Cited by 270Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

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PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

Goate, AlisonM., Owen, MichaelJ., James, LouiseA., Mullan, MichaelJ., Rossor, MartinN., Haynes, AndrewR., Farrall, Martin, Lai, LawrenceY.C., Roques, Penelope, Williamson, Robert, Hardy, JohnA.·1989·The Lancet

DOI 10.1016/s0140-6736(89)91725-x

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Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

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Authors: Goate, A., Owen, M., James, L., Mullan, M., Rossor, M., Haynes, A., Farrall, M., Lai, L. C., Roques, P., Williamson, R., & Hardy, J.
Affiliations: St Mary's Hospital (GB)
Venue: The Lancet
Publisher: Elsevier BV
Published: 1989-02
Volume: 333
Issue: 8634
Pages: 352-355
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(89)91725-x
OpenAlex: W2115363308
Cited by: 270
References: 20
Citations by year: 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 3 · 2015: 18 · 2014: 3 · 2013: 3 · 2012: 2
FWCI: 32.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: Alzheimer's disease, chromosome 21, genetic linkage, early-onset Alzheimer's disease, genetic susceptibility, familial Alzheimer's disease
MeSH terms: Adult, Alzheimer Disease, Chromosome Aberrations, Chromosome Mapping, Chromosomes, Human, Pair 21, Female, Humans, Genetic Linkage, Male, Middle Aged, Mutation, Recombination, Genetic, Polymorphism, Restriction Fragment Length, Blotting, Southern, Chromosome Disorders

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PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

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