Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Wisniewski, Thomas; Frangione, Blas

doi:10.1016/0304-3940(92)90444-c

Cited by 802Alzheimer's disease research and treatmentsAmyloidosis: Diagnosis, Treatment, OutcomesPrion Diseases and Protein Misfolding

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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Wisniewski, Thomas, Frangione, Blas·1992·Neuroscience Letters

DOI 10.1016/0304-3940(92)90444-c

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Abstract

Many biochemically diverse proteins can give rise to amyloid fibrils; however, they are all accompanied by P component and glucosaminoglycans. With antibodies specific to apolipoprotein E (apo E) we used immunohistochemical techniques to test for the presence of this protein in both cerebral and systemic amyloid. We found apo E immunoreactivity in all tested types of cerebral and systemic amyloid. In amyloid deposits apo E P, component and glucosaminoglycans may be acting as 'pathological molecular chaperones'. The latter we define as a group of unrelated proteins that induce beta-pleated conformation in amyloidogenic polypeptides.

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Along with other amyloid-associated proteins, apoE is found in amyloid plaques.
“Along with other amyloid-associated proteins, apoE is found in amyloid plaques (Namba et al., 1991; Wisniewski and Frangione, 1992).”
From Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis (2012) · cites this paper as Wisniewski and Frangione, 1992
ApoE coaggregates with both parenchymal plaques and CAA.
“Many studies demonstrated that ApoE coaggregates with both parenchymal plaques and CAA [30,31].”
From Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease (2017) · cites this paper as [30]

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693 · see citing works

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Cuthbert, J.A. and Lipsky, P.E., Modulation of human lymphocyte response by low density lipoprotein (LDL): enhancement but not immunosuppression is mediated by LDL receptors, Proc. Natl. Acad. Sci. U.S.A., 81 (1984) 4539-4543.

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Authors: Wisniewski, T., & Frangione, B.
Affiliations: NYU Langone Health (US)
Corresponding author: Frangione, Blas
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1992-02
Volume: 135
Issue: 2
Pages: 235-238
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(92)90444-c
OpenAlex: W1965496447
Cited by: 802
References: 1
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 19 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 15 · 2014: 12 · 2013: 18 · 2012: 15
FWCI: 35.50
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 4415 d)
Locations: Neuroscience Letters (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG008721, AG-08721)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR02594)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Keywords: apolipoprotein E, amyloid fibrils, cerebral amyloid, P component, glycosaminoglycans, amyloidogenic proteins, immunoreactivity
MeSH terms: Amyloid, Serum Amyloid P-Component, Apolipoproteins E, Brain Chemistry, Glycosaminoglycans, Humans, Nervous System Diseases, Microscopy, Immunoelectron, Paraffin Embedding

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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