Is Alzheimer's disease an apolipoprotein E amyloidosis?

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Wisniewski, T., & Frangione, B. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90444-c · Cited by 802

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

Miller, D. L., Papayannopoulos, I. A., Styles, J., Bobin, S. A., Lin, Y. Y., Biemann, K., & Iqbal, K. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1112 · Cited by 510

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

van Duijn, C. M., de Knijff, P., Cruts, M., Wehnert, A., Havekes, L. M., Albert Hofman, D., & Broeckhoven, C. V. (1994) · Nature Genetics · doi:10.1038/ng0594-74 · Cited by 457

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

(1994) · PubMed Central · Cited by 441

Presenilin-1 is associated with Alzheimer's disease amyloid.

Wısnıewskı, T., Dowjat, W. K., Permanne, B., Palha, J. A., Kumar, A., Gallo, G., & Frangione, B. (1997) · Europe PMC (PubMed Central) · Cited by 25

A distinct subfraction of Aβ is responsible for the high‐affinity Pittsburgh compound B‐binding site in Alzheimer's disease brain

Matveev, S. V., Spielmann, H. P., Metts, B. M., Chen, J., Onono, F. O., Zhu, H., Scheff, S. W., Walker, L. C., & LeVine, H. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12815 · Cited by 25

Sodium Dodecyl Sulfate-Resistant Complexes of Alzheimer’s Amyloid β-Peptide with the N-Terminal, Receptor Binding Domain of Apolipoprotein E

Golabek, A. A., Kida, E., Walus, M., Perez, C., Wısnıewskı, T., & Soto, C. A. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76354-5 · Cited by 24

Molecular biology of brain aging and neurodegenerative disorders

Wısnıewskı, T., & Frangione, B. (1996) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1996-1132 · Cited by 24

Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease

Tomiyama, T., Corder, E. H., & Mori, H. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050428 · Cited by 22

Future horizons in Alzheimer's disease research

Wısnıewskı, T., & Drummond, E. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.08.001 · Cited by 20

Apolipoprotein E and Apolipoprotein A-1 Knock-Out Mice Readily Develop Amyloid A Protein Amyloidosis

Elliott-Bryant, R., & Cathcart, E. S. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4397 · Cited by 20

Cytotoxicity of lipid-free apolipoprotein B

Morita, S., Deharu, Y., Takata, E., Nakano, M., & Handa, T. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.08.012 · Cited by 18

Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: investigation with the confocal laser scan microscope

Nishiyama, E., Iwamoto, N., Ohwada, J., & Arai, H. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01329-7 · Cited by 18

Apolipoprotein E and Amyloidogenesis

Frangione, B., Castaño, E. M., Wısnıewskı, T., Ghiso, J. A., Prelli, F., & Vidal, R. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514924.ch9 · Cited by 18

Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele

Gal, J., Katsumata, Y., Zhu, H., Srinivasan, S., Chen, J., Johnson, L. A., Wang, W.-X., Golden, L. R., Wilcock, D. M., Jicha, G. A., et al. (2022) · The American Journal of Pathology · doi:10.1016/j.ajpath.2021.11.013 · Cited by 17

Apolipoprotein E-Related Neurotoxicity as a Therapeutic Target for Alzheimer's Disease

Marques, M. A., & Crutcher, K. A. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:327 · Cited by 17

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II

Mao, Y., Zlatic, C. O., Griffin, M. D. W., Howlett, G. J., Todorova, N., Yarovsky, I., & Gooley, P. R. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00535 · Cited by 16

Promotion of synthetic amyloid β-peptide fibrillization by cell culture media and cessation of fibrillization by serum

Węgiel, J., Chauhan, A., Wı́sniewski, H. M., Nowakowski, J., Wang, K.-C., & LeVine, H. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12739-7 · Cited by 16

Cerebral Amyloid Angiopathy Associated With Hemorrhage: Immunohistochemical Study of 41 Biopsy Cases.

