Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats

More hippocampal neurons in adult mice living in an enriched environment

Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,513 · see citing works

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works

The Nerve Growth Factor 35 Years Later

Levi‐Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,109 · see citing works

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150 · see citing works

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S., & Sapolsky, R. M. (1988) · Science · doi:10.1126/science.3340858 · Cited by 1,074 · see citing works

Physiological and behavioral effects of infantile stimulation

Levine, S., Haltmeyer, G. C., Karas, G. G., & Denenberg, V. H. (1967) · Physiology & Behavior · doi:10.1016/0031-9384(67)90011-x · Cited by 545 · see citing works

Neonatal Handling Alters Adrenocortical Negative Feedback Sensitivity and Hippocampal Type II Glucocorticoid Receptor Binding in the Rat

Meaney, M. J., Aitken, D. H., Viau, V., Sharma, S., & Sarrieau, A. (2008) · Neuroendocrinology · doi:10.1159/000125287 · Cited by 457 · see citing works

The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life

Meaney, M. J., Mitchell, J. B., Aitken, D. H., Bhatnagar, S., Bodnoff, S. R., Iny, L. J., & Sarrieau, A. (1991) · Psychoneuroendocrinology · doi:10.1016/0306-4530(91)90072-2 · Cited by 370 · see citing works

A critical period for social isolation in the rat

Einon, D. F., & Morgan, M. J. (1977) · Developmental Psychobiology · doi:10.1002/dev.420100205 · Cited by 342 · see citing works

Neonatal Handling and Environmental Enrichment Effects on Emotionality, Novelty/Reward Seeking, and Age-Related Cognitive and Hippocampal Impairments: Focus on the Roman Rat Lines

Fernández‐Teruel, A., Escorihuela, R. M., Castellano, B., González, B., & Tobeña, A. (1997) · Behavior Genetics · doi:10.1023/a:1021400830503 · Cited by 207 · see citing works

Environmental influences on the central nervous system and their implications for the aging rat

Mohammed, A. H. S., Henriksson, B. G., Söderström, S., Ebendal, T., Olsson, T., & Seckl, J. R. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90134-c · Cited by 204 · see citing works

Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo.

Neveu, I., & Arenas, E. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.3.631 · Cited by 201 · see citing works

Recovery from Brain Damage

Finger, S. (1978) · Springer eBooks · doi:10.1007/978-1-4615-7723-2 · Cited by 201 · see citing works

Early Experience Effects upon Cortical Dendrites: A Proposed Model for Development

Schapiro, S., & Vukovich, K. R. (1970) · Science · doi:10.1126/science.167.3916.292 · Cited by 180 · see citing works

Environments as Therapy for Brain Dysfunction

WALSH, R. N., & Greenough, W. T. (1976) · Advances in behavioral biology · doi:10.1007/978-1-4684-3081-3 · Cited by 180 · see citing works

Environmental influence on behaviour and nerve growth factor in the brain

Mohammed, A. K., Winblad, B. G., Ebendal, T., & Lärkfors, L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90195-h · Cited by 169 · see citing works

Environmentally-induced Changes in the Brains of Elderly Rats

Cummins, R. A., WALSH, R. N., Budtz‐Olsen, O. E., KONSTANTINOS, T., & HORSFALL, C. R. (1973) · Nature · doi:10.1038/243516a0 · Cited by 148 · see citing works

Response of the three main types of glial cells of cortex nad corpus callosum in rats handled during suckling or exposed to enriched, control and impoverished environments following weaning

Szeligo, F., & Leblond, C. P. (1977) · Journal of Comparative Neurology · doi:10.1002/cne.901720205 · Cited by 129 · see citing works

Effects of Postnatal Handling of Rats on Emotional, HPA-Axis, and Prolactin Reactivity to Novelty and Conflict

Núñez, J. F., Ferré, P., Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00225-9 · Cited by 127 · see citing works

Aspects of the Search for Neural Mechanisms of Memory

Rosenzweig, M. R. (1996) · Annual Review of Psychology · doi:10.1146/annurev.psych.47.1.1 · Cited by 125 · see citing works

Environmental Approaches to Recovery of Function from Brain Damage: A Review of Animal Studies (1981 to 1991)

Will, B. E., & Kelche, C. R. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3420-4_5 · Cited by 114 · see citing works

The Role of Early Environmental Events in Regulating Neuroendocrine Development: Moms, Pups, Stress, and Glucocorticoid Receptors

