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Cited by 417

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Maternal vitamin A deficiency and mother-to-child transmission of HIV-1

Open access
Semba, R.D, Chiphangwi, J.D, Miotti, P.G, Dallabetta, G.A, Hoover, D.R, Canner, J.K, Saah, Aj·1994·The Lancet
DOI 10.1016/s0140-6736(94)93056-2
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Abstract

Studies show that around 10-40% HIV-positive women will give birth to children who are also infected. However, the risk factors for transmission from mother to child are not well understood and the effects of maternal nutritional status are unknown. We conducted a study of vitamin A status in pregnant women as a risk factor for mother-to-child transmission of HIV in Malawi. Serum vitamin A, height, weight, CD4 T-cell counts, and duration of breastfeeding were measured in 338 HIV-positive mothers whose infant's HIV serostatus was known. Mother-to-child transmission of HIV was 21.9% among mothers whose infants survived to 12 months of age. Mean vitamin A concentration in 74 mothers who transmitted HIV to their infants was lower than that in 264 mothers who did not transmit HIV to their infants (0.86 [0.03] vs 1.07 [0.02], p < 0.0001). We divided HIV positive mothers to 4 groups, those with vitamin A concentrations of less than 0.70, between 0.70 and 1.05, between 1.05 and 1.40, and greater than or equal to 1.40 mumol/L. The mother-to-child transmission rates for each group were 32.4%, 26.2%, 16.0%, and 7.2%, respectively (p < 0.0001). Maternal CD4 cell counts, CD4%, and CD4/CD8 ratio were also associated with increased mother-to-child transmission of HIV. Maternal age, body-mass index, and breastfeeding practices were not significantly associated with higher mother-to-child transmission. Our study suggests that maternal vitamin A deficiency contributes to mother-to-child transmission of HIV.

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Metadata

Authors
Semba, R. D., Chiphangwi, J. D., Miotti, P. G., Dallabetta, G. A., Hoover, D. R., Canner, J. K., & Saah, A.
Venue
The Lancet
Publisher
Elsevier BV
Published
1994-06
Volume
343
Issue
8913
Pages
1593-1597
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(94)93056-2
OpenAlex
W2169273126
Cited by
417
References
16
FWCI
24.07
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. https://app.cochat.ai/papers/10.1016/s0140-6736(94)93056-2
The paper
Semba, R. D., Chiphangwi, J. D., Miotti, P. G., Dallabetta, G. A., Hoover, D. R., Canner, J. K., & Saah, A. (1994). Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. The Lancet. https://doi.org/10.1016/s0140-6736(94)93056-2

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.