Cited by 90Congenital heart defects researchCardiac Ischemia and ReperfusionCardiovascular Function and Risk Factors

Substrate metabolism in the developing heart

Ascuitto, Robert J., Ross-Ascuitto, Nancy T.·1996·Seminars in Perinatology

Abstract

The developing heart undergoes a remarkable metabolic transformation as it adjusts to the higher-oxygen, extrauterine environment. During gestation, glycolysis and lactate oxidation constitute the major sources of adenosine triphosphate (ATP) for the fetal heart. After birth, however, there is a rapid shift from carbohydrate to fatty acid utilization. Despite the transition to primarily aerobic metabolism, the neonatal heart retains an enhanced capacity for anaerobic energy production. This unique metabolic adaptation is important when assessing the immature heart's responses to states of oxygen insufficiency, such as ischemia, hypoxia, and tachycardia. This article reviews the dramatic changes in enzyme activities, mitochondrial morphology and function, and substrate availability that underlie this change in metabolism in the maturing heart.

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Crossref · 10.1016/s0146-0005(96)80068-1

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145 of 145 references verified0 citation errors · 0 not checkable

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Authors
Ascuitto, R. J., & Ross-Ascuitto, N. T.
Affiliations
Tulane University (US)
Corresponding author
Ascuitto, Robert J.
Venue
Seminars in Perinatology
Publisher
Elsevier BV
Published
1996-12
Volume
20
Issue
6
Pages
542-563
ISSN
0146-0005 (ISSN-L)
OpenAlex
W1982446540
Cited by
90
References
146
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 6 · 2016: 5 · 2015: 1 · 2014: 9 · 2013: 6 · 2012: 1
FWCI
0.10
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Perinatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29hl045603-04)
  • National Heart, Lung, and Blood Institute (HL-45603)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
fetal heart, neonatal heart, cardiac substrate metabolism, glycolysis, lactate oxidation, fatty acid oxidation, aerobic metabolism, anaerobic energy production, mitochondrial function, mitochondrial morphology, hypoxia, myocardial ischemia, tachycardia
MeSH terms
Adenosine Triphosphate, Animals, Energy Metabolism, Fatty Acids, Glycolysis, Heart, Heart Diseases, Humans, Myocardium, Lactic Acid

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