Francis, D. D., Diorio, J. C., LaPlante, P., Weaver, S., Seckl, J. R., & Meaney, M. J. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32517.x · Cited by 113 · see citing works

Effects of infantile handling on morphological development of the rat brain: An exploratory study

Altman, J., Das, G. D., & Anderson, W. J. (1968) · Developmental Psychobiology · doi:10.1002/dev.420010104 · Cited by 113 · see citing works

Environmental enrichment and postnatal handling prevent spatial learning deficits in aged hypoemotional (Roman high-avoidance) and hyperemotional (Roman low-avoidance) rats.Preprint

Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1995) · Learning & Memory · doi:10.1101/lm.2.1.40 · Cited by 104 · see citing works

Environmental enrichment reverses the detrimental action of early inconsistent stimulation and increases the beneficial effects of postnatal handling on shuttlebox learning in adult rats

Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90157-0 · Cited by 94 · see citing works

Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats

Henriksson, B. G., Söderström, S., Gower, A. J., Ebendal, T., Winblad, B. G., & Mohammed, A. H. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80134-2 · Cited by 91 · see citing works

Isolation has permanent effects upon the behavior of the rat, but not the mouse, gerbil, or guinea pig

Einon, D. F., Humphreys, A. P., Chivers, S. M., Field, S., & Naylor, V. (1981) · Developmental Psychobiology · doi:10.1002/dev.420140407 · Cited by 87 · see citing works

Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor

Pham, T. M., Söderström, S., Henriksson, B. G., & Mohammed, A. H. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02252-8 · Cited by 86 · see citing works

Effects of Postoperative Housing Conditions on Functional Recovery in Rats with Lesions of the Hippocampus, Subiculum, or Entorhinal Cortex

Galani, R., Jarrard, L. E., Will, B. E., & Kelche, C. R. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3745 · Cited by 86 · see citing works

Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions

Torasdotter, M., METSIS, M. L., Henriksson, B. G., Winblad, B. G., & Mohammed, A. H. S. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13127-x · Cited by 64 · see citing works

Recombinant human β‐nerve growth factor (NGF): Biological activity and properties in an enzyme immunoassay

Söderström, S., Hallböök, F., Ibáñez, C. F., Persson, H., & Ebendal, T. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270427 · Cited by 54 · see citing works

Environmental Therapy in Hypothyroid and Other Disadvantaged Animal Populations

Davenport, J. W. (1976) · Advances in behavioral biology · doi:10.1007/978-1-4684-3081-3_4 · Cited by 46 · see citing works

Exogenous Nerve Growth Factor Reverses Age‐Related Structural Changes in Neocortical Neurons in the Aging Rat

Mervis, R. F., POPE, D., LEWIS, R., Dvorak, R., & Williams, L. R. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00198.x · Cited by 46 · see citing works

Dexamethasone Induces Hypertrophy of Developing Medial Septum Cholinergic Neurons: Potential Role of Nerve Growth Factor

Shi, B., Rabin, S. J., Brandoli, C., & Mocchetti, I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09326.1998 · Cited by 28 · see citing works

How does environmental enrichment aid performance following cortical injury in the rat?

Rose, F. D., Davey, M. J., & Attree, E. A. (1993) · Neuroreport · doi:10.1097/00001756-199302000-00012 · Cited by 15 · see citing works

Individually housed rats exceed group-housed animals in rotational movements when exposed to a novel environment

Gentsch, C., Lichtsteiner, M., & Feer, H. (1983) · Cellular and Molecular Life Sciences · doi:10.1007/bf01990131 · Cited by 15 · see citing works

An active and socially integrated lifestyle in late life might protect against dementia

Fratiglioni, L., Paillard-Borg, S., & Winblad, B. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00767-7 · Cited by 2,135 · see citing works

Effects of environmental enrichment on gene expression in the brain

Rampon, C., Jiang, C. H., Dong, H., Tang, Y., Lockhart, D. J., Schultz, P. G., Tsien, J. Z., & Hu, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12880 · Cited by 614 · see citing works

Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways

Olson, A. K., Eadie, B. D., Ernst, C., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20157 · Cited by 565 · see citing works

Role of brain-derived neurotrophic factor in Huntington's disease

Zuccato, C., & Cattaneo, E. F. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.003 · Cited by 548 · see citing works

Brain reserve hypothesis in dementia

Fratiglioni, L., & Wang, H.-X. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-12103 · Cited by 499 · see citing works

Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms

Pryce, C. R., & Feldon, J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00009-5 · Cited by 460 · see citing works

High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children.

