The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK
Abstract
Background People who have a low birthweight show increased death rates from coronary heart disease and a higher prevalence for its risk factors. These findings have led to the hypothesis that the disease is programmed in fetal life. The aim of this study was to explore whether risk of stroke in adult life was linked to impaired fetal growth.Methods We ascertained deaths from stroke and coronary heart disease in 13 249 men in two cohorts from Hertfordshire and Sheffield, UK. We related death rates from these disease to body size at birth, weight at 1 year, and to measurements of the mothers' pelvises.Findings Death rates from both stroke and coronary heart disease tended to be highest in men whose birthweight had been low. Standardised mortality ratios (SMRs) for stroke fell by 12% (95% Cl 1-22) and for coronary heart disease by 10% (6-14) between each of five groupings of increasing birthweight (< or = 5.5 lb, 5.6-6.5 lb, 6.6-7.5 lb, 7.6-8.5 lb, and > 8.5 lb). Mortality from stroke was most strongly associated with low birthweight in relation to head size, and low placental weight in relation to head size. These patterns of growth occurred in offspring of mothers with flat bony pelvises. The SMR in sons of these women was 184 (67-396) compared with 104 (78-138) in the remainder of the cohort. In contrast, mortality from coronary heart disease was associated with small head circumference, thinness or shortness at birth and an altered ratio of placental weight to birthweight.Interpretation Stroke may originate in poor nutrition during the mother's childhood, which deforms the bony pelvis and subsequently impairs her ability to sustain the growth of the placenta and fetus in late pregnancy. Coronary heart disease, on the other hand, seems to originate in adaptations made by the fetus to inadequate delivery of nutrients when it occurs for reasons other than failure of placental growth.
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“The risk of cardiovascular disease in adult men in relation to the birth weight to placental weight ratio does not follow a linear fashion as one might expect, but rather a “U” shaped pattern with heart-related death rates being lowest when placental weight is ~19% of birth weight (Figure 5) (25, 217, 361).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [361]
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Cites
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Self-citationFetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
Self-citationINFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
BARKER, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91340-1 · Cited by 2,892
Self-citationFetal nutrition and cardiovascular disease in adult life
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Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
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Early growth and death from cardiovascular disease in women.
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Research works printed but not linked: 2
- Rich-Edwards, 1995, Birthweight, breastfeeding and the risk of coronary heart diseases in the nurses' health study, Am J Epidemiol, 141, 578
- Bernard, 1952, The size and shape of the female pelvis, Edin Med J, 59, 1
Cited by
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The origins of the developmental origins theory
Barker, D. J. P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01809.x · Cited by 2,955
Self-citationDevelopmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765
Self-citationFetal nutrition and adult disease
Godfrey, K. M., & Barker, D. J. P. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1344s · Cited by 1,329
Self-citationCatch-up growth in childhood and death from coronary heart disease: longitudinal study
Eriksson, J. G., Forsén, T., Tuomilehto, J. O., Winter, P. D., Osmond, C., & Barker, D. J. P. (1999) · Ambulatory Child Health · doi:10.1136/bmj.318.7181.427 · Cited by 1,144
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Metadata
- Authors
- Martyn, C., Barker, D., & Osmond, C.
- Affiliations
- Southampton General Hospital (GB)
- ORCID
- Osmond, C
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 348
- Issue
- 9037
- Pages
- 1264-1268
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2015470285
- Cited by
- 381
- References
- 21
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 9 · 2015: 15 · 2014: 15 · 2013: 19 · 2012: 18
- FWCI
- 17.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- low birth weight, fetal growth restriction, stroke mortality, coronary heart disease mortality, fetal programming, placental weight, head circumference, birth weight, child malnutrition
- MeSH terms
- Adult, Aged, Aged, 80 and over, Birth Weight, Cerebrovascular Disorders, Coronary Disease, England, Female, Embryonic and Fetal Development, Humans, Infant, Newborn, Male, Pelvis, Pregnancy, Risk Factors, Cohort Studies
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