4 · Cited by 1
Gallacher, S. (1993) · Enlighten: Theses (The University of Glasgow) · Cited by 1
New Trends in the Treatment of Osteoporosis
Barbagallo, M., Dominguez, L. J., Sangiorgi, G. B., & Passeri, M. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1483-5_29 · Cited by 1
Avis, N. E., Crawford, S. L., & Johannes, C. B. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0689-8_19 · Cited by 1
Notelovitz, M. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-715-4_11 · Cited by 1
Taxation of alcoholic beverages
(2020) · Consumption tax trends · doi:10.1787/49ed6b4f-en · Cited by 1
Estrogen-dependent Bone Loss and Osteoporosis
Lindsay, R. S., & Cosman, F. (2003) · doi:10.1007/978-1-4757-4561-0_9 · Cited by 1
Self-citationOsteoporosis in a 58-Year-Old Woman
Jackson, R. D. (1989) · Springer eBooks · doi:10.1007/978-1-4615-6716-5_16
The Anabolic Action of Estrogen on Rat Bone
Chambers, T. J., Chow, J. W. M., Lean, J. M., & Tobias, J. H. (1994) · Springer eBooks · doi:10.1007/978-3-662-03043-1_2
Clinical Aspects of Osteoporosis
Kuhlencordt, F. (1987) · Springer eBooks · doi:10.1007/978-3-642-73346-8_1
P RODUCTION AND A CTIONS OF E STROGENS
Ruber, C. H. J. G., Schugguel, W. A. T., Chneeberger, C. H. S., Ohannes, J., & Uber, C. H. (2002)
The Osteogenic Effects of 12 Weeks of Oral Supplementation of Androstenedione in Middle-Aged Men.
Wills, T. (2003) · Digital Commons - East Tennessee State University (East Tennessee State University)
Densidad mineral ósea en el cáncer diferenciado de tiroides en tratamiento con levo-tiroxina
Álvarez, M. B. L. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Bone mineral mass and bone turnover parameters in osteoporosis
Erdtsieck, R. J. (1996) · RePub (Erasmus University Rotterdam)
Salomon, B. (2001) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2001.01228.x
Management: Established Osteoporosis in Organ Transplant Recipients
Reid, I. R. (2005) · Elsevier eBooks · doi:10.1016/b978-012183502-6/50025-0
View of a Clinician: Sex Steroids and Osteoporosis
Compston, J. E. (1994) · Springer eBooks · doi:10.1007/978-3-662-03043-1_1
The Role of Hormone Replacement Therapy in the Prevention and Treatment of Osteoporosis
Ellerington, M. C., Whitehead, M. I., & Stevenson, J. C. (1994) · CPOBGYN. Clinical perspectives in obstetrics and gynecology · doi:10.1007/978-1-4612-4330-4_16
Berning, B. (2001)
Avery, J. G. (1991) · BMJ · doi:10.1136/bmj.303.6807.926-a
Long-term sequelae of hormone replacement therapy: benefits and risks
Barlow, D. H. (1997) · Current Obstetrics and Gynaecology · doi:10.1016/s0957-5847(97)80034-0
NAGATA, H., Nozaki, M., & Nakano, H. (2003) · Osteoporosis International · doi:10.1007/s00198-003-1447-7
Late prevention of hip fractures with hormone replacement therapy
Stevenson, J. C. (1996) · Osteoporosis International · doi:10.1007/bf01623769
The prevention of bone loss in women
Purdie, D. W. (1991) · Current Obstetrics and Gynaecology · doi:10.1016/0957-5847(91)90020-x
Les thérapeutiques médicamenteuses préventives de l'ostéoporose postménopausique
Chaouat, D., & Tsouderos, Y. (1993) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(05)81148-8
Dokou, S., Satou, Y., & Soeda, Y. (1994) · Journal of Bone and Mineral Metabolism · doi:10.1007/bf02383414
Fracturas vertebrales tras tratamiento hormonal en la menopausia: 20 años de seguimiento
Perelló, M. F., Peguero, A., Ros, C., Martínez‐Serrano, M. J., & Castelo‐Branco, C. (2013) · Progresos de Obstetricia y Ginecología · doi:10.1016/j.pog.2013.04.007