Buss, C., Davis, E. P., Muftuler, L. T., Head, K., & Sandman, C. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.010 · Cited by 435 · see citing works

The impact of environmental enrichment in laboratory rats—Behavioural and neurochemical aspects

Simpson, J., & Kelly, J. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.002 · Cited by 480 · see citing works

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367 · see citing works

Gray matter differences correlate with spontaneous strategies in a human virtual navigation task

Bohbot, V. D., Lerch, J., Thorndycraft, B., Iaria, G., & Zijdenbos, A. P. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1763-07.2007 · Cited by 347 · see citing works

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.004 · Cited by 288 · see citing works

Environmental enrichment and the brain

Mohammed, A. H., Zhu, S., Darmopil, S., Hjerling‐Leffler, J., Ernfors, P., Winblad, B. G., Diamond, M. C., Eriksson, P. S., & Bogdanović, N. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38074-9 · Cited by 267 · see citing works

Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington’s disease transgenic mice

Pang, T. Y. C., Stam, N. C., Nithianantharajah, J., Howard, M. L., & Hannan, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.013 · Cited by 265 · see citing works

Effects of Environmental Enrichment at Ages 3–5 Years on Schizotypal Personality and Antisocial Behavior at Ages 17 and 23 Years

Raine, A., Mellingen, K., Liu, J., Venables, P. H., & Mednick, S. A. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1627 · Cited by 263 · see citing works

Partial reversal of the effect of maternal care on cognitive function through environmental enrichment

Bredy, T. W., Humpartzoomian, R., Cain, D. P., & Meaney, M. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00918-1 · Cited by 248 · see citing works

The influences of environmental enrichment, cognitive enhancement, and physical exercise on brain development: Can we alter the developmental trajectory of ADHD?

Halperin, J. M., & Healey, D. M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.006 · Cited by 237 · see citing works

Psychological stress and environmental adaptation in enriched vs. impoverished housed rats

Larsson, F., Winblad, B. G., & Mohammed, A. H. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00782-7 · Cited by 205 · see citing works

Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression

Bredy, T. W., Zhang, T. Y., Grant, R. J., Diorio, J., & Meaney, M. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03599.x · Cited by 196 · see citing works

Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity

Williams, B. M., Luo, Y. M., Ward, C. P., Redd, K. J., Gibson, R., Kuczaj, S. A., & McCoy, J. G. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00543-1 · Cited by 191 · see citing works

Adolescent enrichment partially reverses the social isolation syndrome

Hellemans, K. G. C., Benge, L. C., & Olmstead, M. C. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.03.003 · Cited by 189 · see citing works

Environmental influences on brain neurotrophins in rats

Pham, T. M., Winblad, B. G., Granholm, A., & Mohammed, A. H. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00783-9 · Cited by 184 · see citing works

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186 · see citing works

Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study

Wang, H.-X., MacDonald, S., Dekhtyar, S., & Fratiglioni, L. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002251 · Cited by 170 · see citing works

Requirement of adult-born neurons for hippocampus-dependent learning

Marín‐Burgin, A., & Schinder, A. F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.001 · Cited by 174 · see citing works

Early-life handling stimulation and environmental enrichment

Fernández-Teruel, A., Giménez-Llort, L., Escorihuela, R. M., Gil, L., Aguilar, R., Steimer, T., & Tobeña, A. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00787-6 · Cited by 171 · see citing works

Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia

Gobbo, O. L., & O’Mara, S. M. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.017 · Cited by 170 · see citing works

Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner

Birch, A. M., McGarry, N., & Kelly, A. M. (2013) · Hippocampus · doi:10.1002/hipo.22103 · Cited by 161 · see citing works

Why is music therapeutic for neurological disorders? The Therapeutic Music Capacities Model

Brancatisano, O., Baird, A., & Thompson, W. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.008 · Cited by 167 · see citing works

Age-related deficits as working memory load increases: relationships with growth factors

Bimonte, H. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00015-5 · Cited by 150 · see citing works

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

Hu, Y.-S., Long, N., Pigino, G. F., Brady, S. T., & Lazarov, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064460 · Cited by 134 · see citing works