Izumihara, A., Ishihara, T., Hoshii, Y., & Ito, H. (2001) · Neurologia medico-chirurgica · doi:10.2176/nmc.41.471 · Cited by 16

Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study

Tsiolaki, P. L., Katsafana, A. D., Baltoumas, F. A., Louros, N. N., & Iconomidou, V. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092274 · Cited by 15

Role of A β Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease

Holtzman, D. M., & Zloković, B. V. (2007) · Springer eBooks · doi:10.1007/978-0-387-35135-3_11 · Cited by 15

Vaccines for conformational disorders

Sadowski, M. J., & Wısnıewskı, T. (2004) · Expert Review of Vaccines · doi:10.1586/14760584.3.3.279 · Cited by 14

Apolipoprotein E intersects with amyloid-β within neurons

Konings, S. C., Nyberg, E., Martinsson, I., Torres-Garcia, L., Klementieva, O. L., Almeida, C. G., & Gouras, G. K. (2023) · Life Science Alliance · doi:10.26508/lsa.202201887 · Cited by 12

USE OF FUSED CIRCULATIONS TO INVESTIGATE THE ROLE OF APOLIPOPROTEIN E AS AMYLOID CATALYST AND PERIPHERAL SINK IN ALZHEIMER'S DISEASE

Nilsson, L. N. G., Gografe, S., Costa, D. A., Hughes, T., Dressler, D., & Potter, H. (2012) · Technology & Innovation · doi:10.3727/194982412x13462021398010 · Cited by 13

Colocalization of Apolipoprotein AI in Various Kinds of Systemic Amyloidosis

Sakata, N., Hoshii, Y., Nakamura, T., Kiyama, M., Arai, H., Omoto, M., Morimatsu, M., & Ishihara, T. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.4a6387.2005 · Cited by 13

Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease☆

Carrette, O., BURGESS, J., Burkhard, P. R., LANG, C., COTE, M., Rodrigo, N., Hochstrasser, D. F., & SANCHEZ, J. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.05.019 · Cited by 13

Biochemical assay for amyloid β deposits to distinguish Alzheimer's disease from other dementias

Kaplan, B., Haroutunian, V., Koudinov, A. R., Patael, Y., Pras, M., & Gallo, G. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(98)00190-9 · Cited by 11

Antiproteases and Cells in the Pathogenesis of β2-Microglobulin Amyloidosis: Role of α2-Macroglobulin and Macrophages

Argilés, À., Mourad, G., Gouin, A., & Schmitt‐Bernard, C. (2000) · The Nephron journals/Nephron journals · doi:10.1159/000045707 · Cited by 10

β2‐Microglobulin amyloidosis

Argilés, À. (1996) · Nephrology · doi:10.1111/j.1440-1797.1996.tb00117.x · Cited by 10

A study of apolipoproteins E and A-I in cutaneous amyloids

Chang, Y.-T., Tsai, S., Wang, W. J., Hong, C., Huang, C., & Wong, C. K. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04402.x · Cited by 12

Apolipoprotein E4 genotype is not a risk factor for systemic AA amyloidosis or familial amyloid polyneuropathy

Lovat, L. B., Booth, S. E., Booth, D. R., Madhoo, S., Holmgren, G., Hawkins, P. N., Soutar, A. K., & Pepys, M. B. (1995) · Amyloid · doi:10.3109/13506129509036920 · Cited by 9

In Silico Analysis of the Antagonist Effect of Enoxaparin on the ApoE4–Amyloid-Beta (Aβ) Complex at Different pH Conditions

Aguilar-Pineda, J. A., Paco-Coralla, S. G., Febres-Molina, C., Gamero-Begazo, P. L., Shrivastava, P., Vera-López, K. J., Dávila-Del-Carpio, G., López-Casaperalta, P., Gómez, B., & Cardenas, C. L. L. (2022) · Biomolecules · doi:10.3390/biom12040499 · Cited by 7

Apolipoprotein E Genotype: The Innocent Bystander or Active Bridge Between Metabolic Syndrome and Cognitive Impairment?

