ABNORMALITIES IN CENTRAL MOTOR PATHWAY CONDUCTION IN MULTIPLE SCLEROSIS
Abstract
The technique of scalp stimulation of the motor cortex was used to demonstrate abnormalities in the corticomotoneuron pathway in multiple sclerosis. Unilateral or bilateral delays in corticomotoneuron conduction, dispersion of corticomotoneuron volleys, or both, were shown to occur in such patients. Changes may be seen even in patients with little clinical evidence of corticomotoneuron deficit.
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Frontal fasciculi are among the last fasciculi to structurally mature in the developing human brain, with myelination continuing through adolescence and into early adulthood.
“Second, these frontal fasciculi are among the last fasciculi to structurally mature in the developing human brain, with myelination thought to continue through adolescence and into early adulthood, [40][41][42][43]”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [43]
Cites
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THE EFFECTS OF EXPERIMENTAL DEMYELINATION ON CONDUCTION IN THE CENTRAL NERVOUS SYSTEM
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SCOPE OF A TECHNIQUE FOR ELECTRICAL STIMULATION OF HUMAN BRAIN, SPINAL CORD, AND MUSCLE
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Self-citationNeuropathology of Multiple Sclerosis
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[Neuropathology of multiple sclerosis].
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Activation of the human diaphragm from the motor cortex.
Gandevia, S. C., & Rothwell, J. C. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016445 · Cited by 251 · see citing works
Self-citationSchizophrenia, myelination, and delayed corollary discharges: a hypothesis
Whitford, T. J., Ford, J. M., Mathalon, D. H., Kubicki, M., & Shenton, M. E. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq105 · Cited by 140 · see citing works
- Authors
- Cowan, J. M. A., Dick, J. P. R., Day, B. L., Rothwell, J. C., Thompson, P. D., & Marsden, C. D.
- Affiliations
- King's College Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1984-08
- Volume
- 324
- Issue
- 8398
- Pages
- 304-307
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2159349677
- Cited by
- 151
- References
- 6
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2012: 1
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, motor cortex stimulation
- MeSH terms
- Adult, Cerebral Cortex, Electromyography, Evoked Potentials, Female, Humans, Male, Middle Aged, Motor Neurons, Multiple Sclerosis, Synaptic Transmission, Spinal Cord
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