The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Monoamine Oxidase and Cigarette Smoking
Abstract
Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence that this is a pharmacological effect of tobacco smoke exposure rather than a biological characteristic of smokers. This article summarizes human and animal studies documenting the inhibitory effects of tobacco smoke on MAO and discusses MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, cigarette smoke reduces Monoamine oxidase (MAO) A and B activity (27), prolonging the synaptic action of neurotransmitters with a role in mood regulation (e.g., serotonin and dopamine).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [27]
Citations
Cites
Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914
THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,568
Some observations upon a new inhibitor of monoamine oxidase in brain tissue
Johnston, J. P. (1968) · Biochemical Pharmacology · doi:10.1016/0006-2952(68)90066-x · Cited by 1,597
MONOAMINE OXIDASE: From Genes to Behavior
Shih, J. C., Chen, K., & Ridd, M. J. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.197 · Cited by 1,235
Smoking, smoking cessation, and major depression
Glassman, A. H. (1990) · JAMA · doi:10.1001/jama.1990.03450120058029 · Cited by 1,207
Prevalence of smoking among psychiatric outpatients
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.8.993 · Cited by 1,058
Heikkila, R. E., Manzino, L., Cabbat, F. S., & Duvoisin, R. C. (1984) · Nature · doi:10.1038/311467a0 · Cited by 1,010
Pharmacologic Aspects of Cigarette Smoking and Nicotine Addiction
Oates, J. A., Wood, A. J. J., & Benowitz, N. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198811173192005 · Cited by 969
Bach, A. W., Lan, N. C., Johnson, D. L., Abell, C. W., Bembenek, M. E., Kwan, S. W., SEEBURG, P. H., & Shih, J. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4934 · Cited by 725
Inhibition of monoamine oxidase B in the brains of smokers
Fowler, J. S., Volkow, N. D., Wang, G., Pappas, N. R., Logan, J., MacGregor, R. R., Alexoff, D. L., Shea, C. E., Schlyer, D. J., Wolf, A. P., et al. (1996) · Nature · doi:10.1038/379733a0 · Cited by 657
Self-citationThe Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease
Tetrud, J. W., & Langston, J. W. (1989) · Science · doi:10.1126/science.2502843 · Cited by 635
Pargyline Prevents MPTP-Induced Parkinsonism in Primates
Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S. (1984) · Science · doi:10.1126/science.6332378 · Cited by 581
Some puzzling pharmacological effects of monoamine oxidase inhibitors.
Knoll, J. E., & Magyar, K. (1972) · PubMed · Cited by 560
Brain monoamine oxidase A inhibition in cigarette smokers
Fowler, J. S., Volkow, N. D., Wang, G., Pappas, N. R., Logan, J., Shea, C. E., Alexoff, D. L., MacGregor, R. R., Schlyer, D. J., Zezulkova, I., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14065 · Cited by 424
Self-citationMapping Human Brain Monoamine Oxidase A and B with11C-Labeled Suicide Inactivators and PET
Fowler, J. S., MacGregor, R. R., Wolf, A. P., Arnett, C. D., Dewey, S. L., Schlyer, D. J., Christman, D. R., Logan, J., Smith, M. R., Sachs, H., et al. (1987) · Science · doi:10.1126/science.3099392 · Cited by 389
Self-citationBuchsbaum, M. S., Coursey, R. D., & Murphy, D. L. (1976) · Science · doi:10.1126/science.968488 · Cited by 377
Smoking cessation and the course of major depression: A follow-up study
Glassman, A. H., Covey, L. S., Stetner, F., & Rivelli, S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05064-9 · Cited by 370
Cigarette smoking and protection from Parkinson's disease
