The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Greatly increased luminal nitric oxide in ulcerative colitis
Abstract
A role for nitric oxide (NO) in ulcerative colitis has been suggested because mucosal NO synthase activity, measured by indirect assays, is increased in this disorder. We directly measured luminal NO in the colons of twelve controls and six patients with active ulcerative colitis. During colonoscopy, gas was aspirated from different parts of the colon and immediately analysed by a chemiluminescence technique. NO concentrations were more than 100 times higher in the patients than in the controls. Luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.
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In the citing paper
“This shift is particularly notable in the context of inflammatory bowel disease, where massive blooms of pathogenic, nitrate-reducing Salmonella and Escherichia coli are seen in response to inflammation[333,334,338,339].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [339]
In the citing paper
“which is then reduced to nitrite by commensal anaerobic bacteria on the tongue [22].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]
In the citing paper
“However, chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis induce inducible NOS (iNOS) and generate large quantities of NO [22,146,147], forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system [148,149].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]
In the citing paper
“Acidic disproportionation of nitrite can lead to increased levels of NO [84–86].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [86]
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Increased amount of nitric oxide in exhaled air of asthmatics
Alving, K., Weitzberg, E., & Lundberg, J. (1993) · European Respiratory Journal · doi:10.1183/09031936.93.06091368 · Cited by 1,232
Self-citationIntragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661
Self-citationNitric oxide synthase activity in ulcerative colitis and Crohn's disease
Boughton-Smith, N. K., Evans, S., Whittle, B. J. R., Moncada, S., Hawkey, C. J., COLE, A. T., & Balsitis, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91476-3 · Cited by 459
Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome
Lundberg, J., Weitzberg, E., Nordvall, S. L., Kuylenstierna, R., Jm, L., & Alving, K. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07081501 · Cited by 408
Self-citationIncreased nitric oxide synthesis in ulcerative colitis
Middleton, S. J., Shorthouse, M., & Hunter, J. O. (1993) · The Lancet · doi:10.1016/0140-6736(93)90211-x · Cited by 343
Nitric oxide synthase induction and intestinal epithelial cell viability in rats
Tepperman, B. L., Brown, J. F., & Whittle, B. J. R. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.2.g214 · Cited by 194
The rectal mucosa-associated microflora in patients with ulcerative colitis
Hartley, M. G., HUDSON, M. J., Swarbrick, E. T., Hill, M. J., Gent, A. E., Hellier, M. D., & Grace, R. H. (1992) · Journal of Medical Microbiology · doi:10.1099/00222615-36-2-96 · Cited by 80
Research works printed but not linked: 1
- Ji, 1989, Nitrate reductase of Escherichia coli as a NO-producing nitrite reductase, Biochem Arch, 5, 61
Cited by
Sorted by citations
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019
Nitric oxide signaling in health and disease
Lundberg, J. O., & Weitzberg, E. (2022) · Cell · doi:10.1016/j.cell.2022.06.010 · Cited by 879
Self-citationHigh nitric oxide production in human paranasal sinuses
Lundberg, J. O. N., Farkas-Szallasi, T., Weitzberg, E., Rinder, J., Lidholm, J., Änggåard, A., Hökfelt, T., Lundberg, J. M., & Alving, K. (1995) · Nature Medicine · doi:10.1038/nm0495-370 · Cited by 628
Self-citation
Metadata
- Authors
- Lundberg, J. O. N., Lundberg, J. M., Alving, K., & Hellström, P. M.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Lundberg, J.O.N.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 344
- Issue
- 8938
- Pages
- 1673-1674
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2054157046
- Cited by
- 266
- References
- 8
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 8 · 2014: 2 · 2013: 6 · 2012: 10
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- nitric oxide, ulcerative colitis, nitric oxide synthase, inflammatory bowel disease, chemiluminescence measurement, colon, disease surveillance
- MeSH terms
- Adult, Aged, Colitis, Ulcerative, Colon, Colonoscopy, Humans, Luminescent Measurements, Middle Aged, Nitric Oxide
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