The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21
Abstract
Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.
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“the added copy of APP in trisomy 21 was known to be associated with the early and invariable development of AD pathology in Down syndrome [52].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [52]
Citations
Cites
Detection of specific sequences among DNA fragments separated by gel electrophoresis
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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611
The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21
George‐Hyslop, P. S., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L. E., Watkins, P. C., Myers, R. H., Feldman, R. G., Pollen, D. A., Drachman, D. A., et al. (1987) · Science · doi:10.1126/science.2880399 · Cited by 1,160
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Dementia of the Alzheimer Type
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Research works printed but not linked: 2
- 1987, Cytogenet Cell Genet, 46, 491
- Van Broeckhoven, 1988, The familial Alzheimer's disease gene is located close to the centromere of chromosome 21, Am J Hum Genet, 43, A205
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Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659
Self-citationA Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,153
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.
(1991) · Europe PMC (PubMed Central) · Cited by 758
Molecular genetics of early-onset Alzheimer’s disease revisited
Cacace, R., Sleegers, K., & Van Broeckhoven, C. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.01.012 · Cited by 617
A Hundred Years of Alzheimer's Disease Research
Hardy, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.016 · Cited by 467
Self-citation
Metadata
- Authors
- Goate, A., Owen, M., James, L., Mullan, M., Rossor, M., Haynes, A., Farrall, M., Lai, L. C., Roques, P., Williamson, R., & Hardy, J.
- Affiliations
- St Mary's Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 333
- Issue
- 8634
- Pages
- 352-355
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2115363308
- Cited by
- 270
- References
- 20
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 3 · 2015: 18 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 32.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Alzheimer's disease, chromosome 21, genetic linkage, early-onset Alzheimer's disease, genetic susceptibility, familial Alzheimer's disease
- MeSH terms
- Adult, Alzheimer Disease, Chromosome Aberrations, Chromosome Mapping, Chromosomes, Human, Pair 21, Female, Humans, Genetic Linkage, Male, Middle Aged, Mutation, Recombination, Genetic, Polymorphism, Restriction Fragment Length, Blotting, Southern, Chromosome Disorders
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