Cited by 317Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

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Posterior cingulate cortex in Alzheimer's disease

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MINOSHIMA, S·1994·The Lancet

DOI 10.1016/s0140-6736(94)92871-1

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Distribution of cerebral degeneration in Alzheimer's disease: A clinico-pathological study
Brun, A., & Gustafson, L. (1976) · Archiv f�r Psychiatrie und Nervenkrankheiten · doi:10.1007/bf00367450 · Cited by 397
In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM.
Kuhl, D. E., Koeppe, R. A., Fessler, J. A., Minoshima, S., Ackermann, R. J., Carey, J. E., Gildersleeve, D. L., Frey, K. A., & Wieland, D. M. (1994) · PubMed · Cited by 117
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How to use neuroimaging biomarkers in the diagnosis framework of neurodegenerative diseases?
Chételat, G. (2022) · Revue Neurologique · doi:10.1016/j.neurol.2022.03.006 · Cited by 7
Atypical Localization and Dissociation between Glucose Uptake and Amyloid Deposition in Cognitively Normal APOE*E4 Homozygotic Elders Compared with Patients with Late-Onset Alzheimer’s Disease
Pardo, J. V., Lee, J. T., & Initiative, A. D. N. (2018) · eNeuro · doi:10.1523/eneuro.0396-17.2018 · Cited by 8
“The initial region of hypometabolism in early LOAD localized typically to the PCC/precuneus with subsequent extension into biparietal and inferior temporal regions (Minoshima et al., 1994, 1997).”
Background
Complementarity of visual and voxel-based FDG-PET analysis to detect MCI-like hypometabolic pattern in elderly patients with hypertension and isolated memory complaints
Gucht, A. V. D., Verger, A., Yagdigul, Y., Poussier, S., Joly, L., Watfa, G., Bénétos, A., Karcher, G., & Marie, P. (2014) · Acta Radiologica · doi:10.1177/0284185114542366 · Cited by 9
“While the temporo-parietal involvement in the AD is well known (17), the most characteristic functional impairment in MCI patients, that also relates to the risk of developing AD, is found in the PCC (4).”
Background
Hypoperfusion in the posterior cingulate cortex is associated with lower bone mass density in elderly women with osteopenia and Alzheimer’s disease
Takano, Y., Mutoh, T., Tatewaki, Y., Seki, T., Yamamoto, S., Odagiri, H., Arai, H., & Taki, Y. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13217 · Cited by 7
Progress in neuroimaging of Alzheimer’s disease
Matsuda, H. (2007) · Psychogeriatrics · doi:10.1111/j.1479-8301.2007.00175.x · Cited by 7
Effect of N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960), an Antidementia Drug with a Novel Mechanism of Action, on Regional Cerebral Blood Flow and Glucose Metabolism in Aged Rhesus Macaques Studied with Positron Emission Tomography
Noda, A., Takamatsu, H., Matsuoka, N., Koyama, S., Tsukada, H., & Nishimura, S. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.050245 · Cited by 7
“Previous investigations suggested a correlation between rCBF, rCMRglc, and cognitive function: rCBF and rCMRglc declined in both normal aged human and AD patients (Herholz et al., 1990; Minoshima et al., 1994; De Santi et al., 1995; Loessner et al., 1995); rCBF positively correlated with mini-mental state examination…”
BackgroundResult
Role of mitochondria in neuronal function and survival in the enteric and central nervous systems
KURAL, İ., Mombeek, L. M. M., & Wilson, D. M. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-06053-5 · Cited by 8
“Furthermore, PET imaging in early AD stages reveals brain hypometabolism, indicating impaired mitochondrial function and glucose metabolism [165, 166].”
Evaluation of the difference-correction effect of the gamma camera systems used by easy Z-score Imaging System (eZIS) analysis
Yamämoto, Y., Onoguchi, M., Kawakami, K., Haramoto, M., Wake, R., Horiguchi, J., & Kitagaki, H. (2014) · Annals of Nuclear Medicine · doi:10.1007/s12149-014-0807-z · Cited by 6
“12 It has been reported that in the interpretation of cerebral blood flow images from 13 either positron emission tomography (PET) or single photon emission computed 14 tomography (SPECT), a diagnostic improvement is realized by statistical image analysis 15 using Statistical Parametric Mapping (SPM) [1, 2] or three-d…”
Background
Divergent neurodegenerative patterns: Comparison of [18F] fluorodeoxyglucose-PET- and MRI-based Alzheimer’s disease subtypes
Wheatley, S., Mohanty, R., Poulakis, K., Levin, F., Muehlboeck, J., Nordberg, A. K., Grothe, M. J., Ferreira, D., & Westman, E. (2024) · Brain Communications · doi:10.1093/braincomms/fcae426 · Cited by 5
“At a group level, the expected pattern of temporo-parietal hypometabolism 50-54 was found in the AD group.”
