Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

Yanisch-Perron, C., Vieira, J., & Messing, J. W. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 14,868 · see citing works

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 14,678 · see citing works

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Botstein, D., White, R. L., Skolnick, M. H., & Davis, R. W. (1980) · Europe PMC (PubMed Central) · Cited by 8,327 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.

Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works

Efficient isolation of genes by using antibody probes.

Young, R. A., & Davis, R. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.5.1194 · Cited by 2,036 · see citing works

Amyloid Deposits and Amyloidosis

Glenner, G. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006053022305 · Cited by 1,794 · see citing works

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693 · see citing works

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,333 · see citing works

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

George‐Hyslop, P. S., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L. E., Watkins, P. C., Myers, R. H., Feldman, R. G., Pollen, D. A., Drachman, D. A., et al. (1987) · Science · doi:10.1126/science.2880399 · Cited by 1,160 · see citing works

Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Ott, J. (1974) · PubMed · Cited by 1,028 · see citing works

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987 · see citing works

Senile dementia of the Alzheimer type

Terry, R. D., & Katzman, R. (1983) · Annals of Neurology · doi:10.1002/ana.410140502 · Cited by 831 · see citing works

Some morphometric aspects of the brain in senile dementia of the alzheimer type

Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801 · see citing works

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Neve, R. L., Harris, P. K. W., Kosik, K. S., Kurnit, D. M., & Donlon, T. A. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90033-1 · Cited by 565 · see citing works

Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes.

Vinters, H. V., & Gilbert, J. J. (1983) · Stroke · doi:10.1161/01.str.14.6.924 · Cited by 504 · see citing works

Dementia of the Alzheimer Type

Heston, L. L. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780350019001 · Cited by 450 · see citing works

Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects

ROTH, M., TOMLINSON, B. E., & BLESSED, G. (1966) · Nature · doi:10.1038/209109a0 · Cited by 298 · see citing works

A computer program for linkage analysis of general human pedigrees.

Ott, J. (1976) · PubMed · Cited by 297 · see citing works

Identification of prion amyloid filaments in scrapie-infected brain

DeArmond, S. J., McKinley, M. P., Barry, R. A., Braunfeld, M. B., McColloch, J. R., & Prusinert, S. B. (1985) · Cell · doi:10.1016/0092-8674(85)90076-5 · Cited by 294 · see citing works

The incidence of cerebral amyloid angiopathy in Alzheimer's disease

Mandybur, T. I. (1975) · Neurology · doi:10.1212/wnl.25.2.120 · Cited by 286 · see citing works

Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques

MERZ, P. A., Wı́sniewski, H. M., Somerville, R. A., Bobin, S. A., Masters, C. L., & Iqbal, K. (1983) · Acta Neuropathologica · doi:10.1007/bf00685355 · Cited by 171 · see citing works

Down's syndrome

Niebuhr, E. (1974) · Human Genetics · doi:10.1007/bf00278575 · Cited by 134 · see citing works

BrdU-33258 Hoechst analysis of DNA replication in human lymphocytes with supernumerary or structurally abnormal X chromosomes

Latt, S. A., Willard, H. F., & Gerald, P. S. (1976) · Chromosoma · doi:10.1007/bf00292912 · Cited by 124 · see citing works

Isolation of polymorphic DNA fragments from human chromosome 4

Gilliam, T. C., Healey, S. T., MacDonald, M. E., Stewan, G. D., Wasmuth, J. J., Tanzi, R. E., Roy, J. C., & Gusella, J. F. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.4.1445 · Cited by 100 · see citing works

Partial trisomy 21

Hagemeijer, A., & Smit, E. M. E. (1977) · Human Genetics · doi:10.1007/bf00295803 · Cited by 98 · see citing works

Senile Degenerative Brain Lesions and Dementia

Morimatsu, M., Hirai, S., Muramatsu, A., & Yoshikawa, M. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00425.x · Cited by 86 · see citing works

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

Keuren, M. L. V., Watkins, P. C., Drabkin, H., Jabs, E. W., Gusella, J. F., & Patterson, D. (1986) · PubMed · Cited by 84 · see citing works

Familial Down syndrome due to t(10;21) translocation: evidence that the Down phenotype is related to trisomy of a specific segment of chromosome 21.