Epigenetic control of neurobehavioural plasticity: the role of neurotrophins

Branchi, I., Francia, N., & Alleva, E. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200409000-00006 · Cited by 133 · see citing works

Reviews: Mechanisms Mediating Brain Plasticity: IGF1 and Adult Hippocampal Neurogenesis

Llorens-Martı́n, M., Torres‐Alemán, I., & Trejo, J. L. (2009) · The Neuroscientist · doi:10.1177/1073858408331371 · Cited by 130 · see citing works

Long-term effects of the periadolescent environment on exploratory activity and aggressive behaviour in mice: social versus physical enrichment

Pietropaolo, S., Branchi, I., Cirulli, F., Chiarotti, F., Aloe, L., & Alleva, E. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.022 · Cited by 128 · see citing works

Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation

Fan, Y., Liu, Z., Weinstein, P. R., Fike, J. R., & Liu, J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05269.x · Cited by 117 · see citing works

The Effect of Enriched Environment on the Outcome of Traumatic Brain Injury; A Behavioral, Proteomics, and Histological Study

Kövesdi, E., Gyorgy, A. B., Kwon, S.-K. C., Wingo, D., Kamnaksh, A., Long, J. B., Kasper, C. E., & Agoston, D. V. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00042 · Cited by 114 · see citing works

Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats.

Peña, Y., Prunell, M., Rotllant, D., Armario, A., & Escorihuela, R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.019 · Cited by 117 · see citing works

Environmental enrichment enhances spatial cognition in rats by reducing thigmotaxis (wall hugging) during testing

Harris, A. P., D’Eath, R. B., & Healy, S. D. (2009) · Animal Behaviour · doi:10.1016/j.anbehav.2009.02.019 · Cited by 102 · see citing works

Environmental enrichment effects in social investigation in rats are gender dependent

Peña-López, Y., Prunell, M., DIMITSANTOS, V., Nadal, R. A., & Escorihuela, R. M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.007 · Cited by 102 · see citing works

Combined pre- and postnatal environmental enrichment programs the HPA axis differentially in male and female rats

Welberg, L., Thrivikraman, K. V., & Plotsky, P. M. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.11.011 · Cited by 98 · see citing works

Sex differences in object location memory and spatial navigation in Long-Evans rats

Saucier, D. M., Shultz, S. R., Keller, A. J., Cook, C. M., & Binsted, G. (2007) · Animal Cognition · doi:10.1007/s10071-007-0096-1 · Cited by 98 · see citing works

Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner

Bakoš, J., Hlaváčová, N., Rajman, M., Ondičová, K., Koros, C., Kitraki, E., Steinbusch, H. W. M., & Ježová, D. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.054 · Cited by 96 · see citing works

Transformation of cortical and hippocampal neural circuit by environmental enrichment

Hirase, H., & Shinohara, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.031 · Cited by 91 · see citing works

Huntington’s Disease

Zuccato, C., & Cattaneo, E. F. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-45106-5_14 · Cited by 92 · see citing works

Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour

Tanimura, Y., Yang, M. C. K., & Lewis, M. H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.001 · Cited by 90 · see citing works

Broad activation of the olfactory bulb produces long-lasting changes in odor perception

Mandairon, N., Stack, C. M., Kiselycznyk, C., & Linster, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602750103 · Cited by 89 · see citing works

A “deficient environment” in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus

Gómez‐Pinilla, F., & Vaynman, S. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.12.001 · Cited by 88 · see citing works

Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment

Angelucci, F., Bartolo, P. D., Gelfo, F., Foti, F., Cutuli, D., Bossù, P., Caltagirone, C., & Petrosini, L. (2009) · The Cerebellum · doi:10.1007/s12311-009-0129-1 · Cited by 88 · see citing works

Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats

Sandstrom, N. J., Loy, R., & Williams, C. L. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02900-1 · Cited by 87 · see citing works

Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats

Grimm, J. W., Osincup, D., Wells, B., Manaois, M., Fyall, A., Buse, C., & Harkness, J. H. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32831c3b18 · Cited by 85 · see citing works

Voluntary exercise influences behavioral development in rats exposed to alcohol during the neonatal brain growth spurt.