Correlation between Regional Cerebral Blood Flow and EEG Upper/Low Alpha Frequency Power Ratio in Mild Cognitive Impairment
Moretti, D. V., Prestia, A., Binetti, G. G., Zanetti, O. O., & Frisoni, G. B. (2013) · Journal of Neurology & Neurophysiology · Cited by 5
The utility of cerebral perfusion SPECT analysis using SPM8, eZIS and vbSEE for the diagnosis of multiple system atrophy-parkinsonism
Sakurai, K., Imabayashi, E., Ito, K., Tokumaru, A. M., Ozawa, Y., Muto, M., Nakagawa, M., Okita, K., Matsukawa, N., & Shibamoto, Y. (2014) · Annals of Nuclear Medicine · doi:10.1007/s12149-014-0928-4 · Cited by 5
“In such cases, the eZIS program, as well as the three-dimensional stereotactic surface projections (3D-SSP) program [24], enables the objective evaluation of the cerebral perfusion SPECT image of each individual case by the superimpose display of Z-scores on the standard brain map, and is useful to diagnose neurodegen…”
Method
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification
Wang, Z., Zhan, Q., Tong, B., Yang, S. Y., Hou, B., Huang, H., Saykin, A. J., Thompson, P. M., Davatzikos, C. A., & Shen, L. (2024) · iScience · doi:10.1016/j.isci.2024.109212 · Cited by 5
“In clinical trials, the result shows that posterior cingulate and temporal pole are changed severely by the AD 31 pathologic.”
Background
The Neurotoxic Effects of Continuous Cocaine and Amphetamine in Habenula
Ellison, G. D. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-477-1_8 · Cited by 5
“In Alzheimer’s disease, a sizable increase has been reported in neurofibrillary tangles and neuritic plaques in olfactory cortex compared to many other brain regions (Reyes et al. 1993); the olfactory bulb also shows substantial pathology (Struble and Clark 1992).”
BackgroundInfluential
Sodium-azide-induced learning deficits in rats: Time course and corresponding pathology
Croll, S. D., Greene, N. A., Lindsay, R. M., & Wiegand, S. J. (1997) · Psychobiology · doi:10.3758/bf03327025 · Cited by 5
Neurostatistical imaging for diagnosing dementia: translational approach from laboratory neuroscience to clinical routine
Imabayashi, E., & Inoue, T. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1464-x · Cited by 4
“[3] showed that glucose metabolism decreases in the posterior cingulate in Alzheimer’s disease (AD) using Neurostat (Department of Radiology, University of Washington, Seattle, WA[3], http:// www.rad.washington.edu/research/Research/groups/ nbl/neurostat-3d-ssp).”
Method
Maladie d’alzheimer, hippocampe et neuroimagerie
Mevel, K., Chételat, G., Desgranges, B., & Eustache, F. (2006) · L Encéphale · doi:10.1016/s0013-7006(06)76306-0 · Cited by 4
“Cette inconstance dans les résultats existe également chez les patients MA : certains auteurs concluent à une absence d’hypométabolisme ou d’hypoperfusion de l’hippocampe (7, 20, 31, 32, 33, 34, 46, 50) et d’autres rapportent un dysfonctionnement hippocampique (8, 25, 27, 38, 48, 49, 51, 54, 55, 61).”