Williams, J. D., Summitt, R. L., Martens, P. R., & Kimbrell, R. A. (1975) · Europe PMC (PubMed Central) · Cited by 78 · see citing works

Localisation of genetic markers and orientation of the linkage group on chromosome 19

Brook, J. D., Shaw, D. J., Meredith, L., Bruns, G. A. P., & Harper, P. S. (1984) · Human Genetics · doi:10.1007/bf00292584 · Cited by 68 · see citing works

Human lysosomal genes: Arylsulfatase A and ?-Galactosidase

Bruns, G. A. P., Mintz, B. J., Leary, A., Regina, V. M., & Gerald, P. S. (1979) · Biochemical Genetics · doi:10.1007/bf00504344 · Cited by 57 · see citing works

A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle

Neve, R. L., Selkoe, D. J., Kurnit, D. M., & Kosik, K. S. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90011-2 · Cited by 40 · see citing works

Isolation of polymorphic DNA segments from human chromosome 21

Watkins, P. C., Tanzi, R. E., Gibbons, K., Tricoli, J. V., Landes, G. M., Eddy, R. L., Shows, T. B., & Gusella, J. F. (1985) · Nucleic Acids Research · doi:10.1093/nar/13.17.6075 · Cited by 39 · see citing works

Human chromosome 21-encoded cDNA clones

Neve, R. L., Stewart, G. D., Newcomb, P., Keuren, M. L. V., Patterson, D., Drabkin, H. A., & Kurnit, D. M. (1986) · Gene · doi:10.1016/0378-1119(86)90372-0 · Cited by 38 · see citing works

Partial trisomies of chromosome 21 in man. Two new observations due to translocations 19;21 and 4;21

Pfeiffer, R. A., Kessel, E., & Soer, K. (1977) · Clinical Genetics · doi:10.1111/j.1399-0004.1977.tb01301.x · Cited by 37 · see citing works

Low levels of calpain activity in Chiroptera brain: Implications for mechanisms of aging

Baudry, M., Dubrin, R., Beasley, L. J., Leon, M., & LYNCH, G. S. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90004-7 · Cited by 30 · see citing works

Familial t (4;21)(q2.4;q2.2) leading to unbalanced offspring with partial duplication of 4q and of 21q without manifestations of the down syndrome

Kitsiou‐Tzeli, S., Hallett, J. J., Atkins, L., Latt, S. A., Holmes, L. B., Opitz, J. M., & Reynolds, J. F. (1984) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320180419 · Cited by 12 · see citing works

Abstracts of workshop presentations (Part 12 of 13)

Willard, H. F., Skolnick, M. H., Pearson, P. L., Mandel, J.-L., Willard, H. F., Skolnick, M. H., Pearson, P. L., Mandel, J.-L., Willard, H. F., Skolnick, M. H., et al. (2010) · Cytogenetics and Cell Genetics · doi:10.1159/000316955 · Cited by 12 · see citing works

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works

Mild cognitive impairment

Gauthier, S. G., Reisberg, ‌., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K., & Sekiya, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2766 · Cited by 3,589 · see citing works

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771 · see citing works

Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)

Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729 · see citing works

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471 · see citing works

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Uéda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J. D. M., Ihara, Y., & Saitoh, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11282 · Cited by 1,469 · see citing works

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., et al. (1992) · Science · doi:10.1126/science.1439760 · Cited by 1,447 · see citing works

Alzheimer’s Disease: The Challenge of the Second Century

Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403 · see citing works

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I. M., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1990) · Science · doi:10.1126/science.2111584 · Cited by 1,380 · see citing works

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,333 · see citing works

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

Weidemann, A., König, G., Bunke, D., Fischer, P. Q., Salbaum, J. M., Masters, C. L., & Beyreuther, K. T. (1989) · Cell · doi:10.1016/0092-8674(89)90177-3 · Cited by 1,233 · see citing works

Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease

Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

George‐Hyslop, P. S., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L. E., Watkins, P. C., Myers, R. H., Feldman, R. G., Pollen, D. A., Drachman, D. A., et al. (1987) · Science · doi:10.1126/science.2880399 · Cited by 1,160 · see citing works

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Murrell, J. R., Farlow, M. R., Ghetti, B. F., & Benson, M. D. (1991) · Science · doi:10.1126/science.1925564 · Cited by 1,122 · see citing works

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988) · Nature · doi:10.1038/331528a0 · Cited by 1,093 · see citing works

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083 · see citing works

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

Ponte, P. A., Gonzalez‐DeWhitt, P. A., Schilling, J., Miller, J., Hsu, D. K., Greenberg, B., Davis, K. L., Wallace, W., Lieberburg, I. M., Fuller, F. H., et al. (1988) · Nature · doi:10.1038/331525a0 · Cited by 1,050 · see citing works

