The DOI matches its Crossref record.
The Effect of Age on Normal Human Optic Nerve Fiver Number and Diameter
Open accessAbstract
In one optic nerve from each of 19 persons, the authors determined the number of axons, the distribution of fiber diameter, and the total neural area. The mean fiber count was 693,316, the mean neural area was 5.17 mm2, and the mean axonal fiber diameter was 0.96 microns. No significant decline in fiber number or neural area with increasing age was found. The authors found a large variability of axonal number among their patients. This variability would have obscured any small effect of aging. Linear regression analysis of the effect of age on mean axonal diameter yielded a slight negative slope (P less than 0.01), suggesting a redistribution of fiber diameter. This could occur from axonal shrinkage, from preferential large fiber loss, or from the technical features of tissue acquisition and analysis. The authors suspect that the explanation is a selective loss of large nerve fibers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography
Leung, C. K.-S., Cheung, C. Y.-L., Weinreb, R. N., Qiu, Q., Liu, S., Li, H., Xu, G., Fan, N., Huang, L., Pang, C.-P., et al. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.04.013 · Cited by 486
TUNEL-Positive Ganglion Cells in Human Primary Open-angle Glaucoma
Kerrigan, L. A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100160201010 · Cited by 465
Neural bases of visual deficits during aging
Spear, P. D. (1993) · Vision Research · doi:10.1016/0042-6989(93)90218-l · Cited by 406
Correlated Size Variations in Human Visual Cortex, Lateral Geniculate Nucleus, and Optic Tract
Andrews, T. J., Halpern, S. D., & Purves, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02859.1997 · Cited by 377
Race-, Age-, Gender-, and Refractive Error—Related Differences in the Normal Optic Disc
Varma, R. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090200074026 · Cited by 373
Metadata
- Authors
- Repka, M. X., & Quigley, H. A.
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 96
- Issue
- 1
- Pages
- 26-32
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W2125948382
- Cited by
- 296
- References
- 0
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Effect of Age on Normal Human Optic Nerve Fiver Number and Diameter. https://app.cochat.ai/papers/10.1016/s0161-6420(89)32928-9
- The paper
- Repka, M. X., & Quigley, H. A. (1989). The Effect of Age on Normal Human Optic Nerve Fiver Number and Diameter. Ophthalmology. https://doi.org/10.1016/s0161-6420(89)32928-9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
