Cited by 1,525Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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Schmechel, D E, Saunders, A M, Strittmatter, W J, Crain, B J, Hulette, C M, Joo, S H, Pericak-Vance, M A, Goldgaber, D +1 more·1993·Proceedings of the National Academy of Sciences

Abstract

Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer disease (AD). We examined the possibility that commonly observed variability in A beta deposition in late-onset AD might be related to apolipoprotein E genotype (APOE gene; the two most common alleles are 3 and 4), since APOE4 is a susceptibility gene for late-onset AD and apolipoprotein E interacts strongly with A beta in vitro. In an autopsy series of brains of late-onset AD patients, we found a strong association of APOE4 allele with increased vascular and plaque A beta deposits. Late-onset AD patients with one or two APOE4 alleles have a distinct neuropathological phenotype compared with patients homozygous for APOE3.

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Crossref · 10.1073/pnas.90.20.9649

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Authors
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D.
Affiliations
  • Duke Medical Center (US)
  • Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.
Venue
Proceedings of the National Academy of Sciences
Published
1993-10-15
Volume
90
Issue
20
Pages
9649-9653
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2001688761
Cited by
1,525
References
37
Citations by year
2026: 14 · 2025: 19 · 2024: 40 · 2023: 26 · 2022: 30 · 2021: 39 · 2020: 26 · 2019: 32 · 2018: 33 · 2017: 35 · 2016: 44 · 2015: 36 · 2014: 46 · 2013: 47 · 2012: 41
FWCI
48.88
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r35ag007922-07)
  • National Institute on Aging (AG05 128, P50AG005128, AG07922)
  • National Center for Research Resources (RR-30)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amyloid-beta, apolipoprotein E, APOE ε4, APOE3, late-onset Alzheimer's disease, cerebral cortex, amyloid plaques, cerebral amyloid angiopathy, vascular amyloid deposits, genetic susceptibility
MeSH terms
Aged, Alzheimer Disease, Apolipoproteins E, Cerebral Cortex, Disease Susceptibility, Homozygote, Humans, Prospective Studies, Retrospective Studies, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Neurofibrillary Tangles, Neurofilament Proteins

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