Cited by 270Memory and Neural MechanismsRegulation of Appetite and ObesityNeuroscience and Neuropharmacology Research

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Cognitive effects of insulin in the central nervous system

Park, C.R·2001·Neuroscience & Biobehavioral Reviews

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Abstract

Evidence has been accumulating recently that the hormone insulin may modulate cognitive activity by acting in the central nervous system. Initially derived from the observation that insulin and insulin receptors are found in specific brain areas, this evidence also includes cognitive assessments of humans in insulin-deficient and insulin-resistant disease states and experimental manipulation of rodent models. Additional support is derived from in vivo and in vitro systems that are used to investigate the neurophysiological basis of learning and memory. This article is a brief review of the literature that suggests a connection between insulin and memory and draws together some of the findings relevant to possible physiological mechanisms for this cognitive effect.

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Authors: Park, C. R.
Affiliations: University of South Florida (US)
Corresponding author: Park, C.R
ORCID: Park, C.R
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2001-06
Volume: 25
Issue: 4
Pages: 311-323
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/s0149-7634(01)00016-1
OpenAlex: W2013952491
Cited by: 270
References: 206
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 13 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 12
FWCI: 1.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: insulin, central nervous system, cognitive function, memory, learning, insulin receptor, insulin resistance, insulin deficiency, rodent models, neurophysiology
MeSH terms: Animals, Central Nervous System, Cognition, Cognition Disorders, Humans, Insulin, Receptor, Insulin, Somatomedins

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Cognitive effects of insulin in the central nervous system

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