Thomas, J. D., Sather, T., & Whinery, L. A. (2008) · Behavioral Neuroscience · doi:10.1037/a0013271 · Cited by 85 · see citing works

Predicting long-term outcome following traumatic brain injury (TBI)

Rassovsky, Y., Levi, Y., Agranov, E., Sela-Kaufman, M., Sverdlik, A., & Vakil, E. (2015) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1015498 · Cited by 81 · see citing works

Spatio‐temporal activation of cyclic AMP response element‐binding protein, activity‐regulated cytoskeletal‐associated protein and brain‐derived nerve growth factor: a mechanism for pontine‐wave generator activation‐dependent two‐way active‐avoidance memory processing in the rat

Ulloor, J., & Datta, S. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03378.x · Cited by 89 · see citing works

Enriched environment effects on behavior, memory and BDNF in low and high exploratory mice

Kazlauckas, V., Pagnussat, N., Mioranzza, S., Kalinine, E., Nunes, F., Pettenuzzo, L. F., Souza, D. O., Portela, L. V., Porciúncula, L. O., & Lara, D. R. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.025 · Cited by 75 · see citing works

Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding

Hellemans, K. G. C., Nóbrega, J. N., & Olmstead, M. C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.10.018 · Cited by 75 · see citing works

Elevation of Nerve Growth Factor and Antisense Knockdown of TrkA Receptor during Contextual Memory Consolidation

Woolf, N. J., Milov, A. M., Schweitzer, E. S., & Roghani, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-01047.2001 · Cited by 68 · see citing works

The Interaction between Psychological Health and Traumatic Brain Injury: A Neuroscience perspective

Hoffman, S. W., & Harrison, C. R. (2009) · The Clinical Neuropsychologist · doi:10.1080/13854040903369433 · Cited by 65 · see citing works

Selective Nicotinic Receptor Consequences in APPSWE Transgenic Mice

Bednar, I., Paterson, D., Marutle, A., Pham, T. M., Svedberg, M. M., Hellström‐Lindahl, E., Mousavi, M. T., COURT, J. A., Morris, C. M., Perry, E. K., et al. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1112 · Cited by 65 · see citing works

Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairmentPreprint

Hellweg, R., Lohmann, P., Huber, R., Kühl, A., & Riepe, M. W. (2006) · Learning & Memory · doi:10.1101/lm.2606 · Cited by 63 · see citing works

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study

Ledreux, A., Håkansson, K., Carlsson, R., Kidane, M., Columbo, L., Terjestam, Y., Ryan, E., Tusch, E. S., Winblad, B. G., Daffner, K. R., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190756 · Cited by 60 · see citing works

Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice

Zhu, S., Codita, A., Bogdanović, N., Hjerling‐Leffler, J., Ernfors, P., Winblad, B. G., Dickins, D. W., & Mohammed, A. H. S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.032 · Cited by 58 · see citing works

Effects of Enriched Physical and Social Environments on Motor Performance, Associative Learning, and Hippocampal Neurogenesis in Mice

Madroñal, N., López-Aracil, C., Rangel, A., del Rı́o, J. A., Delgado-Garcia, J. M., & Gruart, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011130 · Cited by 58 · see citing works

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Holguin, S., Huang, Y., Liu, J., & Wurtman, R. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.042 · Cited by 57 · see citing works

Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?

Dhanushkodi, A., & Shetty, A. K. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.004 · Cited by 55 · see citing works

Tactile stimulation and maternal separation prevent hippocampal damage in rats submitted to neonatal hypoxia–ischemia

Rodrigues, A. L., Arteni, N. S., Abel, C. R., Zylbersztejn, D. S., Chazan, R., Viola, G. G., Xavier, L. L., Achaval, M., & Netto, C. A. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.020 · Cited by 54 · see citing works

Environmental change during postnatal development alters behaviour, cognitions and neurogenesis of mice

Iso, H., Shimoda, S., & Matsuyama, T. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.025 · Cited by 52 · see citing works

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

Liew, A., Teo, C. H., & Soga, T. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03016-w · Cited by 41 · see citing works

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan

Fréret, T., Billard, J., Schumann‐Bard, P., Dutar, P., Dauphin, F., Boulouard, M., & Bouët, V. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.028 · Cited by 52 · see citing works

Behavioral/Environmental Intervention Improves Learning After Cerebral Hypoxia-Ischemia in Rats

Chou, I., Trakht, T., Signori, C., Smith, J., Felt, B. T., Vázquez, D. M., & Barks, J. (2001) · Stroke · doi:10.1161/hs0901.095656 · Cited by 51 · see citing works