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

Demuro, A., Mina, E. W., Kayed, R., Milton, S. C. F., Parker, I., & Glabe, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500997200 · Cited by 1,038 · see citing works

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M. E., Romano, D. M., Hartshorn, M. A., Tanzi, R. E., & Bush, A. I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12817 · Cited by 1,009 · see citing works

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

Arispe, N. J., Rojas, E., & Pollard, H. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.567 · Cited by 921 · see citing works

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913 · see citing works

A mouse model for Down syndrome exhibits learning and behaviour deficits

Reeves, R. H., Irving, N. G., Moran, T. H., Wohn, A., Kitt, C., Sisodia, S. S., Schmidt, C., Bronson, R. T., & Davisson, M. T. (1995) · Nature Genetics · doi:10.1038/ng1095-177 · Cited by 913 · see citing works

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

Yankner, B. A., Dawes, L. R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L., & Neve, R. L. (1989) · Science · doi:10.1126/science.2474201 · Cited by 907 · see citing works

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 893 · see citing works

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 881 · see citing works

Normal and Abnormal Biology of the Beta-Amyloid Precursor Protein

Selkoe, D. J. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002421 · Cited by 827 · see citing works

Alzheimer's disease: experimental models and reality

Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works

The Genetics of Alzheimer's Disease

Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 784 · see citing works

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Crews, L., & Masliah, E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq160 · Cited by 772 · see citing works

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743 · see citing works

The genetics of Alzheimer disease

Tanzi, R. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006296 · Cited by 727 · see citing works

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

Lillis, A. P., Duyn, L. B. V., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 702 · see citing works

Identification and characterization of key kinetic intermediates in amyloid β-protein fibrillogenesis11Edited by F. Cohen

Kirkitadze, M. D., Condron, M. M., & Teplow, D. B. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4970 · Cited by 684 · see citing works

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works

Not just amyloid: physiological functions of the amyloid precursor protein family

Müller, U. C., Deller, T., & Korte, M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.29 · Cited by 634 · see citing works

Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian Chromosomes

Cox, D., Burmeister, M., Price, E. R., Kim, S., & Myers, R. (1990) · Science · doi:10.1126/science.2218528 · Cited by 618 · see citing works

Molecular genetics of early-onset Alzheimer’s disease revisited

Cacace, R., Sleegers, K., & Van Broeckhoven, C. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.01.012 · Cited by 617 · see citing works

The redox chemistry of the Alzheimer's disease amyloid β peptide

Smith, D. G., Cappai, R., & Barnham, K. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.02.002 · Cited by 608 · see citing works

DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

Yang, Y., Geldmacher, D., & Herrup, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02661.2001 · Cited by 607 · see citing works

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

Robakis, N. K. R. K., Ramakrishna, N., Wolfe, G. C., & Wisniewski, H. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4190 · Cited by 603 · see citing works

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 591 · see citing works

Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors

Wang, C., & Holtzman, D. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 589 · see citing works

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E., Lee, G. S., Fritz, L. C., & Oltersdorf, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7341 · Cited by 579 · see citing works

Biology of Amyloid: Structure, Function, and Regulation

Greenwald, J., & Riek, R. (2010) · Structure · doi:10.1016/j.str.2010.08.009 · Cited by 573 · see citing works

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

Raja, W. K., Mungenast, A. E., Lin, Y.-T., Ko, T., Abdurrob, F., Seo, J., & Tsai, L.-H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161969 · Cited by 569 · see citing works

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas‐Kramarski, R., JAFFE, E. A., Gandy, S., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10075 · Cited by 558 · see citing works

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

Rogers, J. T., Randall, J. D., Cahill, C. M., Eder, P. S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S. S., Utsuki, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207435200 · Cited by 551 · see citing works

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

Arispe, N. J., Pollard, H. B., & Rojas, E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10573 · Cited by 548 · see citing works

Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

Cuajungco, M. P., & Lees, G. J. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0163 · Cited by 540 · see citing works

Synaptic degeneration in Alzheimer's disease

Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works

γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

Sisodia, S. S., & St George-Hyslop, P. H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn785 · Cited by 512 · see citing works

The activities of amyloids from a structural perspective

Riek, R., & Eisenberg, D. S. (2016) · Nature · doi:10.1038/nature20416 · Cited by 504 · see citing works

Copper in the brain and Alzheimer’s disease

Hung, Y. H., Bush, A. I., & Cherny, R. A. (2009) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-009-0600-y · Cited by 496 · see citing works

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., & Strickland, D. K. (1995) · Cell · doi:10.1016/0092-8674(95)90320-8 · Cited by 489 · see citing works

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.