Background
Advance prediction of Mild Cognitive Impairment (MCI) using 99mTc-ECD SPECT brain blood flow imaging
Kawasaki, Y. (2008) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.45.202 · Cited by 4
Brain Behaviour Relationships in Dementia (Neuropsychology)
Sutherland, J., Dougall, N. J., & Ebmeier, K. P. (2003) · KARGER eBooks · doi:10.1159/000073164 · Cited by 4
Parkinson Dementia: PET Findings
Bohnen, N. I., & Frey, K. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-54307-4_16 · Cited by 3
Evaluation of Optimal Threshold of Z Score Map for Statistical Brain Image Analysis
Sakai, T., Onishi, H., & Miyazoe, K. (2015) · Japanese Journal of Radiological Technology · doi:10.6009/jjrt.2015_jsrt_71.4.325 · Cited by 3
Donepezil (Aricept)
Hara, Y., & Kawabe, H. (2019) · Springer eBooks · doi:10.1007/978-981-13-8906-1_11 · Cited by 3
Brain FDG PET for the Etiological Diagnosis of Clinically Uncertain Cognitive Impairment During Delirium in Remission
Mathies, F. L., Lange, C., Maeurer, A., Apostolova, I. I., Klutmann, S., & Buchert, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200530 · Cited by 3
“FDGPETwithapattern characteristicofAD(includingtypicalAlzheimer’ disease[43],posteriorcorticalatrophy[44],and thelogopenicvariantofprimaryprogressiveaphasia [45]),frontotemporallobardegeneration(including the behavioral variant [46], nonﬂuent/agrammatic and semantic primary progressive aphasia…”
Positron Emission Tomography and Magnetic Resonance Imaging in the Study of Cognitively Normal Persons at Differential Genetic Risk for Alzheimer’s Dementia
Reiman, E. M., Caselli, R. J., Chen, K., & Alexander, G. E. (2004) · Springer eBooks · doi:10.1007/978-3-642-59300-0_12 · Cited by 3
Neuropathological Changes in Visuospatial Systems in Alzheimer's Disease
von Gunten, A., Giannakopoulos, P., Bouras, C., & Hof, P. R. (2004) · KARGER eBooks · doi:10.1159/000079968 · Cited by 3
Parkinsonian Dementias: PET Findings
Kanel, P., Müller, M. L. T. M., & Bohnen, N. I. (2020) · Springer eBooks · doi:10.1007/978-3-030-53168-3_16 · Cited by 4
Impact of shortening time on diagnosis of 18F-florbetaben PET
Trinh, P. T. H., Kim, D.-Y., Choi, K., & Kim, J. (2024) · EJNMMI Research · doi:10.1186/s13550-024-01181-8 · Cited by 3
Association of Aspiration Pneumonia-Related Factors with the Incidence of Healthcare-Associated Pneumonia in Elderly with Dementia
Miyamoto, T., Karita, K., Kozaki, K., & Ebihara, T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14176186 · Cited by 2
“Furthermore, a decrease in cerebral blood flow in the posterior cingulate and the angular gyrus were also considered an important diagnostic criterion [14].”
Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang’s method
Sohara, K., Kiriyama, T., Mizumura, S., Ishiwata, A., Yamazaki, M., Kimura, K., & Kumita, S. (2020) · Annals of Nuclear Medicine · doi:10.1007/s12149-020-01477-4 · Cited by 2
Characterizing Cerebral Perfusion Changes in Subjective Cognitive Decline Using Single Photon Emission Computed Tomography: A Case-Control Study
Lin, Y., Lin, L., Kao, C.-H., Chen, I.-J., Cheng, C., Tsai, C.-L., Lee, J., Sung, Y., Chou, C.-H., Yen, S.-Y., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226855 · Cited by 2
“As noted by Minoshima et al. [50] and Kumakura et al. [51], the posterior cingulate often shows the earliest decrease in blood flow in AD.”
Advances in Dementia Imaging
Clopton, D., & Druzgal, T. J. (2013) · Seminars in Roentgenology · doi:10.1053/j.ro.2013.10.006 · Cited by 2
Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351
Imabayashi, E., Saitoh, Y., Tsukamoto, T., Sakata, M., & Takano, H. (2022) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000004425 · Cited by 2
Consciousness and Dementia: How the Brain Loses Its Self
Pietrini, P., Salmon, É., & Nichelli, P. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374168-4.00016-2 · Cited by 2
Association between Regional Cerebral Blood Flow and Mini-Mental State Examination Score in Patients with Alzheimer’s Disease
Saitô, H., Kashiwakura, I., Tsushima, M., & Mariya, Y. (2020) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405616666200124125130 · Cited by 2
Application of 18F‐PET Imaging for the Study of Alzheimer's Disease
Någren, K., & Rinne, J. O. (2008) · Elsevier eBooks · doi:10.1016/b978-0-444-53086-8.00002-3 · Cited by 2
Brain fluorine-18 fluorodeoxyglucose imaging with dual-head coincidence gamma camera: comparison with dedicated ring-detector positron emission tomography.