Alzheimer’s Disease, Neural Plasticity, and Functional Recovery

Mercerón‐Martínez, D., Ibaceta-González, C., Salazar, C., Almaguer‐Melian, W., Bergado, J. A., & Palacios, A. G. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201178 · Cited by 48 · see citing works

Influence of environmental enrichment on steady-state mRNA levels for EAAC1, AMPA1 and NMDA2A receptor subunits in rat hippocampus

Andin, J., Hallbeck, M., Mohammed, A. H. S., & Marcusson, J. O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.101 · Cited by 48 · see citing works

Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring

Sparling, J. E., Baker, S. L., & Bielajew, C. H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.033 · Cited by 47 · see citing works

Handling and environmental enrichment do not rescue learning and memory impairments in αCamKIIT286A mutant mice

Need, A. C., & Giese, K.-P. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00020.x · Cited by 47 · see citing works

Exposure to enriched environment improves spatial learning performances and enhances cell density but not choline acetyltransferase activity in the hippocampus of ventral subicular-lesioned rats.

Dhanushkodi, A., Bindu, B., Raju, T. R., & Kutty, B. M. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.491 · Cited by 44 · see citing works

System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment

Bonaccorsi, J., Cintoli, S., Mastrogiacomo, R., Baldanzi, S., Braschi, C., Pizzorusso, T., Cenni, M. C., & Berardi, N. (2013) · Neural Plasticity · doi:10.1155/2013/956312 · Cited by 43 · see citing works

Electroconvulsive stimuli alter nerve growth factor but not brain-derived neurotrophic factor concentrations in brains of a rat model of depression

Angelucci, F., Aloe, L., Jiménez-Vasquez, P., & Mathé, A. A. (2003) · Neuropeptides · doi:10.1016/s0143-4179(03)00004-0 · Cited by 42 · see citing works

Effects of cafeteria diet and high fat diet intake on anxiety, learning and memory in adult male rats

Pini, R. T. B., do Vales, L. D. M. F., Costa, T. M. B., & Almeida, S. S. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1149294 · Cited by 40 · see citing works

Environmental enrichment and its influence on rodent offspring and maternal behaviours, a scoping style review of indices of depression and anxiety

Sparling, J. E., Barbeau, K., Boileau, K., & Konkle, A. T. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172997 · Cited by 40 · see citing works

Enriched environment exposure alters the input-output dynamics of synaptic transmission in area CA1 of freely moving rats

Irvine, G. I., & Abraham, W. C. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.031 · Cited by 40 · see citing works

The impact of environmental and social factors on learning abilities: a meta‐analysis

Lambert, C. T., & Guillette, L. M. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12783 · Cited by 39 · see citing works

Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats

Bindu, B., Jagadapillai, R., & Kutty, B. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.044 · Cited by 37 · see citing works

Early environmental therapy rescues brain development in a mouse model of Down syndrome

Begenisic, T., Sansevero, G., Baroncelli, L., Cioni, G., & Sale, A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.07.014 · Cited by 34 · see citing works

The effects of gestational and postpartum environmental enrichment on the mother rat: A preliminary investigation

Sparling, J. E., Mahoney, M. M., Baker, S., & Bielajew, C. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.041 · Cited by 35 · see citing works

Early environmental cues affect object recognition memory in adult female but not male C57BL/6 mice

Coutellier, L. D., & Würbel, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.001 · Cited by 34 · see citing works

Influence of environmental enrichment on an object recognition task in CF1 mice

Viola, G. G., Botton, P. H. S., Moreira, J. D., Ardais, A. P., Oses, J. P., & Souza, D. O. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.10.003 · Cited by 34 · see citing works

The role of cognitive activity in cognition protection: from Bedside to Bench

Li, B., Wang, Y., Tang, H., & Chen, S. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0078-4 · Cited by 32 · see citing works

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

O’Connor, A. M., Burton, T. J., Leamey, C. A., & Sawatari, A. (2014) · Journal of Visualized Experiments · doi:10.3791/52225 · Cited by 30 · see citing works

Early experience and domestication affect auditory discrimination learning, open field behaviour and brain size in wild Mongolian gerbils and domesticated Laboratory gerbils (Meriones unguiculatus forma domestica)

Stuermer, I. W., & Wetzel, W. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.025 · Cited by 30 · see citing works

Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood

Aghaie, C. I., Hausknecht, K. A., Wang, R., Dezfuli, P. H., Haj‐Dahmane, S., Kane, C. J. M., Sigurdson, W. J., & Shen, R. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14275 · Cited by 29 · see citing works

Sleeping Together

Donlea, J. M., & Shaw, P. J. (2009) · Advances in genetics · doi:10.1016/s0065-2660(09)68003-2 · Cited by 29 · see citing works

Early environment contributes to developmental disruption of MPFC after neonatal ventral hippocampal lesions in rats

Wood, G. K., Quirion, R., & Srivastava, L. K. (2003) · Synapse · doi:10.1002/syn.10265 · Cited by 29 · see citing works

Impact of Dementia‐derived Nonpharmacological Intervention Procedures on Cognition and Behavior in Older Adults With Intellectual Disabilities: A 3‐year Follow‐up Study

Vreese, L. P. D., Mantesso, U., Bastiani, E. D., Weger, E., Marangoni, A., & Gomiero, T. (2012) · Journal of Policy and Practice in Intellectual Disabilities · doi:10.1111/j.1741-1130.2012.00344.x · Cited by 28 · see citing works

Exposure to a broad range of odorants decreases cell mortality in the olfactory bulb

Woo, C. C., Hingco, E. E., Taylor, G. E., & Leon, M. (2006) · Neuroreport · doi:10.1097/01.wnr.0000215780.84226.2d · Cited by 28 · see citing works

Modest environmental enrichment: Effect on a radial maze validation and well being of rats

Brillaud, E., Morillion, D., & de Sèze, R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.069 · Cited by 28 · see citing works

Neonatal Handling Impairs Spatial Memory and Leads to Altered Nitric Oxide Production and DNA Breaks in A Sex Specific Manner

Noschang, C. G., Krolow, R., Fontella, F. U., Arcego, D. M., Diehl, L. A., Weis, S. N., Arteni, N. S., & Dalmaz, C. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0158-7 · Cited by 27 · see citing works

Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure

Wang, R., Hausknecht, K. A., Shen, Y.-L., Haj‐Dahmane, S., Vezina, P., & Shen, R. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.07.013 · Cited by 27 · see citing works

Enriched Environment and White Matter in Aging Brain

Yang, S., Lü, W., Zhou, D., & Tang, Y. C. (2012) · The Anatomical Record · doi:10.1002/ar.22526 · Cited by 27 · see citing works

Abilities in tactile discrimination of textures in adult rats exposed to enriched or impoverished environments

Bourgeon, S., Xerri, C., & Coq, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.002 · Cited by 26 · see citing works

Effects of Postnatal Cocaine Exposure and Environmental Enrichment on Rat Behavior in a Forced Swim Test

Magalhães, A., Summavielle, T., Ferreira, M. A., & de Sousa, L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.077 · Cited by 24 · see citing works

Tactile stimulation and neonatal isolation affect behavior and oxidative status linked to cocaine administration in young rats

Antoniazzi, C. T. D. D., Boufleur, N., Pase, C. S., Kuhn, F. T., Dias, V. T., Segat, H. J., Roversi, K., Roversi, K., Benvegnú, D. M., & Bürger, M. E. (2014) · Behavioural Processes · doi:10.1016/j.beproc.2014.01.011 · Cited by 23 · see citing works

Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat

Simpson, J., Bree, D., & Kelly, J. P. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.008 · Cited by 23 · see citing works

Effects of neonatal handling and enriched environment on neurotrophins and cognitive function

Pham, T. M. (2000) · Figshare

Environmental influence on behaviour and nerve growth factor in the brain

Mohammed, A. K., Winblad, B. G., Ebendal, T., & Lärkfors, L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90195-h · Cited by 169 · see citing works

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

Pham, T. M., Ickes, B. R., Albeck, D. S., Söderström, S., Granholm, A.-C., & Mohammed, A. H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00316-4 · Cited by 262 · see citing works

Environmental enrichment increases NGF levels in hippocampus and visual cortex and improves spatial learning in elderly rats

Pham, T., Söderström, S., Bogdanović, N., Henriksson, B. G., Winblad, B. G., & Mohammed, A. H. (1997) · Acta Neurobiologiae Experimentalis · Cited by 1 · see citing works

Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner

Birch, A. M., McGarry, N., & Kelly, A. M. (2013) · Hippocampus · doi:10.1002/hipo.22103 · Cited by 161 · see citing works