Methods for explaining the clinical significance of health status measures
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Interventions can have clinical importance despite not reaching statistical significance, and aspects such as data variability and sample size may influence statistical results.
“Interventions can also have clinical importance despite not reaching statistical significance, and aspects such as data variability and sample size may influence statistical results [56].”
From Short-Term Findings From Testing EPIO, a Digital Self-Management Program for People Living With Chronic Pain: Randomized Controlled Trial (2023) · cites this paper as [56]
Cites
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,415 · see citing works
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,414 · see citing works
Jaeschke, R., Singer, J., & Guyatt, G. H. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90005-6 · Cited by 4,982 · see citing works
Self-citationThe Sickness Impact Profile: Development and Final Revision of a Health Status Measure
Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981) · Medical Care · doi:10.1097/00005650-198108000-00001 · Cited by 4,619 · see citing works
Interpreting the significance of changes in health-related quality-of-life scores.
Osoba, D., Rodrigues, G., Myles, J., Zee, B. C.-Y., & Pater, J. L. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.1.139 · Cited by 3,013 · see citing works
Self-citationEffect Sizes for Interpreting Changes in Health Status
Kazis, L. E., Anderson, J. J., & Meenan, R. F. (1989) · Medical Care · doi:10.1097/00005650-198903001-00015 · Cited by 2,401 · see citing works
Individual-patient monitoring in clinical practice: are available health status surveys adequate?
McHorney, C. A., & Tarlov, A. R. (1995) · Quality of Life Research · doi:10.1007/bf01593882 · Cited by 2,206 · see citing works
Measuring Health-Related Quality of Life
Guyatt, G., Feeny, D., & Patrick, D. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-8-199304150-00009 · Cited by 2,168 · see citing works
Self-citationSelf-rated health: a predictor of mortality among the elderly.
Mossey, J. M., & Shapiro, E. (1982) · American Journal of Public Health · doi:10.2105/ajph.72.8.800 · Cited by 2,145 · see citing works
Determining a minimal important change in a disease-specific quality of life questionnaire
JUNIPER, E. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90036-1 · Cited by 1,824 · see citing works
A measure of quality of life for clinical trials in chronic lung disease
Guyatt, G. H., Berman, L. B., Townsend, M., Pugsley, S. O., & Chambers, L. W. (1987) · Thorax · doi:10.1136/thx.42.10.773 · Cited by 1,721 · see citing works
Self-citationThrombolysis for acute ischaemic stroke
Wardlaw, J. M., Murray, V., Berge, E., & del Zoppo, G. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000213.pub3 · Cited by 1,460 · see citing works
Measuring quality of life in children with asthma
Juniper, E. F., Guyatt, G. H., Feeny, D. H., Ferrie, P. J., Griffith, L. E., & Townsend, M. (1996) · Quality of Life Research · doi:10.1007/bf00435967 · Cited by 1,169 · see citing works
Self-citationRedelmeier, D. A., Bayoumi, A. M., Goldstein, R. S., & Guyatt, G. H. (1997) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.155.4.9105067 · Cited by 1,029 · see citing works
Self-citationGoldman, L., Hashimoto, B. E., Cook, E. F., & Loscalzo, A. (1981) · Circulation · doi:10.1161/01.cir.64.6.1227 · Cited by 976 · see citing works
Determining Clinically Important Differences in Health Status Measures
Samsa, G., Edelman, D. E., Rothman, M. L., Williams, G. R., Lipscomb, J., & Matchar, D. B. (1999) · PharmacoEconomics · doi:10.2165/00019053-199915020-00003 · Cited by 917 · see citing works
Decision aids for patients facing health treatment or screening decisions: systematic review
O'Connor, A. M. C., Rostom, A., Fiset, V., Tetroe, J., Entwistle, V. A., Llewellyn-Thomas, H. A., Holmes-Rovner, M. M., Barry, M. J., & Jones, J. A. (1999) · BMJ · doi:10.1136/bmj.319.7212.731 · Cited by 862 · see citing works
Wyrwich, K. W., Tierney, W. M., & Wolinsky, F. D. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00071-2 · Cited by 858 · see citing works
Self-citationJacobson, N. S., Roberts, L. J., Berns, S. B., & McGlinchey, J. B. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.67.3.300 · Cited by 853 · see citing works
Jacobson, N. S., Roberts, L. J., Berns, S. B., & McGlinchey, J. B. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.3.300 · Cited by 853 · see citing works
Deyo, R. A., & Centor, R. M. (1986) · Journal of Chronic Diseases · doi:10.1016/0021-9681(86)90038-x · Cited by 800 · see citing works
Does Free Care Improve Adults' Health?