Fukuchi, K., Hayashida, K., Moriwaki, H., Fukushima, K., Kume, N., Katafuchi, T., Sago, M., Takamiya, M., & Ishida, Y. (2000) · PubMed Central · Cited by 2
Statistical Diagnostic Radiology
UCHIDA, Y. (2002) · Japanese Journal of Radiological Technology · doi:10.6009/jjrt.kj00000921533 · Cited by 2
Statistical Evaluation of Single-Photon Emission Computed Tomography Image Using Smoothed Bootstrap Method
Tsukamoto, M., Hatabu, A., Takahashi, Y., Matsuda, H., Okamoto, K., Yamashita, N., & Takagi, T. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00843 · Cited by 1
Predicting conversion from mild cognitive impairment to Alzheimer’s disease using [18F]FDG PET with deep learning and radiomics: a systematic review and meta-analysis
Kiani, I., Allami, P., Amanizadeh, I., Mohammadzadeh, S., Martineau, P., & Harsini, S. (2026) · Clinical and Translational Imaging · doi:10.1007/s40336-026-00762-y · Cited by 1
“Historically, a seminal observation in AD has been the observation of hypometabolism in the PCC, a posterior medial region included in Papez’s circuit [ 50 ].”
Dementia Due to Neurodegenerative Disease: Molecular Imaging Findings
Ossenkoppele, R., Booij, J., Scheltens, P., & van Berckel, B. N. M. (2014) · Springer eBooks · doi:10.1007/978-3-642-54307-4_9 · Cited by 1
Specific Composite Biomarker Profiles for β-Amyloid Accumulation in Peripheral Blood in Healthy Subjects Relevant to Biological Factors: Comparison with Patients with Dementia
Satoh, K., Sato‐Ueshima, M., Kagami‐Katsuyama, H., Nakamura, M., Ogata, A., Maeda‐Yamamoto, M., & Nishihira, J. (2024) · Journal of Biotechnology and Biomedicine · doi:10.26502/jbb.2642-91280125 · Cited by 1
Voxel-based Specific Regional Analysis System for Alzheimer’s Disease and Arterial Spin Labeling in Brain Magnetic Resonance Imaging: A Comparative Study
Okada, Y., Ohno, N., Kitahara, Y., Niioka, H., Tanaka, K., Ueda, H., Tsujii, K., & Sato, M. (2025) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/0115734056337828250526070304 · Cited by 1
NMDA Receptor Dysfunction in Alzheimer’s Disease
Olney, J. W., Wozniak, D. F., Ishimaru, M. J., & Farber, N. B. (1997) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4116-4_17 · Cited by 1
Mild Cognitive Impairment Neuroimaging Markers for Early Diagnosis of Dementia
Huang, C. C. (2003) · Figshare · Cited by 1
Relationships between Cognitive Performance and Cerebral Metabolism in Alzheimer's Disease
Colette, F., der Linden, M. V., & Salmon, É. (2000) · Current psychology letters · doi:10.4000/cpl.107 · Cited by 3
PET and SPECT imaging of dementia—past, present, and future
Minoshima, S. (2002) · International Congress Series · doi:10.1016/s0531-5131(01)00562-3 · Cited by 1
Self-citation
Functional neuroimaging in Alzheimer's disease
Matsuda, H. (2006) · Radiation Medicine · doi:10.1007/s11604-006-2408-9 · Cited by 1
Recovery of function after lesions of the anterior thalamic nuclei: CA1 neuromorphology
Harland, B. C. (2013) · doi:10.26021/5935 · Cited by 1
Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography
Tashiro, M., Okamura, N., Watanuki, S., Furumoto, S., Furukawa, K., Funaki, Y., Iwata, R., Kudo, Y., Arai, H., Watabe, H., et al. (2011) · IGI Global eBooks · doi:10.4018/978-1-60960-559-9.ch029 · Cited by 1
XVIIIth International Symposium on Cerebral Blood Flow and Metabolism
(1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x9701701s01 · Cited by 1
[18F]Fluorodeoxyglucose Positron Emission Tomography in Alzheimer Disease and Related Disorders
MIYAZAWA, N., & Shinohar, T. (2012) · InTech eBooks · doi:10.5772/30326
Epigenetic dysregulation and the pathophysiology of Alzheimer’s disease
Mastroeni, D. (2013) · doi:10.26481/dis.20130503dm
The role of the medial temporal lobe in discriminating complex object and scene stimuli
Shine, J. P. (2013) · ORCA Online Research @Cardiff (Cardiff University)
Multivariate analysis of eigenvalues and eigenvectors in tensor based morphometry
Rajagopalan, V., Schwartzman, A., Hua, X., Leow, A., Thompson, P. M., & Leporé, N. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2073737
“Atrophy of the cingulate cortex and associated loss of memory and executive function are well-documented in patients with AD.16 Our results allow us to understand the mechanism of uniform loss of tissue in various regions of patients with AD when compared to control subjects.”
