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Cited by 116Obsessive-Compulsive Spectrum DisordersSchizophrenia research and treatmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Neuropsychological performance in medicated vs. unmedicated patients with obsessive–compulsive disorder

Mataix-Cols, David, Alonso, Pino, Pifarré, Josep, Menchón, Josep Manuel, Vallejo, Julio·2002·Psychiatry Research
DOI 10.1016/s0165-1781(02)00024-0
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Abstract

To date, there have been no formal investigations of neuropsychological performance in patients with obsessive-compulsive disorder (OCD) taking psychotropic medications. The purpose of this study was to determine whether medicated and unmedicated patients with OCD demonstrate differences in neuropsychological functioning. Fifty-two patients with a primary DSM-IV diagnosis of OCD participated in the study; 28 were taking serotonin reuptake inhibitors (SRIs), and 24 were treatment-naïve (n=8) or had finished a washout period prior to their inclusion in other studies (n=16). The groups were well matched with regard to demographic and clinical variables, including symptom severity. Each group was administered a comprehensive neuropsychological battery to assess general intelligence, attention, verbal and non-verbal working memory, declarative and procedural learning, visuo-constructive skills, and executive functions. SRI-medicated did not differ from SRI-free patients on any neuropsychological measure. Benzodiazepines seemed to improve the patients' functioning on a semantic verbal fluency test. In addition, there were significant interactions between SRIs and benzodiazepines on the perseverative errors of the Wisconsin Card Sorting Test and on reaction times. SRI-medicated patients with OCD are able to perform on cognitive functioning tests at a comparable level with that of SRI-free patients, and these results have positive implications for OCD patients who respond to SRIs. The interactions between SRIs and benzodiazepines and their effect on cognition in OCD are likely to be complex and deserve further study.

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Crossref · 10.1016/s0165-1781(02)00024-0

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Metadata

Authors
Mataix-Cols, D., Alonso, P., Pifarré, J., Menchón, J. M., & Vallejo, J.
Affiliations
  • Bellvitge University Hospital (ES)
  • Hospital Universitari de Santa Maria (ES)
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2002-04
Volume
109
Issue
3
Pages
255-264
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/s0165-1781(02)00024-0
OpenAlex
W1979451759
Cited by
116
References
37
Citations by year
2026: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 4
FWCI
6.19
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
American Psychological Association
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
obsessive-compulsive disorder, neuropsychological performance, serotonin reuptake inhibitors, benzodiazepines, working memory, executive function, verbal fluency, Wisconsin Card Sorting Test, reaction time, treatment-naive patients
MeSH terms
Adult, Benzodiazepines, Drug Therapy, Combination, Female, Humans, Male, Neuropsychological Tests, Obsessive-Compulsive Disorder, Antipsychotic Agents, Anti-Anxiety Agents, Selective Serotonin Reuptake Inhibitors

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