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Posterior cingulate cortex in Alzheimer's disease
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“In comparison with the control group, the group with probable Alzheimer's disease had significantly reduced rates of glucose metabolism bilaterally in prefrontal (PF), parietal, temporal, and posterior cingulate (PC) regions.12,13”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [12]
In the citing paper
“could be affected relatively early, 12”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [12]
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Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
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“Taken together, these results provide an impetus for future clinical trials of intranasal insulin therapy and for further mechanistic studies of insulin’s role in the pathogenesis of AD.”
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“Each scan was compared with the NL database controlling for the global activity using Neurostat scaling procedures, and Z scores (Z 5 [meansubject – meandatabase]/SDdatabase) were calculated voxel by voxel at a threshold of P # 0.01 (1-sided) corresponding to Z $ 2.33 (19,33, 34 ).”
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“The six brain regions included the PCC, which is associated with unusually early CMRgl reductions in AD (4, 28); the middle temporal gyrus (MTG); the hippocampal field CA1 (HIP) and entorhinal cortex (EC), which are also metabolically affected in AD (1, 20); the superior frontal gyrus (SFG), which is associated with p…”
BackgroundDiffering patterns of temporal atrophy in Alzheimer's disease and semantic dementia
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“…In functional imaging studies, the most consistently replicated clinical ¢nding associated with the posterior cingulate cortex has been decreased metabolic activity of this region in AD (Nyback et al., 1991; Minoshima et al., 1994; Vander Borght et al., 1997; Ishi et al., 1997).”
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“Therefore, it is the complete regional pattern of metabolic impairment of the posterior cingulate and temporoparietal cortices, more accentuated than frontal cortex deficits, together with the relative preservation of the primary sensorimotor and visual cortices, basal ganglia, and cerebellum that defines the distinct…”
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“and hippocampus in MCI subjects, which were associated with a higher risk of progressive cognitive decline (Arnaiz et al., 2001; Huang et al., 2002; Johnson et al., 1998; Kitayama et al., 2001; Minoshima et al., 1994; Okamura et al., 2002; Rodriguez et al., 2000).”
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“These findings are also consistent with prior FDG-PET studies [6, 7, 37, 38, 39, 40].”
ResultAge differences in the neural systems supporting human allocentric spatial navigation
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“Their largest decrement was in the posterior cingulate cortex (PCC) (Reiman et al., 1996), as in the case of AD ( Minoshima et al., 1994 ).”
BackgroundInfluentialJohnson, S. C., Schmitz, T. W., Moritz, C. H., Meyerand, M. E., Rowley, H. A., Alexander, A. L., Hansen, K. W., Gleason, C. E., Carlsson, C. M., Ries, M. L., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.017 · Cited by 239
“PC hypometabolism and blood flow are frequent findings in mild AD [42] and MCI [66], and in people with genetic risk for AD [48,49,58].”
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Spatially augmented LPboosting for AD classification with evaluations on the ADNI dataset
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“, 2001) and impaired metabolism (Hoffman et al., 2000; Matsuda, 2001; Minoshima et al., 1994) can be identified (in structural and functional images) in Mild Cognitive Impaired (MCI) and AD patients, as well as at-risk individuals (Small et al.”
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“first reported decreased glucose metabolism of the posterior cingulate cortex in Alzheimer disease (AD) (3).”
BackgroundSelf-citationA critical discussion of the role of neuroimaging in mild cognitive impairment*
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“The reduction in rCMRG in the cingulate has been shown to precede the changes in temporoparietal areas (103) and to be already present in the preclinical phase of AD (33).”
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Self-citationSaccade Reward Signals in Posterior Cingulate Cortex
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“Our finding of Alzheimer's Disease and Mild Cognitive Impairment as an important theme is also in agreement with findings of the neuroimaging literature where PCC hypometabolism is prevalent, see, e.g., (Minoshima et al., 1994; Volkow et al., 2002; Nybäck et al., 1991).”
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“Hypometabolism in the posterior cingulate cortex was found in an early stage of AD ( 20,21 ) and in APOE4 homozygote subjects ( 22 ).”
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“Fluorodeoxyglucose (FDG) positron emission tomography (PET) studies of persons with Alzheimer’s disease (AD) (Minoshima et al., 1994, 1995, 1997; Mielke et al., 1994; Reiman et al., 1996) and mild cognitive impairment (MCI) characteristically show preferential and progressive neocortical reductions…”
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“Alterations in imaging[3–8], cytochromeoxidase(CO) histochemistry [9], neuronal transcriptomic [10], and genetic association [11] studies have raised the possibility that mitochondrial processes may be involved in the pathogenic cascade.”
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“This pattern of hypometabolism is in accordance with previous ®ndings (for reviews, see for example Minoshima et al., 1994; Ibanez et al., 1998; Demetriades, 2002; Wolf et al., 2003).”