Result
Methylene blue, spatial memory and anterior thalamic lesions relevant to amnesic disorders.
Edlin, S. M. (2011) · UC Research Repository (University of Canterbury) · doi:10.26021/5865
ORIGINAL RESEARCH White Matter Alterations in Cognitively Normal apoE 2 Carriers: Insight into Alzheimer Resistance?
Chiang, G. C.-Y., Wang, Z., & Schuff, N. W. (2012)
Statistical brain mapping of 18F-FDG PET in Alzheimer's disease: validation of anatomic standardization for atrophied brains.
Ishii, K., Willoch, F., Minoshima, S., Drzezga, A. E., Ficaro, E. P., Cross, D. J., Kuhl, D. E., & Schwaiger, M. (2001) · PubMed · Cited by 205
Self-citation
Age Related Changes in Cognition and Brain: A Focus on Progestogens
Braden, B. B. (2012)
Emission Imaging in Dementia
Price, J. C., Lopresti, B. J., & Villemagne, V. L. (2012) · Neuromethods · doi:10.1007/7657_2012_47
13 Functional Imaging with FDG-PET in Mild Cognitive Impairment
Herholz, K. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328875.003.0013 · Cited by 1
Research Article A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
Rafii, M. S., Baumann, T. L., Bakay, R. A. E., Ostrove, J. M., Siffert, J. O., Fleisher, A., Herzog, C. D., Barba, D., Pay, M. M., Salmon, D. P., et al. (2013)
Altered Regional CBF Correlates with Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Profile in the Patients with Memory Lapse
Inaki, A., & Funaki, N. (2016) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000351
FDG-PET in Alzheimer’s Disease
Inui, Y., Ito, K., & Kato, T. (2017) · Springer eBooks · doi:10.1007/978-4-431-55133-1_9
Evaluation of the Endo-Lysosomal System and the Ubiquitin-Proteasome System in Neurodegenerative Diseases
Sjödin, S. (2018) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Fact, Fiction, or Evolution: Mechanism Hypothesis of Alzheimer’s Disease
Pardo, J. V. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.83824
Aging-related hypometabolism in the anterior cingulate cortex mediates the relationship between age vs. executive function but not vs. memory in cognitively intact eldersPreprint
Pardo, J. V., Nyabwari, S. M., Lee, J. T., & ADNI (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/635219
“The earliest neuroimaging biomarkers for AD are hypometabolism, atrophy, and amyloid deposition in the posterior cingulate cortex (PCC) and precuneus as well as in other parietal cortices (Minoshima et al., 1994; Rowe et al., 2007; Chételat et al., 2016).”
Background
Physical Exercise and the Resting Brain
Hugenschmidt, C. E., Laurienti, P. J., & Burdette, J. H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3293-7_16
Apport de l'analyse multidisciplinaire dans la compréhension des mécanismes physiopathologiques des démences
Deramecourt, V. (2009) · HAL
Consciousness and Dementia
Pietrini, P., Salmon, É., & Nichelli, P. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-800948-2.00013-3
Alpha and Theta EEG Rhythms Activity Reveal Deep Changes in Resting Brain State in Subjects with Prodromal Alzheimer's Disease
Moretti, D. V., Prestia, A., Binetti, G. G., Zanetti, O. O., & Frisoni, G. B. (2014) · Journal of Aging and Gerontology · doi:10.12974/2309-6128.2014.02.01.3
“The working hypothesis of the present study is that an increase in alpha3/alpha2 EEG frequency power ratio would like to be associated with lower brain perfusion in specific brain areas, as demonstrated in a large body of literature with SPECT studies [23-37].”
