EFFECT OF A GINKGOLIDE MIXTURE (BN 52063) IN ANTAGONISING SKIN AND PLATELET RESPONSES TO PLATELET ACTIVATING FACTOR IN MAN
Abstract
Antagonism of the effects of platelet activating factor (PAF) by the ginkgolide mixture BN 52063 was assessed in a double-blind, placebo-controlled, crossover study in 6 normal subjects. Weal and flare responses to 400 ng PAF, examined 2 h after ingestion of BN 52063 (80 mg, 120 mg) were inhibited in a dose-related manner. After 120 mg the flare area was reduced by a mean 62.4% (p less than 0.005) and the weal volume by a mean 60% (p less than 0.05). Both doses of BN 52063 significantly inhibited PAF-induced platelet aggregation in platelet-rich plasma (p less than 0.001). In vitro, BN 52063 inhibited PAF-induced but not ADP-induced platelet aggregation. Thus BN 52063 seems to be an antagonist of PAF in man.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An 80-year-old woman with Alzheimer's disease and depression became comatose after taking trazodone concomitantly with Ginkgo.
“an 80-year old woman with AD and also being managed for depression became comatose after taking trazodone (an antidepressant) concomitantly with Ginkgo [109]”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [109]
Cites
Cuss, F. M., Dixon, C. M. S., & Barnes, P. J. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92489-x · Cited by 463 · see citing works
Self-citationCV-3988 - A specific antagonist of platelet activating factor (PAF)
Terashita, Z., Tsushima, S., YOSHIOKA, Y., et al. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90049-8 · Cited by 336 · see citing works
Role of inflammation in the hyperreactivity of the airways in asthma.
Chung, K. F. (1986) · Thorax · doi:10.1136/thx.41.9.657 · Cited by 258 · see citing works
Self-citationKornecki, E., Ehrlich, Y. H., & Lenox, R. H. (1984) · Science · doi:10.1126/science.6150550 · Cited by 213 · see citing works
Braquet, P. G., Spinnewyn, B., Braquet, M., et al. (1985) · Blood & Vessel · doi:10.2491/jjsth1970.16.558 · Cited by 206 · see citing works
Farr, R. S., Cox, C. P., Wardlow, M. L., & Jorgensen, R. (1980) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(80)90044-6 · Cited by 203 · see citing works
Morley, J. E., Sanjar, S., & Page, C. P. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91567-8 · Cited by 193 · see citing works
Self-citationAssociation of Platelet-Activating Factor with Primary Acquired Cold Urticaria
Grandel, K. E., Farr, R. S., Wanderer, A. A., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508153130702 · Cited by 191 · see citing works
Shen, T. Y., Hwang, S. B., Chang, M. N., et al. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.672 · Cited by 155 · see citing works
ACCUMULATION OF EOSINOPHILS IN RESPONSE TO INTRACUTANEOUS PAF-ACETHER AND ALLERGENS IN MAN
Hénocq, E., & Vargaftig, B. B. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91683-1 · Cited by 149 · see citing works
Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin
ARCHER, C. B., Page, C. P., Paul, W. M., et al. (1984) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1984.tb07310.x · Cited by 130 · see citing works
Self-citationNunez, D., Chignard, M., Korth, R., et al. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90660-6 · Cited by 124 · see citing works
Role of Platelet-Activating Factor-Acether in Mediating Guinea Pig Anaphylaxis
Darius, H., Lefer, D. J., Smith, J. B., & Lefer, A. M. (1986) · Science · doi:10.1126/science.3082008 · Cited by 98 · see citing works
Braquet, P. G., Etienne, A., Touvay, C., et al. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92269-x · Cited by 90 · see citing works
Lipid mediators of inflammation and allergy.
O’Flaherty, J. T. (1982) · PubMed · Cited by 85 · see citing works
Bruynzeel, P. L. B., Koenderman, L., Kok, P. T. M., et al. (1986) · Pharmacological Research Communications · doi:10.1016/0031-6989(86)90039-1 · Cited by 78 · see citing works
CASALS‐STENZEL, J. (1987) · Immunopharmacology · doi:10.1016/0162-3109(87)90048-8 · Cited by 73 · see citing works
Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist
Guinot, P., Braquet, P. G., Duchier, J., et al. (1986) · Prostaglandins · doi:10.1016/0090-6980(86)90161-9 · Cited by 49 · see citing works
Self-citationStimulus amplification by PAF and LTB4 in human neutrophils
Baggiolini, M., & Dewald, B. (1986) · Pharmacological Research Communications · doi:10.1016/0031-6989(86)90038-x · Cited by 31 · see citing works
Coëffier, E., Borrel, M.-C., Lefort, J., et al. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90571-6 · Cited by 17 · see citing works
Deeming, K., Mazzoni, L., Morley, J. E., et al. (1985) · Prostaglandins · doi:10.1016/0090-6980(85)90050-4 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Spontaneous Hyphema Associated with Ingestion of<i>Ginkgo biloba</i>Extract
Rosenblatt, M., & Mindel, J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361518 · Cited by 341 · see citing works
Phytotherapy: A promising approach for the treatment of Alzheimer's disease
John, O. O., Amarachi, I. S., Chinazom, A. P., Adaeze, E., Kale, M. B., Umare, M. D., & Upaganlawar, A. B. (2022) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100030 · Cited by 69 · see citing works
- Authors
- Chung, K. F., Mccusker, M., Page, C. P., Dent, G., Guinot, P., & Barnes, P. J.
- Affiliations
- University of London (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 329
- Issue
- 8527
- Pages
- 248-251
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2015386735
- Cited by
- 289
- References
- 21
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 8
- FWCI
- 43.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
- Keywords
- ginkgolides, platelet-activating factor, PAF antagonists, skin reactions, platelet aggregation, platelet-rich plasma, ADP-induced aggregation, dose-response relationship
- MeSH terms
- Adult, Capsules, Clinical Trials as Topic, Double-Blind Method, Humans, Injections, Intradermal, Lactones, Plant Extracts, Platelet Activating Factor, Platelet Aggregation, Random Allocation, Skin, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
