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Cited by 100Regulation of Appetite and ObesityDiet, Metabolism, and DiseaseBiochemical Analysis and Sensing Techniques

Carbohydrate-induced hyperphagia and obesity in the rat: Effects of saccharide type, form, and taste

Sclafani, Anthony·1987·Neuroscience & Biobehavioral Reviews
DOI 10.1016/s0149-7634(87)80020-9
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Abstract

Adult female rats were fed, in addition to chow and water, a carbohydrate source that differed in type (glucose, sucrose, or polysaccharide), form (32% solution, powder, or gel), or taste (very sweet, minimally sweet, or bitter). A control group was fed only chow and water during the 40-day experiment. The groups fed the glucose solution, sucrose solution, or one of three polysaccharide solutions (Polycose, maltose-dextrin 10, maltose-dextrin 42) all overrate and gained more body weight and fat than did the control group. The carbohydrate solution groups did not differ in their total caloric intake, weight gain, percent body fat, or basal insulin level. The polysaccharide groups, however, consumed more carbohydrate than did the sugar groups. The groups fed glucose, sucrose, or Polycose in powder form consumed less carbohydrate and total calories, gained less weight and fat, and had lower insulin levels than did the groups fed the saccharides in solution form. The powder groups did not reliably differ from the control group on these measures. Rats fed Polycose in solution form or in a solid gel form (32% Polycose + 1% agar) were similar in their carbohydrate intake, total caloric intake, weight gain, and percent body fat. Rats fed Polycose solutions that were minimally sweet (32% Polycose), sweet (0.2% saccharin + 32% Polycose), or bitter [0.05% sucrose octa acetate (SOA) + 32% Polycose] did not differ in their Polycose intake, total caloric intake, weight gain, or percent body fat. The results demonstrate that saccharide form is more important than saccharide type or taste in promoting hyperphagia and obesity in rats. The Polycose gel findings further indicate that it is the water of hydration, not liquidity that is responsible for the hyperphagia-inducing effect of carbohydrate solutions.

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  • Unlimited access to palatable food leads to hedonic overeating and eventually obesity (the gluttony hypothesis).

    “One fundamental premise here is that unlimited access to palatable food leads to hedonic overeating and eventually obesity, called the gluttony hypothesis for simplicity.”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [151]

  • Numerous animal studies demonstrate increased intake of palatable foods and development of diet-induced obesity.

    “This hypothesis is supported by numerous studies in animals demonstrating increased intake of palatable foods and development of obesity, so called diet-induced obesity”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [151]

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Authors
Sclafani, A.
Affiliations
City University of New York (US)
Corresponding author
Sclafani, Anthony
ORCID
Sclafani, Anthony
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1987
Volume
11
Issue
2
Pages
155-162
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/s0149-7634(87)80020-9
OpenAlex
W2001446466
Cited by
100
References
43
Citations by year
2026: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
6.40
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (DK-31135, AM-26687)
  • City University of New York
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
obesity, glucose, sucrose, polysaccharides, Polycose, weight gain, fat mass, insulin, energy intake, hydration water, bitter taste, rats
MeSH terms
Animals, Feeding and Eating Disorders, Blood Glucose, Body Weight, Energy Intake, Dietary Carbohydrates, Female, Glucans, Hyperphagia, Insulin, Obesity, Polysaccharides, Rats, Inbred Strains, Sucrose, Taste, Rats

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