Morens, D. M., Grandinetti, A., REED, D. M., White, L. R., & Ross, G. W. (1995) · Neurology · doi:10.1212/wnl.45.6.1041 · Cited by 368
Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow
Cohen, G., Farooqui, R., & Kesler, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.4890 · Cited by 286
Hare, M. L. C. (1928) · Biochemical Journal · doi:10.1042/bj0220968 · Cited by 283
Smoking, smoking cessation, and major depression
Glassman, A. H. (1990) · JAMA · doi:10.1001/jama.264.12.1546 · Cited by 251
Involvement of tobacco in alcoholism and illicit drug use
Henningfield, J. E., Clayton, R., & Pollin, W. (1990) · British Journal of Addiction · doi:10.1111/j.1360-0443.1990.tb03084.x · Cited by 240
Differences in Platelet Enzyme Activity between Alcoholics and Nonalcoholics
Tabakoff, B., Hoffman, P. L., Lee, J. M., Saito, T., Willard, B., & DeLeon-Jones, F. A. (1988) · New England Journal of Medicine · doi:10.1056/nejm198801213180302 · Cited by 240
Ryan, R. E., Ross, S. A., Drago, J., & Loiacono, R. E. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703989 · Cited by 188
Zeller, E. A., Barsky, J., & Berman, E. R. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70965-4 · Cited by 184
Über den enzymatischen Abbau von Histamin und Diaminen. 2. Mitteilung
Zeller, E. A. (1938) · Helvetica Chimica Acta · doi:10.1002/hlca.193802101115 · Cited by 170
High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers
Salokangas, R. K. R., Vilkman, H., Ilonen, T., Taiminen, T., Bergman, J., Haaparanta, M., Solin, O., Alanen, A., Syvã«¡hti, E., & Hietala, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.632 · Cited by 164 · cited 2×
“Supporting this is a recent report that comparing presynaptic DA activity in non-smokers and in smokers using PET and [18F]fluoroDOPA (Salokangas et al., 2000).”
ResultFowler, J. S., Wang, G., Logan, J., Xie, S., Volkow, N. D., MacGregor, R. R., Schlyer, D. J., Pappas, N. R., Alexoff, D. L., & Patlak, C. S. (1995) · PubMed · Cited by 163
Self-citationBerlin, I., Saïd, S., Spreux‐Varoquaux, O., Launay, J., Olivares, R., Millet, V., Lecrubier, Y., & Puech, A. J. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90058-6 · Cited by 157
The inactivation of adrenaline
Blaschko, H. K. F., Richter, D., & Schloßmann, H. (1937) · The Journal of Physiology · doi:10.1113/jphysiol.1937.sp003497 · Cited by 151
Monoamine oxidases and tobacco smoking
Berlin, I., & Anthenelli, R. M. (2001) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002188 · Cited by 149
Slow recovery of human brain MAO B after L‐Deprenyl (Selegeline) withdrawal
Fowler, J. S., Volkow, N. D., Logan, J., Wang, G., Gregor, R. R. M., Schlyer, D. J., Wolf, A. P., Pappas, N. R., Alexoff, D. L., Shea, C. E., et al. (1994) · Synapse · doi:10.1002/syn.890180203 · Cited by 147
Self-citationMonoamine oxidase A and B activities in heavy smokers
Berlin, I., Saïd, S., Spreux‐Varoquaux, O., Olivares, R., Launay, J., & Puech, A. J. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00084-4 · Cited by 131
Low platelet monoamine oxidase activity in cigarette smokers
Oreland, L., Fowler, C. J., & Schalling, D. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90706-2 · Cited by 128
TREATMENT OF PULMONARY TUBERCULOSIS WITH HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID
Selikoff, I. J. (1952) · JAMA · doi:10.1001/jama.1952.03680100015006 · Cited by 124
Coursey, R. D., Buchsbaum, M. S., & Murphy, D. L. (1979) · The British Journal of Psychiatry · doi:10.1192/bjp.134.4.372 · Cited by 123
Irreversible inhibition of monoamine oxidase by some components of cigarette smoke
Yu, P. H., & Boulton, A. A. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90446-2 · Cited by 122
Low platelet monoamine oxidase activity in human alcoholics.
