Electroconvulsive stimuli alter nerve growth factor but not brain-derived neurotrophic factor concentrations in brains of a rat model of depression
Abstract
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system (CNS). Moreover, it has been hypothesized that these molecules play a role in the pathophysiology as well as treatment of depression. Using an animal model of depression, the Flinders Sensitive Line (FSL) rats and their controls, the Flinders Resistant Line (FRL), we investigated the effects of electroconvulsive stimuli (ECS) on brain NGF and BDNF. ECS or SHAM ECS were administered eight times, with a 48-h interval between each treatment. NGF and BDNF were measured with enzyme-linked immunosorbent assay (ELISA). In the hippocampus ECS increased NGF concentration in FSL but not FRL rats. ECS decreased NGF concentration in the frontal cortex of FSL rats. In both FSL and FRL rats ECS increased NGF levels in the striatum. In contrast, ECS did not change BDNF concentration in hippocampus, frontal cortex and striatum of FSL and FRL rats. Our data support the notion that neurotrophin concentrations may be altered by ECS.
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In the Flinders Sensitive Line rat model of depression, ECT increases NGF levels in the hippocampus.
“In the Flinders Sensitive Line (FSL) rat model of depression, ECT was found to increase NGF levels in the hippocampus (Angelucci et al. 2003a).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Angelucci et al. 2003a
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- Authors
- Angelucci, F., Aloe, L., Jiménez-Vasquez, P., & Mathé, A. A.
- Affiliations
- Karolinska Institutet (SE)
- Institute of Neurobiology and Molecular Medicine (IT)
- Corresponding author
- Mathé, Aleksander A.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 37
- Issue
- 1
- Pages
- 51-56
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2094555302
- Cited by
- 42
- References
- 35
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- electroconvulsive therapy, nerve growth factor, brain-derived neurotrophic factor, neurotrophins, depression, Flinders Sensitive Line rats, hippocampus, frontal cortex, striatum, rat model of depression
- MeSH terms
- Animals, Brain Chemistry, Depression, Electroshock, Enzyme-Linked Immunosorbent Assay, Male, Nerve Growth Factors, Rats, Inbred Strains, Brain-Derived Neurotrophic Factor, Rats
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