Mori, H., Takio, K., OGAWARA, M., & Selkoe, D. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41896-0 · Cited by 481 · see citing works

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

Kirschner, D. A., Inouye, H., Duffy, L. K., Sinclair, A. J., Lind, M., & Selkoe, D. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.19.6953 · Cited by 481 · see citing works

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

Saitoh, T., Sundsmo, M. P., Roch, J., Kimura, N., Cole, G. M., Schubert, D. A., Oltersdorf, T., & Schenk, D. B. (1989) · Cell · doi:10.1016/0092-8674(89)90096-2 · Cited by 471 · see citing works

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

Broeckhoven, C. V., Haan, J., Bakker, E., Hardy, J., Hul, W. V., Wehnert, A., der Vlis, M. V.-V., & Roos, R. A. C. (1990) · Science · doi:10.1126/science.1971458 · Cited by 471 · see citing works

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

Whitson, J. S., Selkoe, D. J., & Cotman, C. W. (1989) · Science · doi:10.1126/science.2928783 · Cited by 469 · see citing works

A Hundred Years of Alzheimer's Disease Research

Hardy, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.016 · Cited by 467 · see citing works

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

Oltersdorf, T., Fritz, L. C., Schenk, D. B., Lieberburg, I. M., Johnson‐Wood, K., Beattie, E. C., Ward, P. J., Blacher, R. W., Dovey, H. F., & Sinha, S. (1989) · Nature · doi:10.1038/341144a0 · Cited by 457 · see citing works

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

Epstein, C. J., Avraham, K. B., Lovett, M., Smith, S. H., Elroy‐Stein, O., Rotman, G., Bry, C., & Groner, Y. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8044 · Cited by 454 · see citing works

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

Milward, E. A., Papadopoulos, R., Fuller, S. J., Moir, R. D., Small, D. H., Beyreuther, K., & Masters, C. L. (1992) · Neuron · doi:10.1016/0896-6273(92)90228-6 · Cited by 453 · see citing works

REVIEW: Curcumin and Alzheimer’s disease

Hamaguchi, T., Ono, K., & Yamada, M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00147.x · Cited by 450 · see citing works

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

Buxbaum, J. D., Gandy, S., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A., & Greengard, P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.6003 · Cited by 450 · see citing works

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

Kent, S. A., Spires-Jones, T. L., & Durrant, C. S. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02196-w · Cited by 446 · see citing works

Tau phosphorylation: physiological and pathological consequences

Stoothoff, W. H., & Johnson, G. V. W. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.017 · Cited by 439 · see citing works

Clearance of Alzheimer's Aβ Peptide

Tanzi, R. E., Moir, R. D., & Wagner, S. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.024 · Cited by 431 · see citing works

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

Golde, T. E., Estus, S., Usiak, M., Younkin, L. H., & Younkin, S. G. (1990) · Neuron · doi:10.1016/0896-6273(90)90100-t · Cited by 431 · see citing works

Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology

HUANG, X., MOIR, R. D., TANZI, R. E., BUSH, A. I., & ROGERS, J. T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.012 · Cited by 425 · see citing works

Interactions of pathological proteins in neurodegenerative diseases

Spires‐Jones, T. L., Attems, J., & Thal, D. R. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1709-7 · Cited by 424 · see citing works

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

Mrak, R. E., Sheng, J. G., & Griffin, W. S. T. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90001-2 · Cited by 414 · see citing works

Probing the biology of Alzheimer’s disease in mice

Ashe, K. H., & Zahs, K. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.031 · Cited by 413 · see citing works

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406 · see citing works

New and evolving concepts in the neurotoxicology of lead☆

White, L. D., Cory‐Slechta, D. A., Gilbert, M. E., Tiffany‐Castiglioni, E., Zawia, N. H., Virgolini, M. B., Rossi‐George, A., Lasley, S. M., Qian, Y., & Basha, R. M. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.08.001 · Cited by 404 · see citing works

The amyloid precursor protein: beyond amyloid.