Wiberg, Å., Gottfries, C. G., & Oreland, L. (1977) · PubMed · Cited by 111
Bench, C. J., Price, G. W., Lammertsma, A. A., Cremer, J., Luthra, S. K., Turton, D. R., Dolan, R. J., Kettler, R., Dingemanse, J., Prada, M. D., et al. (1991) · European Journal of Clinical Pharmacology · doi:10.1007/bf00280072 · Cited by 105
THE PSYCHIATRIC SIDE-EFFECTS OF IPRONIAZID
Crane, G. E. (1956) · American Journal of Psychiatry · doi:10.1176/ajp.112.7.494 · Cited by 99
Isolation and Characterization of a Monoamine Oxidase Inhibitor from Tobacco Leaves
Khalil, A. A., Steyn, S., & Castagnoli, N. (1999) · Chemical Research in Toxicology · doi:10.1021/tx990146f · Cited by 98
Smoking and Parkinson's disease: a case-control study in Germany
Hellenbrand, W., Seidler, A., Robra, B., Vieregge, P., Oertel, W. H., Joerg, J., NISCHAN, P., Schneider, E., & Ulm, G. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.2.328 · Cited by 87
Anthenelli, R. M., TIPP, J. E., Li, T., Magnes, L., Schuckit, M. A., Rice, J. P., Daw, W., & Nürnberger, J. I. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb04298.x · Cited by 81
Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms
Behm, F. M., Rose, J. E., Ramsey, C., & Ritchie, J. C. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110087277 · Cited by 72
Clinical Pharmacology of Monoamine Oxidase Inhibitors
McDaniel, K. D. (1986) · Clinical Neuropharmacology · doi:10.1097/00002826-198606000-00001 · Cited by 70
Monoamine oxidases: old friends hold many surprises
Singer, T. P., & Ramsay, R. R. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.8.7768351 · Cited by 69
Platelet monoamine oxidase: Low activity in cigarette smokers
Norman, T. R., Chamberlain, K. G., & French, M. A. (1987) · Psychiatry Research · doi:10.1016/0165-1781(87)90079-5 · Cited by 69
Maintenance of Brain Monoamine Oxidase B Inhibition in Smokers After Overnight Cigarette Abstinence
Fowler, J. S., Wang, G., Volkow, N. D., Franceschi, D., Logan, J., Pappas, N. R., Shea, C. E., MacGregor, R. R., & Garza, V. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1864 · Cited by 68
Self-citationDopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase
Vindis, C., Séguélas, M., Lanier, S. M., Parini, A., & Cambon, C. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00468.x · Cited by 67
Personality traits and platelet monoamine oxidase in tobacco smokers
von Knorring, L., & Oreland, L. (1985) · Psychological Medicine · doi:10.1017/s0033291700023606 · Cited by 67
Association of monoamine oxidase (MAO) activity with alcoholism and alcoholic subtypes
Devor, E. J., Cloninger, C. R., Hoffman, P. L., & Tabakoff, B. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320480407 · Cited by 66
Pharmacogenetics and Ethnoracial Differences in Smoking
Sellers, E. M. (1998) · JAMA · doi:10.1001/jama.280.2.179 · Cited by 63
Platelet monoamine oxidase activity and cigarette smoking
Norman, T. R., Chamberlain, K. G., French, M. A., & Burrows, G. D. (1982) · Journal of Affective Disorders · doi:10.1016/0165-0327(82)90021-0 · Cited by 61
Monoamine oxidase B, smoking, and Parkinson's disease
Yong, V. W., & Perry, T. L. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90014-6 · Cited by 59
MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD
Hernán, M. Á., Checkoway, H., O’Brien, R., Costa‐Mallen, P., Vivo, I. D., Colditz, G. A., Hunter, D. J., Kelsey, K. T., & Ascherio, A. (2002) · Neurology · doi:10.1212/wnl.58.9.1381 · Cited by 59
Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by tobacco smoke
Carr, L. A., & Rowell, P. P. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90019-n · Cited by 58
Neuroprotection in the MPTP Parkinsonian C57BL/6 Mouse Model by a Compound Isolated from Tobacco
Castagnoli, K., Steyn, S. J., Petzer, J. P., der Schyf, C. J. V., & Castagnoli, N. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000224v · Cited by 57
Hauptmann, N., & Shih, J. C. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)01022-5 · Cited by 52
Youdim, M. B. H., & Riederer, P. F. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245231 · Cited by 52
Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non-smokers
Fowler, J. S., Wang, G., Volkow, N. D., Franceschi, D., Logan, J., Pappas, N. R., Shea, C. E., MacGregor, R. R., & Garza, V. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050011451 · Cited by 49
Self-citationCarr, L. A., & Basham, J. K. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90455-k · Cited by 49