Result
Individualized Summary Assessment of Detailed Neuropsychological Testing for the Etiological Diagnosis of Newly Detected Cognitive Impairment in Hospitalized Geriatric Patients
Maeurer, A., Himmel, G., Lange, C., Mathies, F. L., Apostolova, I. I., Peters, O., & Buchert, R. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221273
“…nuclearmedicineraterswithrespecttothepresence of an AD-characteristic pattern of hypometabolism including both the ‘typical’ AD pattern [70] and ‘atypical’ AD patterns such as the ‘posterior’ AD pattern [71], the ‘logopenic’ AD pattern [72], and the ‘frontal’ AD pattern [73].”
Central Nervous System Nuclear Imaging
Muhleman, M., Brown, R. K. J., Wong, K. K., Al-Dulaimi, R., & Bohnen, N. I. (2025) · Seminars in Roentgenology · doi:10.1053/j.ro.2025.04.006
Appendixe B: Level of Function Scale
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app02
Chapter 20. Supporting Family Caregivers
Gallagher-Thompson, D. E., Lonergan, K. H., Holland, J. M., China, D., & Ashford, J. W. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg20
Chapter 1. Dementia and Alzheimer Disease: Ancient Greek Medicine to Modern Molecular Biology
Weiner, M. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg01
Appendixe C: Mental Status Examination
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app03
Chapter 13. Traumatic Brain Injury
Bigler, E. D. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg13
Appendixe E: Alzheimer’s Disease Cooperative Study: Activities of Daily Living Inventory
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app05
Chapter 22. Ethical Issues and Patterns of Practice
Hughes, J. C. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg22
Chapter 21. Legal Issues
Frolik, L. A. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg21
Chapter 14. Other Causes of Dementia
ZAMRINI, E. Y., & Quiceno, M. E. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg14
Chapter 15. Psychiatric Disorders in People With Dementia
Steinberg, M., & Lyketsos, C. G. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg15
Appendixe G: Agitated Behavior in Dementia Scale
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app07
Chapter 23. Biomarkers for the Dementias
Bürger, K., & Hampel, H.-J. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg23
Chapter 16. Pharmacological Treatment of Neuropsychiatric Symptoms
Yaari, R., & Tariot, P. N. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg16
Appendixe J: Resources
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app10
Chapter 19. Management of Advanced Dementia
Volicer, L., & Simard, J. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg19
Appendixe D: Neurological Examination
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app04
Front Matter
(2009) · doi:10.1176/appi.books.9781585628940.fm02
Chapter 17. Behavioral and Environmental Management
Hilgeman, M. M., Burgio, L. D., & Allen, R. S. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg17
Preface
(2009) · doi:10.1176/appi.books.9781585628940.fm05
Appendixe A: History Form
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app01
Chapter 3. Neuropsychiatric Assessment and Diagnosis
Weiner, M., Garrett, R., & Bret, M. E. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg03
Chapter 7. Cognitive Disorders as Psychobiological Processes
Weiner, M. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg07
Chapter 12. Frontotemporal Dementia
Lipton, A. M., & Boxer, A. L. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg12
Appendixe F: Neuropsychiatric Inventory: Community Dwelling Version
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app06
Chapter 11. Dementia With Lewy Bodies and Other Synucleinopathies
Tarawneh, R. M., & Galvin, J. E. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg11
Chapter 5. Neuropsychological Assessment in Dementia
Cullum, C. M., & Lacritz, L. H. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg05
Chapter 2. Epidemiology and Impact of Dementia
Savva, G. M., & Brayne, C. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg02
Appendixe I: Quality of Life in Late-Stage Dementia (QUALID) Scale
(2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.app09
Chapter 4. Medical Evaluation and Diagnosis
Lipton, A. M., & Rubin, C. D. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585628940.lg04

Authors: MINOSHIMA, S.
Affiliations: University of Michigan (US)
Corresponding author: MINOSHIMA, S
ORCID: MINOSHIMA, S
Venue: The Lancet
Publisher: Elsevier BV
Published: 1994-09
Volume: 344
Issue: 8926
Pages: 895
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(94)92871-1
OpenAlex: W2045977955
Cited by: 316
References: 2
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 14 · 2013: 15 · 2012: 16
FWCI: 4.57
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: U.S. Department of Energy (DE‐FG02‐, DE-FG02-87ER60561)
National Institutes of Health (5r01ns024896-15)
National Institute of Neurological Disorders and Stroke (R01 NS24896)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: posterior cingulate cortex, Alzheimer's disease, neuroimaging, neurodegeneration
MeSH terms: Alzheimer Disease, Gyrus Cinguli, Humans, Tomography, Emission-Computed

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