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Cognitive effects of insulin in the central nervous system
Abstract
Evidence has been accumulating recently that the hormone insulin may modulate cognitive activity by acting in the central nervous system. Initially derived from the observation that insulin and insulin receptors are found in specific brain areas, this evidence also includes cognitive assessments of humans in insulin-deficient and insulin-resistant disease states and experimental manipulation of rodent models. Additional support is derived from in vivo and in vitro systems that are used to investigate the neurophysiological basis of learning and memory. This article is a brief review of the literature that suggests a connection between insulin and memory and draws together some of the findings relevant to possible physiological mechanisms for this cognitive effect.
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“the risk of the metabolic syndrome[76]”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [76]
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Metadata
- Authors
- Park, C. R.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Park, C.R
- ORCID
- Park, C.R
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 25
- Issue
- 4
- Pages
- 311-323
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2013952491
- Cited by
- 270
- References
- 206
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 13 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 12
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- insulin, central nervous system, cognitive function, memory, learning, insulin receptor, insulin resistance, insulin deficiency, rodent models, neurophysiology
- MeSH terms
- Animals, Central Nervous System, Cognition, Cognition Disorders, Humans, Insulin, Receptor, Insulin, Somatomedins
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