Postmenopausal Estrogen/Progestin Intervention Trial ( PEPI )
Langer, R. D. (2008) · Wiley Encyclopedia of Clinical Trials · doi:10.1002/9780471462422.eoct399
Liu, J. (2013) · UvA-DARE (University of Amsterdam)
Measurement of bone mineral mass in clinical perspective
van Berkum, F. (1991)
New thoughts about estrogen therapy from the Women’s Health Initiative
Ko, M. G. (2008) · Current Osteoporosis Reports · doi:10.1007/s11914-008-0019-3
Raloxifene and Breast Cancer: The Influence of Estradiol
Ji, W., Kelsey, J. L., & Nevitt, M. C. (2002)
revisã o Osteoporose Pós-Menopausa: Opções Terapêutica s
Augusto, L. M., & Russ, T. (2001)
Hormone Replacement Therapy - the Evidence so far
Chatterjee, A. (2004)
T REATMENT OF P OSTMENOPAUSAL O STEOPOROSIS
Astell, R. I. E. (1998)
Prolactin, hormone replacement therapy, and breast cancer
Notelovitz, M. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)91023-2
Interactions Between Calcium Intake and Antiresorptive Therapy in Osteoporosis
Nieves, J. W., Komar, L., Cosman, F., & Lindsay, R. S. (1998) · Springer eBooks · doi:10.1007/978-1-4612-2228-6_34
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Okano, H. (1994) · Kitakantou igaku/Kitakantō Igaku · doi:10.2974/kmj1951.44.135
Estrogen Therapy for Osteoporosis: Is It Effective?
Barzel, U. S. (1990) · Hospital Practice · doi:10.1080/21548331.1990.11703972
Endocrine interventions in women with BRCA1/2 mutations
Schüler‐Toprak, S., Seitz, S., & Ortmann, O. (2016) · Der Gynäkologe · doi:10.1007/s00129-016-3864-7
Osteoporosis: latest innovation in therapy.
Taechakraichana, N., & Witoonpanich, P. (2004) · PubMed
Bone Disease in Chronic Cholestatic Liver Disease
Dobnig, H., & Fahrleitner, A. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9034-1_22
MR Imaging of Connective Tissue Degeneration
Hickey, D. S., Aspden, R. M., Sivewright, G. J., & Prendergast, D. J. (1990) · doi:10.1007/978-1-349-09865-1_9
The Pharmacology of Estrogens in Osteoporosis
Lindsay, R., & Cosman, F. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00011-2
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Lane, J. M., & Cornell, C. N. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-2220-6.10018-0
Novel Collagen Markers for Early Detection of Bone Metastases in Breast and Prostate Cancer Patients
Leeming, D. J., Barkholt, V., Hägglund, P., & Jacobsen, S. (2010) · Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)
Costes de la terapia hormonal sustitutiva en la menopausia
Gil‐Antuñano, S. P. (2017) · Revista de medicina de la Universidad de Navarra · doi:10.15581/021.9350
Marcus, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391884-0.00045-7
Castañeda, G. B., Torres, E. P., & Mejía, J. C. R. (1994) · Revista Colombiana de Obstetricia y Ginecología · doi:10.18597/rcog.1785
Drug delivery to osteoclast receptor targets
Kalvapalle, R. (2009) · doi:10.7939/r3ts7w
Lachelin, G. C. L. (1991) · Elsevier eBooks · doi:10.1016/b978-0-7506-1171-8.50018-0
Mechanisms of Estrogen Action in Bone
Pacifici, R. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50141-4
Prophylactic oophorectomy at hysterectomy for benign pathology
Vergote, I. B., & Buytaert, P. (1984) · Springer eBooks · doi:10.1007/978-94-009-5608-7_26
Pak, C. Y. C. (1983) · CPOBGYN. Clinical perspectives in obstetrics and gynecology · doi:10.1007/978-1-4612-5525-3_4
Therapeutic Approaches and Mechanisms of Drug Action
Bernecker, P. M. (2003) · Medical radiology · doi:10.1007/978-3-662-05235-8_3
Belchetz, P. E. (1993) · Reviews in Clinical Gerontology · doi:10.1017/s095925980000335x