Brook, R. H., Ware, J. E., Rogers, W. H., Keeler, E. B., Davies, A. R., Donald, C. A., Goldberg, G. A., Lohr, K. N., Masthay, P. C., & Newhouse, J. P. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312083092305 · Cited by 666 · see citing works
The interpretation of scores from the EORTC quality of life questionnaire QLQ-C30
King, M. T. (1996) · Quality of Life Research · doi:10.1007/bf00439229 · Cited by 666 · see citing works
Wyrwich, K. W., Nienaber, N. A., Tierney, W. M., & Wolinsky, F. D. (1999) · Medical Care · doi:10.1097/00005650-199905000-00006 · Cited by 567 · see citing works
Self-citationInterpretation of quality of life changes
LYDICK, E. G., & Epstein, R. S. (1993) · Quality of Life Research · doi:10.1007/bf00435226 · Cited by 531 · see citing works
Norman, G. R., Stratford, P. W., & Regehr, G. (1997) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00097-8 · Cited by 524 · see citing works
Self-citationInterpreting treatment effects in randomised trials
Guyatt, G. H., Juniper, E. F., Walter, S. D., Griffith, L. E., & Goldstein, R. S. (1998) · BMJ · doi:10.1136/bmj.316.7132.690 · Cited by 516 · see citing works
Self-citationLife quality of patients with chronic obstructive pulmonary disease
McSweeny, A. J. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340160057014 · Cited by 490 · see citing works
Normative comparisons for the evaluation of clinical significance.
Kendall, P. C., Marrs, A. L., Nath, S. R., & Sheldrick, R. C. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.67.3.285 · Cited by 468 · see citing works
The Clinical Meaning of Rankin ‘Handicap’ Grades After Stroke
de Haan, R. J., Limburg, M., Bossuyt, P. M., van der Meulen, J., & Aaronson, N. K. (1995) · Stroke · doi:10.1161/01.str.26.11.2027 · Cited by 450 · see citing works
Sensitivity to Change of the Roland-Morris Back Pain Questionnaire: Part 1
Stratford, P. W., Binkley, J. M., Riddle, D. L., & Guyatt, G. H. (1998) · Physical Therapy · doi:10.1093/ptj/78.11.1186 · Cited by 427 · see citing works
Self-citationNaylor, C., Chen, E., & Strauss, B. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-11-916 · Cited by 392 · see citing works
Assessing the minimal important difference in symptoms: A comparison of two techniques
Redelmeier, D. A., Guyatt, G. H., & Goldstein, R. S. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00206-5 · Cited by 375 · see citing works
Self-citationDevelopment and testing of a new measure of health status for clinical trials in heart failure
Guyatt, G. H., Nogradi, S., Halcrow, S., Singer, J., Sullivan, M. J., & Fallen, E. L. (1989) · Journal of General Internal Medicine · doi:10.1007/bf02602348 · Cited by 336 · see citing works
Self-citationSensitivity to Change of the Roland-Morris Back Pain Questionnaire: Part 2
Riddle, D. L., Stratford, P. W., & Binkley, J. M. (1998) · Physical Therapy · doi:10.1093/ptj/78.11.1197 · Cited by 278 · see citing works
What are minimal important changes for asthma measures in a clinical trial?
Santanello, N. C., Zhang, J., Seidenberg, B. C., Reiss, T. F., & Barber, B. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14a06.x · Cited by 276 · see citing works
Quality of Life and Antihypertensive Therapy in Men -- A Comparison of Captopril with Enalapril
Testa, M. A., Anderson, R. B., Nackley, J. F., & Hollenberg, N. K. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304013281302 · Cited by 262 · see citing works
Norman, G. R., Gwadry-Sridhar, F. H., Guyatt, G. H., & Walter, S. D. (2001) · Medical Care · doi:10.1097/00005650-200110000-00002 · Cited by 260 · see citing works
Self-citationInterpretation of rhinoconjunctivitis quality of life questionnaire data
Juniper, E. F., Guyatt, G. H., Griffith, L. E., & Ferrie, P. J. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)70135-5 · Cited by 243 · see citing works
Self-citationKravitz, R. L. (1992) · JAMA · doi:10.1001/jama.267.12.1617 · Cited by 243 · see citing works
Discrepancy between Medical Decisions for Individual Patients and for Groups
Redelmeier, D. A., & Tversky, A. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004193221620 · Cited by 241 · see citing works
Identifying meaningful intra‐individual change standards for health‐related quality of life measures
Wyrwich, K. W., & Wolinsky, F. D. (2000) · Journal of Evaluation in Clinical Practice · doi:10.1046/j.1365-2753.2000.00238.x · Cited by 226 · see citing works
Self-citationOsoba, D., Tannock, I. F., Ernst, D. S., & Neville, A. J. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.6.1654 · Cited by 224 · see citing works
Self-citationOsoba, D., Brada, M., Yung, W. K. A., & Prados, M. D. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.7.1481 · Cited by 209 · see citing works
Self-citationCompleteness of reporting trial results: effect on physicians' willingness to prescribe.
