The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Positive and negative regulatory mechanisms that mediate long-term memory storage
Open accessAbstract
The protein kinase A pathway and the cyclic AMP-response element binding protein (CREB) appear to play a critical role in the consolidation of short-term changes in neuronal activity into long-term memory storage in a variety of systems ranging from the gill and siphon withdrawal reflex in Aplysia to olfactory conditioning in Drosophila to spatial and contextual learning in mice. In this review we describe the molecular machinery that mediates memory consolidation in each of these systems. One of the surprising findings to emerge, particularly from studies of long-term facilitation in Aplysia, is that memory storage is mediated by not only positive but also negative regulatory mechanisms, in much the same way as cell division is controlled by the proteins encoded by oncogenes and tumor suppressor genes. This suggests the interesting possibility that there are memory suppressor genes whose protein products impede memory storage.
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Self-citationNMDA receptors, place cells and hippocampal spatial memory
Nakazawa, K., McHugh, T. J., Wilson, M. A., & Tonegawa, S. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1385 · Cited by 619
The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice
Zhang, P., McGrath, B. C., Reinert, J., Olsen, D. S., Lei, L., Gill, S., Wek, S. A., Vattem, K. M., Wek, R. C., Kimball, S. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6681-6688.2002 · Cited by 438
Metadata
- Authors
- Abel, T., & Kandel, E.
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 26
- Issue
- 2-3
- Pages
- 360-378
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W1519363809
- Cited by
- 267
- References
- 14
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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