(1997) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1997.tb138955.x
The aging spine: new technologies and therapeutics for the osteoporotic spine
Lane, J. M., Gardner, M. J., Lin, J. T., van der Meulen, M. C. H., & Myers, E. R. (2005) · Springer eBooks · doi:10.1007/3-540-27376-x_9
Postmenopausal Estrogen/Progestin Interventions Trial (PEPI)
Langer, R. D. (2014) · doi:10.1002/9781118596005.ch63
Reiss, E. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5356-0_18
Kleerekoper, M., & Verma, A. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-157-2_13
When Your Patient Asks You About Osteoporosis
(1987) · American Pharmacy · doi:10.1016/s0160-3450(16)33268-8
Dixon, A. S. J. (1991) · BMJ · doi:10.1136/bmj.303.6807.926-b
Mason, R. S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737719558.793580263
(2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1988.tb05398.x
Oladipo, A., & Stevenson, J. (2000) · Springer eBooks · doi:10.1007/978-1-4471-3825-9_29
Is bone density screening worth while?
(1992) · The Lancet · doi:10.1016/0140-6736(92)90228-u
Brenner, P. F. (1982) · PubMed Central
Hatasaka, H. H., & Speroff, L. (1991) · CPOBGYN. Clinical perspectives in obstetrics and gynecology · doi:10.1007/978-1-4613-9086-2_22
Sağlık Bilimleri Araştırmaları: Temel Tıp-III
Çiçek, H., Cengiz, C., Ekim, H., Ekim, H., Korkmaz, O., Kurt, A. A., Ibrahim, B., & Akkitap, M. P. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248
Acil Tıpta Liderlik: Türler, Modeller, Yaklaşımlar
Cengiz, C. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248.c1156
Diyabetin Önlenmesinde ve Tedavisinde Akdeniz Diyetinin Rolü
Ekim, M., & Ekim, H. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248.c1160
Korkmaz, O. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248.c1158
Kurt, A. A., & Ibrahim, B. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248.c1159
Kserostomi ile Yaşamak: Sorunlar ve Olası Çözümler
Akkitap, M. P. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248.c1161
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Ekim, M., & Ekim, H. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub248.c1157
McGlacken-Byrne, S. M., Gunn, H. M., & Simpson, H. (2023) · Endocrinology · doi:10.1007/978-3-030-18901-3_29-1
Osteoporosis in Relation to Menopause
Choo, W. L., Loh, F. H., & Ng, S. C. (2002) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v31n1p30
Long-term Follow-up of Women on HRT
Hart, D. (1990) · Springer eBooks · doi:10.1007/978-1-4471-1799-5_20
Self-citationSchneider, H. P. G. (1990) · Steinkopff eBooks · doi:10.1007/978-3-642-72452-7_8
Metadata
- Authors
- Lindsay, R., Hart, D. M., Forrest, C., & Baird, C.
- Affiliations
- Helen Hayes Hospital (US)
- Western Infirmary (GB)
- ORCID
- Lindsay, R.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 316
- Issue
- 8205
- Pages
- 1151-1154
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2004236425
- Cited by
- 706
- References
- 16
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 29.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- spinal osteoporosis, oophorectomy, estrogen therapy, bone loss prevention, vertebral compression, vertebral body height, wedge angle, bone mineral density, metacarpal bones, radial bone, postmenopausal women
- MeSH terms
- Body Height, Body Weight, Castration, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Mestranol, Metacarpus, Osteoporosis, Radiography, Spinal Diseases, Spine
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