Shahi, G. S., Das, N. P., & Moochhala, S. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90804-3 · Cited by 47
An acute dose of nicotine does not inhibit MAO B in baboon brain in vivo
Fowler, J. S., Volkow, N. D., Logan, J., Pappas, N. R., King, P. T., MacGregor, R. R., Shea, C. E., Garza, V., & Gatley, S. J. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00251-3 · Cited by 41
Self-citationPlatelet MAO activity in subtypes of alcoholics and controls in a homogenous population
Farren, C. K., Clare, A. W., Tipton, K. F., & Dinan, T. G. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00047-8 · Cited by 36
Berlin, I., Spreux‐Varoquaux, O., Saïd, S., & Launay, J. (1997) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(97)01338-0 · Cited by 33
Low platelet monoamine oxidase activity in Swedish imprisoned criminal offenders
Garpenstrand, H. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00148-1 · Cited by 33
Schizophrenia, Monoamine Oxidase Activity, and Cigarette Smoking
Simpson, G. M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00119-5 · Cited by 32
Soto‐Otero, R., Méndez‐Álvarez, E., Riguera, R., Quiñoá, E., Sánchez‐Sellero, I., & López‐Rivadulla, M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00538-1 · Cited by 29
Oreland, L., Garpenstrand, H., Damberg, M., Alm, P. O., Thorell, L. H., af Klinteberg, B., & Ekblom, J. (1999) · PubMed · Cited by 25
Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology
Richards, J. G., Saura, J., Luque, J. M., Cesura, A. M., Gottowik, J., Malherbe, P., Borroni, E., & Gray, J. A. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6499-0_17 · Cited by 25
Platelet monoamine oxidase B activity is inversely associated with plasma cotinine concentration
Berlin, I. (2000) · Nicotine & Tobacco Research · doi:10.1080/14622200050147501 · Cited by 24
Serotonin and monoamine oxidase in mouse skin: effects of cigarette smoke exposure.
Essman, W. B. (1977) · PubMed · Cited by 22
Garpenstrand, H., Longato-Stadler, E., af Klinteberg, B., Grigorenko, E. L., Damberg, M., Oreland, L., & Hallman, J. (2002) · European Neuropsychopharmacology · Cited by 6
Endoprótesis metálicas en territorio ilíaco: seguimiento a largo plazo
Pérez, R. R., Villamor, J. M. C., Moreno, M. D. P., Anllo, M. H., & Moliner, M. M. (1996) · The American Journal of Human Genetics · Cited by 3
Research works printed but not linked: 3
- Brauer LH, Paxton DA, Rose JE. Selegiline and transdermal nicotine for smoking cessation. In: Proceedings of the Sixth Annual Meeting of the Society for Research on Nicotine and Tobacco, Feb 18–20, Arlington, VA. 2000.
- Jossan, 1987, Is monoamine oxidase B activity rate limiting for MPTP neurotoxicity?, Biogenic. Amines, 4, 371
- Pavlin R, Sket D. Effect of cigarette smoke on brain monoamine oxidase activity, Farmacevtski Vestnik 1993;44:185–92.
Cited by
Sorted by citations
Benowitz, N. L. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0809890 · Cited by 1,508
Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988
Self-citationDrug addiction: the neurobiology of behaviour gone awry
Volkow, N. D., & Li, T. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1539 · Cited by 638
Self-citationSensation Seeking And Risky Behavior
Zuckerman, M. (2006) · Choice Reviews Online · doi:10.5860/choice.45-2321 · Cited by 817
Estimating the Harms of Nicotine-Containing Products Using the MCDA Approach
Nutt, D., Phillips, L. D., Balfour, D. J. K., Curran, H. V., Dockrell, M. J., Foulds, J., Fagerström, K. O., Letlape, K., Milton, A., Polosa, R., et al. (2014) · European Addiction Research · doi:10.1159/000360220 · Cited by 439
Metadata
- Authors
- Fowler, J. S., Logan, J., Wang, G.-J., & Volkow, N. D.
- Affiliations
- Brookhaven National Laboratory (US)
- Corresponding author
- Fowler, Joanna S.
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 24
- Issue
- 1
- Pages
- 75-82
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W2138349568
- Cited by
- 251
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 29 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 8
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- National Institute on Drug Abuse
- Brookhaven National Laboratory
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- monoamine oxidase, cigarette smoking, tobacco smoke, monoamine oxidase inhibition, tobacco smoke constituents, smoking cessation, mental illness
- MeSH terms
- Animals, Mental Disorders, Brain, Humans, Monoamine Oxidase, Monoamine Oxidase Inhibitors, Smoking, Smoking Cessation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review