Zheng, H., & Koo, E. H. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-5 · Cited by 403 · see citing works

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

Wasco, W., Bupp, K., Magendantz, M., Gusella, J. F., Tanzi, R. E., & Solomon, F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10758 · Cited by 399 · see citing works

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Hamaguchi, T., Ono, K., Murase, A., & Yamada, M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090417 · Cited by 396 · see citing works

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

Dyrks, T., Weidemann, A., Multhaup, G., Salbaum, J. M., Lemaire, H.-G., Kang, J., Müller‐Hill, B., Masters, C. L., & Beyreuther, K. T. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02900.x · Cited by 394 · see citing works

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

Wasco, W., Gurubhagavatula, S., Paradis, M. D., Romano, D., Sisodia, S. S., Hyman, B. T., Neve, R. L., & Tanzi, R. E. (1993) · Nature Genetics · doi:10.1038/ng0993-95 · Cited by 392 · see citing works

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain

Neve, R. L. (1988) · Neuron · doi:10.1016/0896-6273(88)90166-3 · Cited by 388 · see citing works

THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY

Hussain, M. M., Strickland, D. K., & Bakillah, A. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.141 · Cited by 376 · see citing works

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

Cotman, C. W., & Anderson, A. J. (1995) · Molecular Neurobiology · doi:10.1007/bf02740836 · Cited by 374 · see citing works

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

Thal, D. R., Griffin, W. S. T., de Vos, R. A. I., & Ghebremedhin, E. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0366-2 · Cited by 372 · see citing works

BACE1: The β-Secretase Enzyme in Alzheimer's Disease

Vassar, R. J. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:105 · Cited by 369 · see citing works

A vector for expressing foreign genes in the brains and hearts of transgenic mice

Borchelt, D., Davis, J. A., Fischer, M., Lee, M. K., Slunt, H. H., Ratovitski, T., Regard, J. B., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., et al. (1996) · Genetic Analysis Biomolecular Engineering · doi:10.1016/s1050-3862(96)00167-2 · Cited by 362 · see citing works

Metallostasis in Alzheimer's disease

Ayton, S., Lei, P., & Bush, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.558 · Cited by 354 · see citing works

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

Schubert, D. A., Jin, L.-W., Saitoh, T., & Cole, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90237-7 · Cited by 353 · see citing works

Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

Prelli, F., Castaño, E. M., Glenner, G. G., & Frangione, B. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01087.x · Cited by 351 · see citing works

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

Kowall, N. W., & Kosik, K. S. (1987) · Annals of Neurology · doi:10.1002/ana.410220514 · Cited by 349 · see citing works

Biology and pathophysiology of the amyloid precursor protein

Zheng, H., & Koo, E. H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-27 · Cited by 346 · see citing works

The pathological association between down syndrome and Alzheimer disease

Mann, D. M. A. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90041-3 · Cited by 346 · see citing works

Proteolytic processing of Alzheimer’s β‐amyloid precursor protein

Zhang, H., Ma, Q., Zhang, Y., & Xu, H. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07519.x · Cited by 344 · see citing works

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

Siman, R. G., Card, J. P., Nelson, R. B., & Davis, L. G. (1989) · Neuron · doi:10.1016/0896-6273(89)90252-3 · Cited by 344 · see citing works

Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.

Patterson, D., Gardiner, K., Kao, F., Tanzi, R. E., Watkins, P., & Gusella, J. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8266 · Cited by 75 · see citing works

Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Jenkins, E. C., Devine-Gage, E. A., Robakis, N. K. R. K., Yao, X., Brown, W. T., Houck, G. E., Wolfe, G. C., Ramakrishna, N., Silverman, W. P., & Wı́sniewski, H. M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90551-7 · Cited by 19 · see citing works

The mouse homolog of the human amyloid β protein (AD-AP) gene is located on the distal end of mouse chromosome 16: Further extension of the homology between human chromosome 21 and mouse chromosome 16

Lovett, M., Goldgaber, D., Ashley, P. L., Cox, D., Gajdusek, D. C., & Epstein, C. J. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(87)80073-6 · Cited by 44 · see citing works

MINIREVIEW: Amyloid Protein in Alzheimer's Disease

Joachim, C. L., & Selkoe, D. J. (1989) · Journal of Gerontology · doi:10.1093/geronj/44.4.b77 · Cited by 21 · see citing works

β Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome

Delabar, J. M., Goldgaber, D., Lamour, Y. A., Nicole, A., Huret, J. L., GROUCHY, J. D., Brown, P., Gajdusek, D. C., & Sinet, P. (1987) · Science · doi:10.1126/science.2950593 · Cited by 187 · see citing works