Substrate metabolism in the developing heart
Abstract
The developing heart undergoes a remarkable metabolic transformation as it adjusts to the higher-oxygen, extrauterine environment. During gestation, glycolysis and lactate oxidation constitute the major sources of adenosine triphosphate (ATP) for the fetal heart. After birth, however, there is a rapid shift from carbohydrate to fatty acid utilization. Despite the transition to primarily aerobic metabolism, the neonatal heart retains an enhanced capacity for anaerobic energy production. This unique metabolic adaptation is important when assessing the immature heart's responses to states of oxygen insufficiency, such as ischemia, hypoxia, and tachycardia. This article reviews the dramatic changes in enzyme activities, mitochondrial morphology and function, and substrate availability that underlie this change in metabolism in the maturing heart.
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Ultrasound examination of the fetal coronary circulation
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- Authors
- Ascuitto, R. J., & Ross-Ascuitto, N. T.
- Affiliations
- Tulane University (US)
- Corresponding author
- Ascuitto, Robert J.
- ORCID
- Ascuitto, Robert J.
- Venue
- Seminars in Perinatology
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 20
- Issue
- 6
- Pages
- 542-563
- ISSN
- 0146-0005 (ISSN-L)
- OpenAlex
- W1982446540
- Cited by
- 90
- References
- 146
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 6 · 2016: 5 · 2015: 1 · 2014: 9 · 2013: 6 · 2012: 1
- FWCI
- 0.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29hl045603-04)
- National Heart, Lung, and Blood Institute (HL-45603)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- fetal heart, neonatal heart, cardiac substrate metabolism, glycolysis, lactate oxidation, fatty acid oxidation, aerobic metabolism, anaerobic energy production, mitochondrial function, mitochondrial morphology, hypoxia, myocardial ischemia, tachycardia
- MeSH terms
- Adenosine Triphosphate, Animals, Energy Metabolism, Fatty Acids, Glycolysis, Heart, Heart Diseases, Humans, Myocardium, Lactic Acid
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