Bobbio, M., Demichelis, B., & Giustetto, G. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92407-4 · Cited by 196 · see citing works
Assessing the Clinical Importance of Symptomatic Improvements
Redelmeier, D. A. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.11.1337 · Cited by 184 · see citing works
Users' Guides to the Medical Literature XVI. How to Use a Treatment Recommendation
Guyatt, G. H. (1999) · JAMA · doi:10.1001/jama.281.19.1836 · Cited by 182 · see citing works
Self-citationDeyo, R. A., Inui, T. S., Leininger, J. D., & Overman, S. S. (1983) · Medical Care · doi:10.1097/00005650-198302000-00006 · Cited by 158 · see citing works
Deyo, R. A. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.142.5.879 · Cited by 140 · see citing works
Economic Analysis of Respiratory Rehabilitation
Goldstein, R. S., Gort, E. H., Guyatt, G. H., & Feeny, D. H. (1997) · CHEST Journal · doi:10.1378/chest.112.2.370 · Cited by 128 · see citing works
Self-citationInterpretation of Quality-of-Life Outcomes
Testa, M. A. (2000) · Medical Care · doi:10.1097/00005650-200009002-00026 · Cited by 110 · see citing works
Setting the minimal metrically detectable change on disability rating scales
Hébert, R., Spiegelhalter, D. J., & Brayne, C. (1997) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(97)90301-4 · Cited by 110 · see citing works
Fletcher, A., McLoone, P., & Bulpitt, C. J. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92942-x · Cited by 94 · see citing works
The cost effectiveness of auranofin: results of a randomized clinical trial.
Ms, T., Jl, R., Hutchings, H. C., Paterson, M. E. L., & Harris, E. D. (1988) · PubMed · Cited by 86 · see citing works
The Impact of Psychologic Factors on Measurement of Functional Status
Brooks, W. B., Jordan, J. S., Divine, G., Smith, K. S., & Neelon, F. A. (1990) · Medical Care · doi:10.1097/00005650-199009000-00009 · Cited by 82 · see citing works
Roberts, C. (1999) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19991015)18:19 · Cited by 79 · see citing works
Naylor, C. D., & Llewellyn‐Thomas, H. A. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90176-7 · Cited by 75 · see citing works
The significance of treatment effects: the clinical perspective.
Ra, D., & Dl, P. (1995) · PubMed · Cited by 59 · see citing works
Ward, M. M., Marx, A. S., & Barry, N. N. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00140-7 · Cited by 44 · see citing works
Impact of the global on patient perceivable change in an asthma specific QOL questionnaire
Barber, B., Santanello, N. C., & Epstein, R. S. (1996) · Quality of Life Research · doi:10.1007/bf00435976 · Cited by 42 · see citing works
Hux, J. E., Levinton, C. M., & Naylor, C. D. (1994) · Journal of General Internal Medicine · doi:10.1007/bf02600123 · Cited by 38 · see citing works
On the debate over methods for estimating the clinically important difference
Redelmeier, D. A., Guyatt, G. H., & Goldstein, R. S. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00208-9 · Cited by 33 · see citing works
Self-citationInterpreting Pharmacoeconomic and Quality-of-Life Clinical Trial Data for Use in Therapeutics
Testa, M. A., & Lenderking, W. R. (1992) · PharmacoEconomics · doi:10.2165/00019053-199202020-00004 · Cited by 33 · see citing works
The Crohn’s Disease Activity Index as a Clinical Instrument
Best, W. R., & Becktel, J. M. (1981) · Springer eBooks · doi:10.1007/978-94-009-8273-4_2 · Cited by 32 · see citing works
Estimating the number needed to treat (NNT) index when the data are subject to error
Walter, S. D., & Irwig, L. (2001) · Statistics in Medicine · doi:10.1002/sim.707 · Cited by 26 · see citing works
Response to Testa: Approaches to the Interpretation of Quality-of-Life Scales
LYDICK, E. G. (2000) · Medical Care · doi:10.1097/00005650-200009002-00028 · Cited by 24 · see citing works
Norman, G. R., Gwadry-Sridhar, F., Guyatt, G., & Walter, S. (2001) · Value in Health · doi:10.1016/s1098-3015(11)71558-3 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Nasrallah, H., Morosini, P., & Gagnon, D. D. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.11.012 · Cited by 243 · see citing works
Bostrøm, K., Børøsund, E., Eide, H., Varsi, C., Kristjansdottir, Ó. B., Schreurs, K. M. G., Waxenberg, L. B., Weiss, K. E., Morrison, E. J., Stavenes Støle, H., et al. (2023) · Journal of Medical Internet Research · doi:10.2196/47284 · Cited by 12 · see citing works
“Interventions can also have clinical importance despite not reaching statistical significance, and aspects such as data variability and sample size may influence statistical results [56].”
- Authors
- Guyatt, G., Osoba, D., Wu, A., Wyrwich, K., & Norman, G.
- Affiliations
- McMaster University (CA)
- Johns Hopkins University (US)
- Venue
- Clinical Therapeutics
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 24
- Pages
- 5
- ISSN
- 0149-2918 (ISSN-L)
- OpenAlex
- W2169780156
- Cited by
- 10
- References
- 67
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2015: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Therapeutics (publishedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Social Sciences › Education › Health Education and Validation
- Keywords
- health indicators, quality of life instruments, interpretability, anchor-based methods, distribution-based methods, minimal clinically important difference, criterion validation, construct validation, standard error of measurement, clinical significance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
