Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis
Abstract
The aim of this study was to evaluate serum and peritoneal fluid (PF) glycodelin-A concentrations in women with ovarian endometriosis. Ninety-nine matched pairs of serum and PF samples were included in our study. The case group comprised 57 women with ovarian endometriosis and the control group 42 healthy women undergoing sterilization or patients with benign ovarian cysts. Glycodelin-A concentrations were measured using ELISA. Endometriosis patients had significantly higher serum and PF glycodelin-A concentrations compared to controls, and this increase was observed in both proliferative and secretory cycle phases. Glycodelin-A concentrations were more than 10-fold higher in PF than in serum and correlated with each other. Intensity and frequency of menstrual pain positively correlated with glycodelin-A concentrations. Sensitivity and specificity of glycodelin-A as a biomarker for ovarian endometriosis were 82.1% and 78.4% in serum, and 79.7% and 77.5% in PF, respectively. These results indicate that Glycodelin-A has a potential role as a biomarker to be used in combination with other, independent marker molecules.
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A different study found a significant increase in serum glycodelin A in women with endometrioma (n=57) compared with control women (n=42) and demonstrated potential use as a biomarker for ovarian endometriosis with sensitivity of 82.1% and specificity of 78.4%.
“A different study assessing glycodelin A found a significant increase in serum of women with endometrioma (n = 57) compared with control women undergoing sterilization or having benign ovarian cysts (n = 42) and demonstrated the potential use of glycodelin A as a biomarker for ovarian endometriosis with a sensitivity of 82.1% and a sensitivity of 78.4% [47].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [47]
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Update on biomarkers for the detection of endometriosis
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“CA-125 combinedwith interleukin-8 (IL8) and tumor necrosis factors-𝛼 (TNF-𝛼) in the secretory phase had a sensitivity of 89.7% and specificity of 71.1% in a study performed by Mihalyi and coworkers [36].”
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- Authors
- Kocbek, V., Vouk, K., Mueller, M. D., Rižner, T. L., & Bersinger, N. A.
- Affiliations
- University of Ljubljana (SI)
- University of Bern (CH)
- Corresponding author
- Rižner, Tea Lanišnik
- Bersinger, Nick A.
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2013-03-06
- Volume
- 29
- Issue
- 5
- Pages
- 455-459
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2056280262
- Cited by
- 47
- References
- 28
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 4
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Funders
- Javna Agencija za Raziskovalno Dejavnost RS
- Univerza v Ljubljani
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- glycodelin-A, endometrioma, peritoneal fluid, serum biomarkers, dysmenorrhea, sensitivity and specificity, menstrual cycle phases, benign ovarian cysts
- MeSH terms
- Glycodelin, Adult, Ascitic Fluid, Endometriosis, Female, Glycoproteins, Humans, Ovarian Diseases, Biomarkers, Case-Control Studies
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