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Cited by 454Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesAutomotive and Human Injury Biomechanics

Stalning af amyloid percursor protein to study axonal damage in mild head Injury

Blumbergs, P.C., Scott, G., Manavis, J., Wainwright, H., Simpson, D.A., McLean, A.J.·1994·The Lancet
DOI 10.1016/s0140-6736(94)91712-4
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Abstract

The most common definition of cerebral concussion is that of a transient loss of neurological function without macroscopic or microscopic abnormality in the brain. However, some patients have persistent symptoms and subtle neuropsychological deficits, particularly affecting memory. We have studied five patients aged 59-89 years who sustained mild concussive head injury and died of other causes (2-99 days post-injury). Immunostaining with an antibody to amyloid precursor protein, a marker of fast axonal transport, showed multifocal axonal injury in all five. All had axonal damage in the fornices, which are important in memory function.

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Crossref · 10.1016/s0140-6736(94)91712-4

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9 of 9 references verified0 citation errors · 0 not checkable

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  • APP accumulates in traumatized axons after all severities of TBI and has been detected many months post-injury.

    “For example, APP accumulates in traumatized axons after all severities of TBI and has been detected many months post-injury (129–131).”

    From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [130]

  • Pathological studies of acute concussion and post-concussive syndrome are rare and often include subjects with more severe traumatic injuries, but multifocal traumatic axonal injury, microhemorrhage, and microglial activation have been reported.

    “Pathological studies of acute concussion and PCS are rare and often include subjects with more severe traumatic injuries, but multifocal traumatic axonal injury TAI, microhemorrhage, and microglial activation have been reported [12, 150].”

    From The neuropathology of sport (2014) · cites this paper as [12]

  • Blumbergs and colleagues examined five cases of human concussive head injury using amyloid precursor protein immunohistochemistry and reported multifocal axonal injury in the fornices, a major hippocampal projection pathway involved in memory.

    “Blumbergs and colleagues examined five cases of human concussive head injury using amyloid precursor protein (APP) immunohistochemistry and reported multifocal axonal injury in the fornices, a major hippocampal projection pathway involved in memory [12].”

    From The neuropathology of sport (2014) · cites this paper as [12]

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Authors
Blumbergs, P. C., Scott, G., Manavis, J., Wainwright, H., Simpson, D. A., & McLean, A. J.
Affiliations
South Australia Pathology (AU)
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1994-10
Volume
344
Issue
8929
Pages
1055-1056
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(94)91712-4
OpenAlex
W2068767931
Cited by
454
References
9
Citations by year
2026: 7 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 14 · 2017: 21 · 2016: 15 · 2015: 32 · 2014: 22 · 2013: 16 · 2012: 21
FWCI
8.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
Keywords
amyloid precursor protein, axonal injury, mild traumatic brain injury, concussion, fornix, memory impairment, postmortem brain, fast axonal transport, immunostaining
MeSH terms
Aged, Aged, 80 and over, Axons, Axonal Transport, Brain Chemistry, Brain Concussion, Craniocerebral Trauma, Humans, Immunohistochemistry, Middle Aged, Biomarkers, Amyloid beta-Protein Precursor

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