Frisardi, V. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111568 · Cited by 7

Immunotherapy for Alzheimer‘s Disease

Steinitz, M. O. (2009) · Immunotherapy · doi:10.2217/imt.09.3 · Cited by 7

Solution Conditions Affect the Ability of the K30D Mutation To Prevent Amyloid Fibril Formation by Apolipoprotein C-II: Insights from Experiments and Theoretical Simulations

Mao, Y., Todorova, N., Zlatic, C. O., Gooley, P. R., Griffin, M. D. W., Howlett, G. J., & Yarovsky, I. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00266 · Cited by 6

Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease

Asiamah, E. A., Feng, B., Guo, R., Zhang, W., He, J., Kong, D., Dong, T., Ma, J., & Cui, H. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0115 · Cited by 6

Statins for the treatment of Alzheimer's disease and dementia

McGuinness, B., Bullock, R. A., Craig, D., Kerr, E., & Passmore, P. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007514 · Cited by 7

Non-Anticoagulant Actions of Glycosaminoglycans (GAGs)

Cornelli, U. (1996) · Springer eBooks · doi:10.1007/978-1-4613-0371-8_20 · Cited by 5

Pericytes and the Neurovascular Unit: The Critical Nexus of Alzheimer Disease Pathogenesis?

Cercy, S. P. (2021) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2020.00062 · Cited by 4

Apolipoproteins in Different Amyloidoses

Sadowski, M., & Wısnıewskı, T. (2007) · Springer eBooks · doi:10.1007/0-387-25919-8_6 · Cited by 3

Oxidative Modification of Apolipoprotein E3 and Its Biological Significance

Hara, S., Tanaka, T., Yamada, M., Nagasaka, Y., & Nakamura, K. (1998) · Springer eBooks · doi:10.1007/978-4-431-68476-3_77 · Cited by 3

Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.

(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2

The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview

Morelli, L., Perry, G. L., & Tagliavini, F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/709613 · Cited by 2

Identification of apolipoprotein E-derived amyloid within cholesterol granulomas of leopard geckos (Eublepharis macularius)

IKEDA, M., Kondo, H., Murakami, T., Iwaide, S., Itoh, Y., & Shibuya, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-64643-y · Cited by 2

[The scavenger receptor and its importance in amyloid processes].

Aguilar-Gaytán, R., & Mas‐Oliva, J. (2002) · PubMed · Cited by 1

Cellular pathogenesis of Alzheimer's disease

Sloop, G. D. (1999) · Medical Hypotheses · doi:10.1054/mehy.1998.0730 · Cited by 1

Role of Apolipoprotein E in Alzheimer’s Disease: Clues from its Structure

Weisgraber, K. H., & Dong, L. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_2 · Cited by 1

Imaging the Morphology and Structure of Apolipoprotein Amyloid Fibrils

Mok, Y.-F., Teoh, C. L., Howlett, G. J., & Griffin, M. D. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394431-3.00022-5 · Cited by 1

Cardiovascular factors in dementia

Bidzan, L. (2022) · Psychiatria Polska · doi:10.12740/pp/150052 · Cited by 1

Visualization of Apolipoprotein E-Binding Amyloid Plaques in Postmortem Alzheimer’s Disease Brains Using a Novel Fluorescent Probe THK-5320

Harada, R., Kudo, K., Soto, G. C., Iwata, R., Yanai, K., Taki, Y., Kudo, Y., Furumoto, S., & Okamura, N. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00882 · Cited by 1

Apolipoprotein E and inclusion body myositis

Garlepp, M. J., & Mastaglia, F. L. (1996) · Annals of Neurology · doi:10.1002/ana.410400603 · Cited by 1

Chaperoning Amyloid in Alzheimer’s Disease: The Art of Avoiding Sticky Situations?

Frangione, B., Castaño, E. M., Prelli, F., Soto, C. A., Ghiso, J. A., & Wısnıewskı, T. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_13 · Cited by 1

Apolipoprotein E: Structural and Functional Interactions with Amyloid β

Stine, W. B., & LaDu, M. J. (2005) · Wiley eBooks · doi:10.1002/9783527619344.ch10 · Cited by 1

Influence of genetic variability and external regulating factors on amyloid-beta peptide aggregation

Hubin, E. (2014) · doi:10.3990/1.9789036537643

Peptides Inhibitor of Amyloidogenesis in Alzheimer’s Disease

Soto, C. A., Prelli, F. C., Frangione, B., Kindy, M. S., & de Beer, F. C. (1997) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4116-4_15

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Apolipoprotein E Carboxyl-terminal Fragments Are Complexed to Amyloids A and L

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Apolipoprotein E and Alzheimer's disease

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

(1994) · PubMed Central · Cited by 441