Result18F-FDG PET imaging analysis for computer aided Alzheimer’s diagnosis
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“…in the processing of extrafoveal information have been noted in patients with dementia of the Alzheimer's type (Benson et al. 1988), but no systematic study has been performed on this group of patients in the light of the recent ¢ndings of Kuhl and associates (Minoshima et al. 1994, 1997).”
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“This pattern of hypometabolism is in accordance with previous findings [12,39,43].”
ResultCorrelations Between Apolipoprotein E ε4 Gene Dose and Whole Brain Atrophy Rates
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“The neurodegenerative process in AD is thought to initiate in the entorhinal cortex and then disseminates into the hippocampus [9] and neocortical regions in the temporal, parietal and frontal lobes [10].”
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“Of especial note is the repeated finding of posterior cingulate hypoactivity in Alzheimer's disease (Minoshima, Foster, & Kuhl, 1994 ; Minoshima et al, 1997 ).”
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“The importance of gaining this understanding is underscored by the fact that the RSC is hypometabolic in Alzheimer’s Disease (AD) (Matsuda, 2001; Minoshima, Giordani, et al., 1997; Minoshima, Foster, & Kuhl, 1994 ), as well as in people with risk factors for AD (Reiman, Chen, et al., 2004; Small et al., 2000; Reiman,…”
BackgroundAltered deactivation in individuals with genetic risk for Alzheimer's disease
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Perfusion abnormalities in prodromal AD
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Preclinical Evidence of Alzheimer Changes
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“For comparison purposes, CMRglu subtraction images from a separate cohort of 37 patients with clinicallydiagnosedprobableADand22age-matchedcontrols imagedunder similar conditionswereused togenerateZ scoremaps of typical AD-related cortical hypometabolism.(17) To confirm the findings of the voxelwise analyses, correlat…”
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“Previous studies have found early structural degeneration (Lehmann et al., 2010), amyloid deposition (Buckner et al., 2005), and altered functional energy metabolism in this region in Alzheimer’s disease (Minoshima et al., 1994).”
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“…imaging, such as fluorodeoxyglucose positron emission tomography (FDG PET), has shown that persons with Alzheimer's disease (AD) demonstrate consistent glucose uptake reductions across large areas of association cortex (Minoshima et al., 1994, 1995, 1997; Mielke et al., 1994; Reiman et al., 1996).”
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“[5] showed a metabolic reduction in the posterior cingulate gyri in patients with AD and substantiated the histological change in an in vivo study.”
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Self-citationNeural substrates participating in acquisition of facial familiarity: an fMRI study
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“global scaling here is thus consistent with previous studies using the same scaling procedure in patients with aMCI or even with mild AD compared to controls (Minoshima et al., 1994; Ibanez et al., 1998; Ishii et al., 1998; Herholz et al., 2002; Chételat et al., 2003; Kawachi et al., 2006).”
BackgroundResultInfluentialAge-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
Noda, A., Ohba, H., Kakiuchi, T., Futatsubashi, M., Tsukada, H., & Nishimura, S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02558-1 · Cited by 88
MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning
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Looking beyond the hippocampus: old and new neurological targets for understanding memory disorders
Aggleton, J. P. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0565 · Cited by 96
Chen, M.-K., Mecca, A. P., Naganawa, M., Gallezot, J., Toyonaga, T., Mondal, J., Finnema, S. J., Lin, S.-F., O’Dell, R. S., McDonald, J. W., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211004312 · Cited by 84
APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease
Wolf, A. B., Caselli, R. J., Reiman, E. M., & Valla, J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.10.011 · Cited by 84
“…has been consistently noted as a region of particular significance in the metabolic alterations in AD, because it shows very early and comparatively large reductions in CMRgl (Minoshima et al., 1994) and sits at the convergence point of multiple metabolic covariance networks (Salmon et al., 2009).”
BackgroundNakashima, T., Nakayama, N., Miwa, K., Okumura, A., Soeda, A., & Iwama, T. (2007) · PubMed Central · Cited by 78
Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease
von Gunten, A., Bouras, C., Kövari, E., Giannakopoulos, P., & Hof, P. R. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.003 · Cited by 75
Matsuda, H., Mizumura, S., Nagao, T., Ota, T., Iizuka, T., Nemoto, K., Kimura, M., Tateno, A., Ishiwata, A., Kuji, I., et al. (2007) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e328013eb8b · Cited by 75
Perkins, M., Wolf, A. B., Chavira, B., Shonebarger, D., Meckel, J. P., Leung, L., Ballina, L. E., Ly, S., Saini, A., Jones, T. B., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151205 · Cited by 79
“…APOE4 carriers consistently demonstrate reductions (when compared to APOE4 non-carriers) in energy metabolism via measures of mitochondrial function and glucose metabolism, even decades before possible disease onset [20, 28] and in a pattern consistent with findings in AD patients [19, 31, 40].”
