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Cited by 3,574Birth, Development, and HealthHealthcare Systems and Public HealthMaternal and Neonatal Healthcare

WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE

Barker, D.J.P, Osmond, C, Winter, P.D, Margetts, B, Simmonds, S.J·1989·The Lancet
DOI 10.1016/s0140-6736(89)90710-1
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  • The DOHaD theory proposed that nutrient restriction during specific periods of development influences susceptibility for cardiovascular and metabolic diseases in adulthood.

    “Thus, the DOHaD theory proposed that nutrient restriction during specific periods of development (e.g., conception, gestation and the first few years of life), when tissues and organs are particularly sensitive to environmental exposures, as a consequence influence the susceptibility for cardiovascular and metabolic diseases in adulthood [41,42,43].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [43]

  • Babies born at the lower end of the birth weight scale (5 lb or 2.3 kg) had the highest adult mortality rates, while those at the opposite end (9 lb or 4.0 kg) were two-thirds lower.

    “Babies born at the lower end of the scale (5 lb or 2.3 kg) had the highest mortality rates as adults, while those at the opposite end (9 lb or 4.0 kg) were two-thirds lower.”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [40]

  • Barker and colleagues reported on approximately 15,000 records from men and women in Hertfordshire, UK, and showed that rates of death from ischemic heart disease were ordered across the birth weight scale.

    “In the late 1980s, they reported on ~15,000 records from men and women in Hertfordshire, UK, and showed that rates of death from ischemic heart disease were ordered across the birth weight scale (40).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [40]

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Authors
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J.
Affiliations
Southampton General Hospital (GB)
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1989-09
Volume
334
Issue
8663
Pages
577-580
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(89)90710-1
OpenAlex
W2079973462
Cited by
3,574
References
14
Citations by year
2026: 63 · 2025: 77 · 2024: 94 · 2023: 112 · 2022: 123 · 2021: 132 · 2020: 130 · 2019: 170 · 2018: 205 · 2017: 154 · 2016: 171 · 2015: 159 · 2014: 162 · 2013: 174 · 2012: 160
FWCI
43.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
infant weight, ischemic heart disease, mortality, birth weight, breastfeeding, fetal growth, postnatal growth, environmental influences on growth, cardiovascular risk factors
MeSH terms
Adult, Age Factors, Aged, Birth Weight, Body Weight, Bottle Feeding, Breast Feeding, Coronary Disease, England, Evaluation Studies as Topic, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Life Expectancy, Lung Diseases, Obstructive, Lung Neoplasms, Male, Middle Aged, Risk Factors, Social Class

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