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Greatly increased luminal nitric oxide in ulcerative colitis
Abstract
A role for nitric oxide (NO) in ulcerative colitis has been suggested because mucosal NO synthase activity, measured by indirect assays, is increased in this disorder. We directly measured luminal NO in the colons of twelve controls and six patients with active ulcerative colitis. During colonoscopy, gas was aspirated from different parts of the colon and immediately analysed by a chemiluminescence technique. NO concentrations were more than 100 times higher in the patients than in the controls. Luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.
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“This shift is particularly notable in the context of inflammatory bowel disease, where massive blooms of pathogenic, nitrate-reducing Salmonella and Escherichia coli are seen in response to inflammation[333,334,338,339].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [339]
In the citing paper
“which is then reduced to nitrite by commensal anaerobic bacteria on the tongue [22].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]
In the citing paper
“However, chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis induce inducible NOS (iNOS) and generate large quantities of NO [22,146,147], forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system [148,149].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]
In the citing paper
“Acidic disproportionation of nitrite can lead to increased levels of NO [84–86].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [86]
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Decreased development of necrotizing enterocolitis in IL-18-deficient mice
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Metabolic network of the gut microbiota in inflammatory bowel disease
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Bax is downregulated in inflamed colonic mucosa of ulcerative colitis
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Metadata
- Authors
- Lundberg, J. O. N., Lundberg, J. M., Alving, K., & Hellström, P. M.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Lundberg, J.O.N.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 344
- Issue
- 8938
- Pages
- 1673-1674
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2054157046
- Cited by
- 266
- References
- 8
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 8 · 2014: 2 · 2013: 6 · 2012: 10
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- nitric oxide, ulcerative colitis, nitric oxide synthase, inflammatory bowel disease, chemiluminescence measurement, colon, disease surveillance
- MeSH terms
- Adult, Aged, Colitis, Ulcerative, Colon, Colonoscopy, Humans, Luminescent Measurements, Middle Aged, Nitric Oxide
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