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Cited by 541Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyRespiratory Support and Mechanisms

Randomised controlled trial of respiratory rehabilitation

GOLDSTEIN, R·1994·The Lancet
DOI 10.1016/s0140-6736(94)90568-1
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Abstract

Disability associated with chronic obstructive pulmonary disease has led to the development of rehabilitation programmes that aim to increase exercise tolerance and improve quality of life. Many reports of the benefits of rehabilitation have been from uncontrolled trials and unsupervised programmes. In view of the commitment asked of patients, their families, and health-care professionals, rehabilitation should be justified by a demonstration of sustained improvement over conventional treatment. We undertook a prospective randomised controlled trial of respiratory rehabilitation in 89 subjects (44 men, 45 women) aged 66 (SD 7) years with severe but stable chronic obstructive pulmonary disease who received rehabilitation or conventional community care. The treatment group were rehabilitated as inpatients for 8 weeks and supervised as outpatients for 16 weeks. Primary outcome measures of exercise tolerance and quality of life were made at baseline and repeated at 12, 18, and 24 weeks. The difference between baseline and last follow-up was significant for 6 min walk distance (37.9 m [95% CI 10.8-65.0], p = 0.0067) and submaximal cycle time (4.7 min [2.1-7.3]). There were also significant differences in questionnaire assessment of dyspnoea (p = 0.0061), emotional function (p = 0.0150), mastery (p = 0.0002), and dyspnoea index (p = 0.0053). Improvements in exercise tolerance and quality of life can be achieved and sustained for 6 months in patients undergoing respiratory rehabilitation compared with those receiving conventional care.

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Crossref · 10.1016/s0140-6736(94)90568-1

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  • Participation in supervised whole-body exercise training has been shown in several randomized controlled trials to improve symptoms of anxiety and depression as a consequence of training-related gains in functional capacity.

    “Subsequent participation in supervised whole-body exercise training has been shown in several randomized controlled trials95–98 to improve symptoms of anxiety and depression as a consequence of training-related gains in functional capacity.”

    From Anxiety and Depression in COPD (2008) · cites this paper as [95]

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Authors
GOLDSTEIN, R.
Affiliations
University of Toronto (CA)
Corresponding author
GOLDSTEIN, R
ORCID
GOLDSTEIN, R
Venue
The Lancet
Publisher
Elsevier BV
Published
1994-11
Volume
344
Issue
8934
Pages
1394-1397
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(94)90568-1
OpenAlex
W2041369332
Cited by
541
References
28
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 15
FWCI
26.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
pulmonary rehabilitation, chronic obstructive pulmonary disease, exercise tolerance, quality of life, 6-minute walk distance, dyspnea, emotional functioning, mastery, inpatient rehabilitation, conventional care
MeSH terms
Aged, Exercise Therapy, Female, Humans, Lung Diseases, Obstructive, Male, Prospective Studies, Quality of Life, Surveys and Questionnaires, Respiration, Outcome Assessment, Health Care, Exercise Tolerance

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