ResultBeta2-Adrenergic Receptor and Astrocyte Glucose Metabolism
Dong, J., Chen, X., Cui, M., Yu, X., Pang, Q., & Sun, J. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9742-4 · Cited by 76
Jenkins, T. A., Vann, S. D., Amin, E., & Aggleton, J. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03421.x · Cited by 70
Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease
Nakano, S., Yamashita, F., Matsuda, H., Kodama, C., & Yamada, T. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000089215 · Cited by 69
“In this study, 39.1p of the AD patients exhibited delusions, with this figure well within the range reported in the previous studies. Gender difference has not been found in studies performed in Western countries on a large number of subjects [ ,”
ResultClinical application of positron emission tomography for diagnosis of dementia
Ishii, K. (2002) · Annals of Nuclear Medicine · doi:10.1007/bf02988628 · Cited by 72
Kanetaka, H., Matsuda, H., Asada, T., Ohnishi, T., Yamashita, F., Imabayashi, E., Tanaka, F., Nakano, S., & Takasaki, M. (2004) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1491-3 · Cited by 69
“Although recent advances in the computer-assisted statistical analysis of positron emission tomography (PET) or single-photon emission computed tomography (SPECT) after anatomical image standardization have made it easier to detect regional metabolic or perfusion changes in the early stage of AD [1, 2, 3, 4], there ha…”
Imaging Alzheimer's disease: clinical applications
Minoshima, S. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00099-6 · Cited by 65
“1, AD) [18], which revealed a preclinical metabolic reduction in the posterior cingulate and cinguloparietal transitional cortices (see Fig.”
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Vogt, B. A., Vogt, L. J., Vrana, K. E., Gioia, L., Meadows, R. S., Challa, V. R., Hof, P. R., & Van Hoesen, G. W. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6852 · Cited by 64
Kawasaki, K., Ishii, K., Saito, Y., Oda, K., Kimura, Y., & Ishiwata, K. (2008) · Annals of Nuclear Medicine · doi:10.1007/s12149-007-0099-7 · Cited by 64
“It is well recognized that rCMRglc decreases in these association cortices are observed in Alzheimer’s disease [8–12], and the decrease in the posterior cingulate and precuneus is considered to be an early sign of this disorder [13, 14].”
BackgroundCaselli, R. J., Osborne, D., Reiman, E. M., Hentz, J. G., Barbieri, C. J., Saunders, A. M., Hardy, J., Graff‐Radford, N. R., Hall, G. R., & Alexander, G. E. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00577-9 · Cited by 62
Tracking Alzheimerʼs disease in transgenic mice using fluorodeoxyglucose autoradiography
Reiman, E. M., Uecker, A., Gonzalez-Lima, F., Minear, D., Chen, K., Callaway, N. L., Berndt, J. D., & Games, D. (2000) · NeuroReport · doi:10.1097/00001756-200004070-00018 · Cited by 62
Relatively Preserved Hippocampal Glucose Metabolism in Mild Alzheimer’s Disease
Ishii, K., Sasaki, M., Yamaji, S., Sakamoto, S., Kitagaki, H., & Mori, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017083 · Cited by 56
Tc-99m HMPAO SPECT in the Differential Diagnosis of the Dementias With Histopathologic Confirmation
Bonte, F. J., Harris, T. S., Hynan, L. S., Bigio, E. H., & White, C. L. (2006) · Clinical Nuclear Medicine · doi:10.1097/01.rlu.0000222736.81365.63 · Cited by 54
“The diagnostic importance of the posterior cingulate sign has been demonstrated by Minoshima et al.6 Although this procedure may improve sensitivity and specificity, we have as yet had too few patients come to autopsy to make a valid statistical determination of such improvement.”
MethodRodriguez, G., Vitali, P., Canfora, M., Calvini, P., Girtler, N. G., Leo, C. D., Piccardo, A., & Nobili, F. M. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00321-3 · Cited by 56
Bonte, F. J., Harris, T. S., Roney, C. A., & Hynan, L. S. (2004) · PubMed · Cited by 53
Cross, D. J., Anzai, Y., Petrie, E. C., Martin, N., Richards, T. L., Maravilla, K. R., Peskind, E. R., & Minoshima, S. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.116558 · Cited by 51
“In the early 1990s, 18F-FDG PET imaging combined with quantitative voxelbased analytic methods depicted this distinct pattern, including the indication of hypometabolism in the posterior cingulate cortex–precuneus region (15).”
BackgroundSelf-citation
Metadata
- Authors
- MINOSHIMA, S.
- Affiliations
- University of Michigan (US)
- Corresponding author
- MINOSHIMA, S
- ORCID
- MINOSHIMA, S
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 344
- Issue
- 8926
- Pages
- 895
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2045977955
- Cited by
- 316
- References
- 2
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 14 · 2013: 15 · 2012: 16
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- U.S. Department of Energy (DE‐FG02‐, DE-FG02-87ER60561)
- National Institutes of Health (5r01ns024896-15)
- National Institute of Neurological Disorders and Stroke (R01 NS24896)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- posterior cingulate cortex, Alzheimer's disease, neuroimaging, neurodegeneration
- MeSH terms
- Alzheimer Disease, Gyrus Cinguli, Humans, Tomography, Emission-Computed
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